Safety studies of pseudo-ceramide SLE66. Part 2: Metabolism, cytotoxicity and genotoxicity

A synthetic pseudo-ceramide (SLE66) has been shown to improve dryness/itching of human skin. The objective of this study was to investigate metabolism, genotoxicity and cytotoxicity of SLE66. Pharmacokinetic profile of [ 14C]-SLE66 was investigated following oral or transdermal administration to Spr...

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Veröffentlicht in:	Food and chemical toxicology 2009-04, Vol.47 (4), p.674-680
Hauptverfasser:	Morita, Osamu, Ogura, Ryosuke, Hayashi, Kazuhiko, Okuda, Minehiro, Yoshimura, Koichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Administration, Oral Animals Biological and medical sciences Cells, Cultured - drug effects Ceramides - administration & dosage Ceramides - metabolism Ceramides - pharmacokinetics Ceramides - toxicity Chromosome Aberrations Cytotoxicity Feces Genotoxicity Humans Lymphocytes - drug effects Male Medical sciences Metabolism Mutagenicity Tests - methods Pseudo-ceramide Quasi-ceramide Rats, Sprague-Dawley Skin - cytology SLE66 Toxicology
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