Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans

P-glycoprotein (P-gp), encoded by the MDR1 gene in humans and by the Mdr1a/1b genes in rodents, is expressed in numerous tissues and performs as an efflux pump to limit the distribution and absorption of many drugs. Owing to species differences of P-gp between humans and rodents, it is difficult to...

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Veröffentlicht in:	Drug metabolism and disposition 2018-11, Vol.46 (11), p.1756-1766
Hauptverfasser:	Yamasaki, Yuki, Kobayashi, Kaoru, Okuya, Fuka, Kajitani, Naoyo, Kazuki, Kanako, Abe, Satoshi, Takehara, Shoko, Ito, Shingo, Ogata, Seiryo, Uemura, Tatsuki, Ohtsuki, Sumio, Minegishi, Genki, Akita, Hidetaka, Chiba, Kan, Oshimura, Mitsuo, Kazuki, Yasuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tissues Animals Artificial chromosomes ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism Biological Transport - physiology Blood-brain barrier Blood-Brain Barrier - metabolism Brain - metabolism Cell Line Chickens - metabolism Chromosomes - metabolism Drugs Efflux Epithelial cells Female Gene expression Glycoproteins Humans Intestinal Mucosa - metabolism Intestine Male Mathematical models MDR1 protein Mice Mice, Inbred ICR Mice, Knockout mRNA Multidrug resistance P-Glycoprotein Paclitaxel Pharmaceutical Preparations - metabolism Pharmacokinetics Pharmacology Pretreatment Rodentia Rodents Species Substrates Tissue Distribution - physiology
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