Flavonoids from the Heartwood of Dalbergia odorifera and Their Protective Effect on Glutamate-Induced Oxidative Injury in HT22 Cells
Two flavonoids, 4,2′,5′-trihydroxy-4′-methoxychalcone (1) and (2S)-6,7,4′-trihydroxyflavan (2), along with fourteen known flavonoids and two other known arylbenzofurans were isolated from the heartwood of Dalbergia odorifera. The structure of compounds 1 and 2 were established by spectroscopic (NMR...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 2008/12/01, Vol.56(12), pp.1722-1724 |
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| container_title | Chemical & pharmaceutical bulletin |
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| creator | An, Ren-Bo Jeong, Gil-Saeng Kim, Youn-Chul |
| description | Two flavonoids, 4,2′,5′-trihydroxy-4′-methoxychalcone (1) and (2S)-6,7,4′-trihydroxyflavan (2), along with fourteen known flavonoids and two other known arylbenzofurans were isolated from the heartwood of Dalbergia odorifera. The structure of compounds 1 and 2 were established by spectroscopic (NMR and MS) analyses. Of the isolates, eight compounds (1, 4, 7, 10, 12, 14, 15, 17) were found to have potent protective effect on glutamate-induced oxidative injury in HT22 cells. |
| doi_str_mv | 10.1248/cpb.56.1722 |
| format | Article |
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The structure of compounds 1 and 2 were established by spectroscopic (NMR and MS) analyses. Of the isolates, eight compounds (1, 4, 7, 10, 12, 14, 15, 17) were found to have potent protective effect on glutamate-induced oxidative injury in HT22 cells.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.56.1722</identifier><identifier>PMID: 19043246</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Animals ; arylbenzofuran ; Cell Line ; Cell Survival - drug effects ; Dalbergia ; Dalbergia - chemistry ; Dalbergia odorifera ; flavonoid ; Flavonoids - pharmacology ; Glutamic Acid - toxicity ; Hippocampus - cytology ; Hippocampus - drug effects ; Leguminosae ; Magnetic Resonance Spectroscopy ; Mice ; Oxidative Stress - drug effects ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Protective Agents - pharmacology ; Spectrometry, Mass, Fast Atom Bombardment ; Spectrophotometry, Ultraviolet ; Wood</subject><ispartof>Chemical and Pharmaceutical Bulletin, 2008/12/01, Vol.56(12), pp.1722-1724</ispartof><rights>2008 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-cfa55c059b10d740ab4f69105ca7904e3f3e4eacf07bca95eeb2631df9402cb53</citedby><cites>FETCH-LOGICAL-c532t-cfa55c059b10d740ab4f69105ca7904e3f3e4eacf07bca95eeb2631df9402cb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19043246$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>An, Ren-Bo</creatorcontrib><creatorcontrib>Jeong, Gil-Saeng</creatorcontrib><creatorcontrib>Kim, Youn-Chul</creatorcontrib><title>Flavonoids from the Heartwood of Dalbergia odorifera and Their Protective Effect on Glutamate-Induced Oxidative Injury in HT22 Cells</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>Two flavonoids, 4,2′,5′-trihydroxy-4′-methoxychalcone (1) and (2S)-6,7,4′-trihydroxyflavan (2), along with fourteen known flavonoids and two other known arylbenzofurans were isolated from the heartwood of Dalbergia odorifera. The structure of compounds 1 and 2 were established by spectroscopic (NMR and MS) analyses. Of the isolates, eight compounds (1, 4, 7, 10, 12, 14, 15, 17) were found to have potent protective effect on glutamate-induced oxidative injury in HT22 cells.</description><subject>Animals</subject><subject>arylbenzofuran</subject><subject>Cell Line</subject><subject>Cell Survival - drug effects</subject><subject>Dalbergia</subject><subject>Dalbergia - chemistry</subject><subject>Dalbergia odorifera</subject><subject>flavonoid</subject><subject>Flavonoids - pharmacology</subject><subject>Glutamic Acid - toxicity</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - drug effects</subject><subject>Leguminosae</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Mice</subject><subject>Oxidative Stress - drug effects</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Protective Agents - pharmacology</subject><subject>Spectrometry, Mass, Fast Atom Bombardment</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Wood</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc9r2zAYQMXYWLNsp92HYLDLcKafdn1cs7YJFLpDdhay9KlRsK1Mkrv13j-8yhJa2EUS6PH4Ph5CHylZUCbOv5l9t5D1gjaMvUIzykVTScb4azQjhLQV4zU_Q-9S2hHCJGn4W3RGWyI4E_UMPV71-j6MwduEXQwDzlvAK9Ax_wnB4uDwD913EO-8xsGG6B1EjfVo8WYLPuKfMWQw2d8DvnSuvHAY8XU_ZT3oDNV6tJMBi2__eqv_UetxN8UH7Ee82jCGl9D36T1643Sf4MPpnqNfV5eb5aq6ub1eL7_fVEZylivjtJSGyLajxDaC6E64uqVEGt2UhYA7DgK0caTpjG4lQMdqTq1rBWGmk3yOvhy9-xh-T5CyGnwyZQI9QpiSYkRQTuvzAn7-D9yFKY5lNkVFTQQjTTHP0dcjZWJIKYJT--gHHR8UJeqQRpU0StbqkKbQn07OqRvAvrCnFgW4OAK7lPUdPAOlhTc9PMvY6TxYXz63OioY-ROkDKHL</recordid><startdate>20081201</startdate><enddate>20081201</enddate><creator>An, Ren-Bo</creator><creator>Jeong, Gil-Saeng</creator><creator>Kim, Youn-Chul</creator><general>The Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20081201</creationdate><title>Flavonoids from the Heartwood of Dalbergia odorifera and Their Protective Effect on Glutamate-Induced Oxidative Injury in HT22 Cells</title><author>An, Ren-Bo ; Jeong, Gil-Saeng ; Kim, Youn-Chul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-cfa55c059b10d740ab4f69105ca7904e3f3e4eacf07bca95eeb2631df9402cb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>arylbenzofuran</topic><topic>Cell Line</topic><topic>Cell Survival - drug effects</topic><topic>Dalbergia</topic><topic>Dalbergia - chemistry</topic><topic>Dalbergia odorifera</topic><topic>flavonoid</topic><topic>Flavonoids - pharmacology</topic><topic>Glutamic Acid - toxicity</topic><topic>Hippocampus - cytology</topic><topic>Hippocampus - drug effects</topic><topic>Leguminosae</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Mice</topic><topic>Oxidative Stress - drug effects</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Protective Agents - pharmacology</topic><topic>Spectrometry, Mass, Fast Atom Bombardment</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>Wood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>An, Ren-Bo</creatorcontrib><creatorcontrib>Jeong, Gil-Saeng</creatorcontrib><creatorcontrib>Kim, Youn-Chul</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>An, Ren-Bo</au><au>Jeong, Gil-Saeng</au><au>Kim, Youn-Chul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Flavonoids from the Heartwood of Dalbergia odorifera and Their Protective Effect on Glutamate-Induced Oxidative Injury in HT22 Cells</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>2008-12-01</date><risdate>2008</risdate><volume>56</volume><issue>12</issue><spage>1722</spage><epage>1724</epage><pages>1722-1724</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><abstract>Two flavonoids, 4,2′,5′-trihydroxy-4′-methoxychalcone (1) and (2S)-6,7,4′-trihydroxyflavan (2), along with fourteen known flavonoids and two other known arylbenzofurans were isolated from the heartwood of Dalbergia odorifera. The structure of compounds 1 and 2 were established by spectroscopic (NMR and MS) analyses. Of the isolates, eight compounds (1, 4, 7, 10, 12, 14, 15, 17) were found to have potent protective effect on glutamate-induced oxidative injury in HT22 cells.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>19043246</pmid><doi>10.1248/cpb.56.1722</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Chemical and Pharmaceutical Bulletin, 2008/12/01, Vol.56(12), pp.1722-1724 |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Animals arylbenzofuran Cell Line Cell Survival - drug effects Dalbergia Dalbergia - chemistry Dalbergia odorifera flavonoid Flavonoids - pharmacology Glutamic Acid - toxicity Hippocampus - cytology Hippocampus - drug effects Leguminosae Magnetic Resonance Spectroscopy Mice Oxidative Stress - drug effects Plant Extracts - chemistry Plant Extracts - pharmacology Protective Agents - pharmacology Spectrometry, Mass, Fast Atom Bombardment Spectrophotometry, Ultraviolet Wood |
| title | Flavonoids from the Heartwood of Dalbergia odorifera and Their Protective Effect on Glutamate-Induced Oxidative Injury in HT22 Cells |
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