Influence of Heat Treatment on Loading of Polymeric Multilayer Microcapsules with Rhodamine B
Layer‐by‐layer assembled polymeric multilayer capsules (PMC) of micrometer sizes are permeable for molecules below 1 KDa; therefore, the efficacy of such capsules in the delivery of low molecular weight water soluble bioactive compounds and drugs is frequently challenged. Thermally induced contracti...
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| Veröffentlicht in: | Macromolecular rapid communications. 2019-03, Vol.40 (5), p.e1800200-n/a |
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| container_title | Macromolecular rapid communications. |
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| creator | Ermakov, Alexey V. Inozemtseva, Olga A. Gorin, Dmitry A. Sukhorukov, Gleb B. Belyakov, Sergei Antipina, Maria N. |
| description | Layer‐by‐layer assembled polymeric multilayer capsules (PMC) of micrometer sizes are permeable for molecules below 1 KDa; therefore, the efficacy of such capsules in the delivery of low molecular weight water soluble bioactive compounds and drugs is frequently challenged. Thermally induced contraction of hollow PMC is explored here to enhance their loading efficacy with model compound, fluorescent rhodamine B (RhB). Four bilayered capsules obtained of poly(diallyldimethylammonium chloride)/polystyrene sulfonate ([PDADMAC/PSS]4) or poly‐l‐arginine/dextran sulfate ([PARG/DS]4) on sacrificial CaCO3 spherical microparticles are postloaded with RhB at ambient or elevated temperatures. The influence of heat on capsule loading is determined quantitatively by varying the amounts of capsules in the batch and keeping the concentration of RhB constant. The applied heat improves the loading efficacy of [PDADMAC/PSS]4 capsules at concentrations up to 2.25 × 109 capsules mL−1, but has a reversed effect on [PARG/DS]4 capsules at all studied concentrations ((0–3.5) × 109 capsules mL−1).
Poly(diallyldimethylammonium chloride)/polystyrene sulfonate [PDADMAC/PSS]4 or poly‐l‐arginine/dextran sulfate [PARG/DS]4 microcapsules are comparatively studied to reveal the effect of elevated temperatures on their postloading with rhodamine B. Heating improves the loading efficacy of [PDADMAC/PSS]4 at concentrations up to 2.25 × 109 capsules mL−1 but is has a reversed effect on [PARG/DS]4 at all studied concentrations ((0–3.5) × 109 capsules mL−1). |
| doi_str_mv | 10.1002/marc.201800200 |
| format | Article |
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Poly(diallyldimethylammonium chloride)/polystyrene sulfonate [PDADMAC/PSS]4 or poly‐l‐arginine/dextran sulfate [PARG/DS]4 microcapsules are comparatively studied to reveal the effect of elevated temperatures on their postloading with rhodamine B. Heating improves the loading efficacy of [PDADMAC/PSS]4 at concentrations up to 2.25 × 109 capsules mL−1 but is has a reversed effect on [PARG/DS]4 at all studied concentrations ((0–3.5) × 109 capsules mL−1).</description><identifier>ISSN: 1022-1336</identifier><identifier>EISSN: 1521-3927</identifier><identifier>DOI: 10.1002/marc.201800200</identifier><identifier>PMID: 29770514</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Arginine ; Bioactive compounds ; Calcium carbonate ; Capsules - chemistry ; Contraction ; Dextran ; Dextran sulfate ; Dextran Sulfate - chemistry ; Drug delivery systems ; Effectiveness ; encapsulation ; Fluorescence ; Heat ; heat exposure ; Heat treatment ; High temperature ; Hot Temperature ; Low molecular weights ; Microcapsules ; Microparticles ; Molecular weight ; Multilayers ; Peptides - chemistry ; Polyethylenes - chemistry ; polymeric multilayer capsules ; Polymers - chemistry ; Polystyrene ; Polystyrene resins ; Polystyrenes - chemistry ; Quaternary Ammonium Compounds - chemistry ; Rhodamine ; rhodamine B ; Rhodamines - chemistry ; vaterite</subject><ispartof>Macromolecular rapid communications., 2019-03, Vol.40 (5), p.e1800200-n/a</ispartof><rights>2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3730-56f711d96f6f265a3549ed7f7a87ef295e2c79933cfdc8e515010474f972df003</citedby><cites>FETCH-LOGICAL-c3730-56f711d96f6f265a3549ed7f7a87ef295e2c79933cfdc8e515010474f972df003</cites><orcidid>0000-0001-8535-5772</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmarc.201800200$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmarc.201800200$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29770514$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ermakov, Alexey V.</creatorcontrib><creatorcontrib>Inozemtseva, Olga A.</creatorcontrib><creatorcontrib>Gorin, Dmitry A.</creatorcontrib><creatorcontrib>Sukhorukov, Gleb B.</creatorcontrib><creatorcontrib>Belyakov, Sergei</creatorcontrib><creatorcontrib>Antipina, Maria N.</creatorcontrib><title>Influence of Heat Treatment on Loading of Polymeric Multilayer Microcapsules with Rhodamine B</title><title>Macromolecular rapid communications.</title><addtitle>Macromol Rapid Commun</addtitle><description>Layer‐by‐layer assembled polymeric multilayer capsules (PMC) of micrometer sizes are permeable for molecules below 1 KDa; therefore, the efficacy of such capsules in the delivery of low molecular weight water soluble bioactive compounds and drugs is frequently challenged. Thermally induced contraction of hollow PMC is explored here to enhance their loading efficacy with model compound, fluorescent rhodamine B (RhB). Four bilayered capsules obtained of poly(diallyldimethylammonium chloride)/polystyrene sulfonate ([PDADMAC/PSS]4) or poly‐l‐arginine/dextran sulfate ([PARG/DS]4) on sacrificial CaCO3 spherical microparticles are postloaded with RhB at ambient or elevated temperatures. The influence of heat on capsule loading is determined quantitatively by varying the amounts of capsules in the batch and keeping the concentration of RhB constant. The applied heat improves the loading efficacy of [PDADMAC/PSS]4 capsules at concentrations up to 2.25 × 109 capsules mL−1, but has a reversed effect on [PARG/DS]4 capsules at all studied concentrations ((0–3.5) × 109 capsules mL−1).
