Proteoglycan 4 regulates macrophage function without altering atherosclerotic lesion formation in a murine bone marrow-specific deletion model

Proteoglycan 4 (Prg4) has a high structural similarity with the established atherosclerosis-modulating proteoglycan versican, but its role in atherogenesis is still unknown. Therefore, the impact of Prg4 deficiency on macrophage function in vitro and atherosclerosis susceptibility in vivo was invest...

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Veröffentlicht in:	Atherosclerosis 2018-07, Vol.274, p.120-127
Hauptverfasser:	Nahon, Joya E., Hoekstra, Menno, Havik, Stefan R., Van Santbrink, Peter J., Dallinga-Thie, Geesje M., Kuivenhoven, Jan-Albert, Geerling, Janine J., Van Eck, Miranda
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atherosclerosis Atherosclerosis - genetics Atherosclerosis - metabolism Atherosclerosis - pathology ATP Binding Cassette Transporter 1 - metabolism Bone Marrow Cells - metabolism Bone Marrow Cells - pathology Bone Marrow Transplantation Carotid Arteries - metabolism Carotid Arteries - pathology Carotid Artery Diseases - genetics Carotid Artery Diseases - metabolism Carotid Artery Diseases - pathology Cells, Cultured Cholesterol - metabolism Disease Models, Animal Foam Cells - drug effects Foam Cells - metabolism Foam Cells - pathology Foam Cells - transplantation Humans Inflammation Mediators - metabolism Lipopolysaccharides - pharmacology Macrophage function Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Macrophages, Peritoneal - pathology Macrophages, Peritoneal - transplantation Male Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout, ApoE Phenotype Plaque, Atherosclerotic Proteoglycan 4 Proteoglycans Proteoglycans - deficiency Proteoglycans - genetics Proteoglycans - metabolism Scavenger Receptors, Class B - metabolism Tumor Necrosis Factor-alpha - metabolism
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