A 28-day oral (dietary) toxicity study of sucromalt in Sprague–Dawley rats
A new sweetener, sucromalt, was produced via enzymatic conversion of sucrose and maltose to a mixture of fructose, leucrose and gluco-oligosaccharides. The present study evaluated the safety of this sweetener when administered as a dietary admix at concentrations of 50, 100 and 200 g/kg to Sprague–D...
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| Veröffentlicht in: | Food and chemical toxicology 2007-11, Vol.45 (11), p.2304-2311 |
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| container_title | Food and chemical toxicology |
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| creator | Eapen, Alex K. Chengelis, Christopher P. Jordan, Nancy P. Baumgartner, Roxanne E. Zheng, Guo-Hua Carlson, Ting |
| description | A new sweetener, sucromalt, was produced via enzymatic conversion of sucrose and maltose to a mixture of fructose, leucrose and gluco-oligosaccharides. The present study evaluated the safety of this sweetener when administered as a dietary admix at concentrations of 50, 100 and 200
g/kg to Sprague–Dawley rats for 28 days. There were no treatment-related effects on the general condition and behavior as determined by clinical observations, functional observational battery and locomotor activity assessments. Evaluation of clinical pathology parameters revealed no toxicologically-relevant treatment-related effects on hematology, serum chemistry or urinalysis. Macroscopic and microscopic findings revealed no treatment-related effects on any organ evaluated. A treatment-related increase in mean food consumption was observed resulting in slightly higher body weight gains (2–4%) for both the male and female rats, which was not toxicologically relevant. Results of this study clearly demonstrate that consumption of high concentrations of sucromalt for 28 days is not associated with obvious signs of toxicity. |
| doi_str_mv | 10.1016/j.fct.2007.06.008 |
| format | Article |
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g/kg to Sprague–Dawley rats for 28 days. There were no treatment-related effects on the general condition and behavior as determined by clinical observations, functional observational battery and locomotor activity assessments. Evaluation of clinical pathology parameters revealed no toxicologically-relevant treatment-related effects on hematology, serum chemistry or urinalysis. Macroscopic and microscopic findings revealed no treatment-related effects on any organ evaluated. A treatment-related increase in mean food consumption was observed resulting in slightly higher body weight gains (2–4%) for both the male and female rats, which was not toxicologically relevant. Results of this study clearly demonstrate that consumption of high concentrations of sucromalt for 28 days is not associated with obvious signs of toxicity.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2007.06.008</identifier><identifier>PMID: 17658210</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>animal models ; animal organs ; Animals ; Behavior, Animal - drug effects ; Biological and medical sciences ; Body Weight - drug effects ; Diet ; Dietary ; dietary exposure ; Disaccharides - chemistry ; Disaccharides - toxicity ; Dose-Response Relationship, Drug ; Eye - drug effects ; Female ; Fructose - chemistry ; Fructose - toxicity ; histopathology ; Male ; Medical sciences ; Motor Activity - drug effects ; Oligosaccharides - chemistry ; Oligosaccharides - toxicity ; Rats ; Rats, Sprague-Dawley ; safety testing ; Sprague–Dawley ; Sucromalt ; sweeteners ; Sweetening Agents - chemistry ; Sweetening Agents - toxicity ; Time Factors ; toxicity testing ; Toxicology</subject><ispartof>Food and chemical toxicology, 2007-11, Vol.45 (11), p.2304-2311</ispartof><rights>2007 Elsevier Ltd</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-18b452f0b3bf2b0569f8b125cc413cfb76efcc926f65465d4f6839d9e411ce463</citedby><cites>FETCH-LOGICAL-c351t-18b452f0b3bf2b0569f8b125cc413cfb76efcc926f65465d4f6839d9e411ce463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0278691507001962$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27902,27903,65308</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19163412$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17658210$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eapen, Alex K.