GITR domain inside CAR co-stimulates activity of CAR-T cells against cancer

T cells expressing Chimeric antigen receptors or CAR-T cells are used as a novel treatment against hematological and solid cancers. In this report, we designed CAR with glucocorticoid-induced TNFR-related protein (GITR) co-stimulatory domain to study its ability to co-activate CAR-T cells. EGFR-GITR...

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Veröffentlicht in:	Frontiers in bioscience 2018-06, Vol.23 (12), p.2245-2254, Article 4703
Hauptverfasser:	Golubovskaya, Vita M, Berahovich, Robert, Xu, Qumiao, Zhou, Hua, Xu, Shirley, Guan, Jasper, Harto, Hizkia, Li, Le, Wu, Lijun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD19 - genetics Antigens, CD19 - immunology Antigens, CD19 - metabolism CD3 Complex - genetics CD3 Complex - immunology CD3 Complex - metabolism Cell Line, Tumor Cytotoxicity, Immunologic - immunology Glucocorticoid-Induced TNFR-Related Protein - genetics Glucocorticoid-Induced TNFR-Related Protein - immunology Glucocorticoid-Induced TNFR-Related Protein - metabolism HEK293 Cells Humans Male MCF-7 Cells Mesothelin Mice, Inbred NOD Mice, Knockout Mice, SCID Neoplasms - immunology Neoplasms - pathology Receptors, Chimeric Antigen - genetics Receptors, Chimeric Antigen - immunology Receptors, Chimeric Antigen - metabolism T-Lymphocytes - immunology T-Lymphocytes - metabolism Xenograft Model Antitumor Assays - methods
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