The Hippo pathway effector Wwtr1 regulates cardiac wall maturation in zebrafish

Cardiac trabeculation is a highly regulated process that starts with the delamination of compact layer cardiomyocytes. The Hippo signaling pathway has been implicated in cardiac development but many questions remain. We have investigated the role of Wwtr1, a nuclear effector of the Hippo pathway, in...

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Veröffentlicht in:	Development (Cambridge) 2018-05, Vol.145 (10), p.dev159210-dev159210
Hauptverfasser:	Lai, Jason K H, Collins, Michelle M, Uribe, Veronica, Jiménez-Amilburu, Vanesa, Günther, Stefan, Maischein, Hans-Martin, Stainier, Didier Y R
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actomyosin Animals Animals, Genetically Modified Cardiomyocytes Cell junctions Cell Proliferation - physiology Cortex Danio rerio ErbB-2 protein Heart Heart - embryology Heart - growth & development Heart diseases Intercellular Junctions - physiology Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Investigations Localization Maturation Morpholinos - genetics Myocytes, Cardiac - cytology Myosin Heavy Chains - genetics Neuregulins - metabolism Nuclear transport Organogenesis - genetics Organogenesis - physiology Protein-Serine-Threonine Kinases - metabolism Receptor, ErbB-2 - metabolism Signal transduction Signal Transduction - physiology Trans-Activators - metabolism Troponin T - genetics Zebrafish Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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