Modeling Gadoxetate Liver Uptake and Efflux Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging Enables Preclinical Quantification of Transporter Drug-Drug Interactions

OBJECTIVESThe aim of this study was to model the in vivo transporter-mediated uptake and efflux of the hepatobiliary contrast agent gadoxetate in the liver. The efficacy of the proposed technique was assessed for its ability to provide quantitative insights into drug-drug interactions (DDIs), using...

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Veröffentlicht in:	Investigative radiology 2018-09, Vol.53 (9), p.563-570
Hauptverfasser:	Georgiou, Leonidas, Penny, Jeffrey, Nicholls, Glynis, Woodhouse, Neil, Blé, François-Xavier, Naish, Josephine H, Hubbard Cristinacce, Penny L
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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