</creatorcontrib><creatorcontrib>Chengelis, Christopher P.</creatorcontrib><creatorcontrib>Jordan, Nancy P.</creatorcontrib><creatorcontrib>Baumgartner, Roxanne E.</creatorcontrib><creatorcontrib>Zheng, Guo-Hua</creatorcontrib><creatorcontrib>Carlson, Ting</creatorcontrib><title>A 28-day oral (dietary) toxicity study of sucromalt in Sprague–Dawley rats</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>A new sweetener, sucromalt, was produced via enzymatic conversion of sucrose and maltose to a mixture of fructose, leucrose and gluco-oligosaccharides. The present study evaluated the safety of this sweetener when administered as a dietary admix at concentrations of 50, 100 and 200
g/kg to Sprague–Dawley rats for 28 days. There were no treatment-related effects on the general condition and behavior as determined by clinical observations, functional observational battery and locomotor activity assessments. Evaluation of clinical pathology parameters revealed no toxicologically-relevant treatment-related effects on hematology, serum chemistry or urinalysis. Macroscopic and microscopic findings revealed no treatment-related effects on any organ evaluated. A treatment-related increase in mean food consumption was observed resulting in slightly higher body weight gains (2–4%) for both the male and female rats, which was not toxicologically relevant. Results of this study clearly demonstrate that consumption of high concentrations of sucromalt for 28 days is not associated with obvious signs of toxicity.</description><subject>animal models</subject><subject>animal organs</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Diet</subject><subject>Dietary</subject><subject>dietary exposure</subject><subject>Disaccharides - chemistry</subject><subject>Disaccharides - toxicity</subject><subject>Dose-Response Relationship, Drug</subject><subject>Eye - drug effects</subject><subject>Female</subject><subject>Fructose - chemistry</subject><subject>Fructose - toxicity</subject><subject>histopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Motor Activity - drug effects</subject><subject>Oligosaccharides - chemistry</subject><subject>Oligosaccharides - toxicity</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>safety testing</subject><subject>Sprague–Dawley</subject><subject>Sucromalt</subject><subject>sweeteners</subject><subject>Sweetening Agents - chemistry</subject><subject>Sweetening Agents - toxicity</subject><subject>Time Factors</subject><subject>toxicity testing</subject><subject>Toxicology</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9O3DAQhy1UBAvtA_TS-gJqD0k9duwk4oToH5BW6oFythxnjLzKbra2A91b34E35Enwdlfi1ovn4G9mfvMR8h5YCQzUl0XpbCo5Y3XJVMlYc0Bm0NSiUELCGzJjvG4K1YI8JicxLlgGoVZH5Di_suHAZmR-SXlT9GZDx2AG-qn3mEzYfKZp_OOtTxsa09TnX0fjZMO4NEOifkVv18HcT_j89-mreRxwQ4NJ8S05dGaI-G5fT8nd92-_rq6L-c8fN1eX88LmXKmApqskd6wTneMdk6p1TQdcWluBsK6rFTprW66ckpWSfeVUI9q-xQrAYqXEKTnfzV2H8feEMemljxaHwaxwnKLmrAKpxBaEHZiTxxjQ6XXwy3yfBqa3CvVCZ4V6q1AzpbPC3PNhP3zqlti_duydZeBsD5hozeCCWVkfX7kWlKiAZ-7jjnNm1OY-ZObuljMQ2y1S_It3sSMwy3rwGHS0HlcWex8wx-pH_5-gL2V_lzU</recordid><startdate>200711</startdate><enddate>200711</enddate><creator>Eapen, Alex K.</creator><creator>Chengelis, Christopher P.</creator><creator>Jordan, Nancy P.</creator><creator>Baumgartner, Roxanne E.