Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication

Codeine is an analgesic drug acting on μ -opiate receptors predominantly via its metabolite morphine, which is formed almost exclusively by the genetically polymorphic enzyme cytochrome P450 2D6 (CYP2D6). Whereas it is known that individuals lacking CYP2D6 activity (poor metabolizers, PM) suffer fro...

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Veröffentlicht in:	The pharmacogenomics journal 2007-08, Vol.7 (4), p.257-265
Hauptverfasser:	Kirchheiner, J, Schmidt, H, Tzvetkov, M, Keulen, J-Tha, Lötsch, J, Roots, I, Brockmöller, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Analgesia Analgesics Analgesics, Opioid - administration & dosage Analgesics, Opioid - adverse effects Analgesics, Opioid - pharmacokinetics Area Under Curve Biomedical and Life Sciences Biomedicine Biotransformation Chromosome abnormalities Codeine Codeine - administration & dosage Codeine - adverse effects Codeine - analogs & derivatives Codeine - pharmacokinetics Consciousness - drug effects CYP2D6 protein Cytochrome P-450 CYP2D6 - genetics Cytochrome P-450 CYP2D6 - metabolism Cytochrome P450 Dealkylation Dosage and administration Drug dosages Gene Duplication Gene Expression Gene polymorphism Genotype Genotyping Human Genetics Humans Liquid chromatography Male Mass spectroscopy Metabolites Middle Aged Morphine Morphine - adverse effects Morphine - pharmacokinetics Morphine Derivatives - pharmacokinetics Oncology original-article Pain perception Pharmacokinetics Pharmacotherapy Phenotype Physiological aspects Polymerase chain reaction Psychopharmacology Reference Values Restriction fragment length polymorphism
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