</creator><creator>Zheng, Guo-Hua</creator><creator>Carlson, Ting</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>200711</creationdate><title>A 28-day oral (dietary) toxicity study of sucromalt in Sprague–Dawley rats</title><author>Eapen, Alex K. ; Chengelis, Christopher P. ; Jordan, Nancy P. ; Baumgartner, Roxanne E. ; Zheng, Guo-Hua ; Carlson, Ting</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-18b452f0b3bf2b0569f8b125cc413cfb76efcc926f65465d4f6839d9e411ce463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>animal models</topic><topic>animal organs</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>Diet</topic><topic>Dietary</topic><topic>dietary exposure</topic><topic>Disaccharides - chemistry</topic><topic>Disaccharides - toxicity</topic><topic>Dose-Response Relationship, Drug</topic><topic>Eye - drug effects</topic><topic>Female</topic><topic>Fructose - chemistry</topic><topic>Fructose - toxicity</topic><topic>histopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Motor Activity - drug effects</topic><topic>Oligosaccharides - chemistry</topic><topic>Oligosaccharides - toxicity</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>safety testing</topic><topic>Sprague–Dawley</topic><topic>Sucromalt</topic><topic>sweeteners</topic><topic>Sweetening Agents - chemistry</topic><topic>Sweetening Agents - toxicity</topic><topic>Time Factors</topic><topic>toxicity testing</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eapen, Alex K.</creatorcontrib><creatorcontrib>Chengelis, Christopher P.</creatorcontrib><creatorcontrib>Jordan, Nancy P.</creatorcontrib><creatorcontrib>Baumgartner, Roxanne E.</creatorcontrib><creatorcontrib>Zheng, Guo-Hua</creatorcontrib><creatorcontrib>Carlson, Ting</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eapen, Alex K.</au><au>Chengelis, Christopher P.</au><au>Jordan, Nancy P.</au><au>Baumgartner, Roxanne E.</au><au>Zheng, Guo-Hua</au><au>Carlson, Ting</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A 28-day oral (dietary) toxicity study of sucromalt in Sprague–Dawley rats</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2007-11</date><risdate>2007</risdate><volume>45</volume><issue>11</issue><spage>2304</spage><epage>2311</epage><pages>2304-2311</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>A new sweetener, sucromalt, was produced via enzymatic conversion of sucrose and maltose to a mixture of fructose, leucrose and gluco-oligosaccharides. The present study evaluated the safety of this sweetener when administered as a dietary admix at concentrations of 50, 100 and 200
g/kg to Sprague–Dawley rats for 28 days. There were no treatment-related effects on the general condition and behavior as determined by clinical observations, functional observational battery and locomotor activity assessments. Evaluation of clinical pathology parameters revealed no toxicologically-relevant treatment-related effects on hematology, serum chemistry or urinalysis. Macroscopic and microscopic findings revealed no treatment-related effects on any organ evaluated. A treatment-related increase in mean food consumption was observed resulting in slightly higher body weight gains (2–4%) for both the male and female rats, which was not toxicologically relevant. Results of this study clearly demonstrate that consumption of high concentrations of sucromalt for 28 days is not associated with obvious signs of toxicity.</abstract><cop>Oxford</cop><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>17658210</pmid><doi>10.1016/j.fct.2007.06.008</doi><tpages>8</tpages></addata></record> |
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| subjects | animal models animal organs Animals Behavior, Animal - drug effects Biological and medical sciences Body Weight - drug effects Diet Dietary dietary exposure Disaccharides - chemistry Disaccharides - toxicity Dose-Response Relationship, Drug Eye - drug effects Female Fructose - chemistry Fructose - toxicity histopathology Male Medical sciences Motor Activity - drug effects Oligosaccharides - chemistry Oligosaccharides - toxicity Rats Rats, Sprague-Dawley safety testing Sprague–Dawley Sucromalt sweeteners Sweetening Agents - chemistry Sweetening Agents - toxicity Time Factors toxicity testing Toxicology |
| title | A 28-day oral (dietary) toxicity study of sucromalt in Sprague–Dawley rats |
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