Poly(diallyldimethylammonium chloride)/polystyrene sulfonate [PDADMAC/PSS]4 or poly‐l‐arginine/dextran sulfate [PARG/DS]4 microcapsules are comparatively studied to reveal the effect of elevated temperatures on their postloading with rhodamine B. Heating improves the loading efficacy of [PDADMAC/PSS]4 at concentrations up to 2.25 × 109 capsules mL−1 but is has a reversed effect on [PARG/DS]4 at all studied concentrations ((0–3.5) × 109 capsules mL−1).</description><subject>Arginine</subject><subject>Bioactive compounds</subject><subject>Calcium carbonate</subject><subject>Capsules - chemistry</subject><subject>Contraction</subject><subject>Dextran</subject><subject>Dextran sulfate</subject><subject>Dextran Sulfate - chemistry</subject><subject>Drug delivery systems</subject><subject>Effectiveness</subject><subject>encapsulation</subject><subject>Fluorescence</subject><subject>Heat</subject><subject>heat exposure</subject><subject>Heat treatment</subject><subject>High temperature</subject><subject>Hot Temperature</subject><subject>Low molecular weights</subject><subject>Microcapsules</subject><subject>Microparticles</subject><subject>Molecular weight</subject><subject>Multilayers</subject><subject>Peptides - chemistry</subject><subject>Polyethylenes - chemistry</subject><subject>polymeric multilayer capsules</subject><subject>Polymers - chemistry</subject><subject>Polystyrene</subject><subject>Polystyrene resins</subject><subject>Polystyrenes - chemistry</subject><subject>Quaternary Ammonium Compounds - chemistry</subject><subject>Rhodamine</subject><subject>rhodamine B</subject><subject>Rhodamines - chemistry</subject><subject>vaterite</subject><issn>1022-1336</issn><issn>1521-3927</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVpyVdz7TEIeunFm5FkW9YxWdomsEtLSI9FqPKoUZCtjWQT9t9Hy-YDeullNMM8epEeQj4xWDAAfj6YZBccWFcGgHfkiDWcVUJx-b70wHnFhGgPyXHO9wDQ1cAPyCFXUkLD6iPy-3p0YcbRIo2OXqGZ6G0qdcBxonGkq2h6P_7dLX_GsB0weUvXc5h8MFtMdO1titZs8hww00c_3dGbu9ibwY9ILz-SD86EjKfP5wn59e3r7fKqWv34fr28WFVWSAFV0zrJWK9a1zreNkY0tcJeOmk6iY6rBrmVSglhXW87bFgDDGpZOyV57wDECfmyz92k-DBjnvTgs8UQzIhxzppDDbKtpVAF_fwPeh_nNJbXac46qToFvC3UYk-V3-Wc0OlN8sX1VjPQO_F6J16_ii8Xzp5j5z8D9q_4i-kCqD3w6ANu_xOn1xc3y7fwJ938jfc</recordid><startdate>201903</startdate><enddate>201903</enddate><creator>Ermakov, Alexey V.</creator><creator>Inozemtseva, Olga A.</creator><creator>Gorin, Dmitry A.</creator><creator>Sukhorukov, Gleb B.</creator><creator>Belyakov, Sergei</creator><creator>Antipina, Maria N.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8FD</scope><scope>JG9</scope><scope>JQ2</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8535-5772</orcidid></search><sort><creationdate>201903</creationdate><title>Influence of Heat Treatment on Loading of Polymeric Multilayer Microcapsules with Rhodamine B</title><author>Ermakov, Alexey V. ; Inozemtseva, Olga A. ; Gorin, Dmitry A. ; Sukhorukov, Gleb B. ; Belyakov, Sergei ; Antipina, Maria N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3730-56f711d96f6f265a3549ed7f7a87ef295e2c79933cfdc8e515010474f972df003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Arginine</topic><topic>Bioactive compounds</topic><topic>Calcium carbonate</topic><topic>Capsules - chemistry</topic><topic>Contraction</topic><topic>Dextran</topic><topic>Dextran sulfate</topic><topic>Dextran Sulfate - chemistry</topic><topic>Drug delivery systems</topic><topic>Effectiveness</topic><topic>encapsulation</topic><topic>Fluorescence</topic><topic>Heat</topic><topic>heat exposure</topic><topic>Heat treatment</topic><topic>High temperature</topic><topic>Hot Temperature</topic><topic>Low molecular weights</topic><topic>Microcapsules</topic><topic>Microparticles</topic><topic>Molecular weight</topic><topic>Multilayers</topic><topic>Peptides - chemistry</topic><topic>Polyethylenes - chemistry</topic><topic>polymeric multilayer capsules</topic><topic>Polymers - chemistry</topic><topic>Polystyrene</topic><topic>Polystyrene resins</topic><topic>Polystyrenes - chemistry</topic><topic>Quaternary Ammonium Compounds - chemistry</topic><topic>Rhodamine</topic><topic>rhodamine B</topic><topic>Rhodamines - chemistry</topic><topic>vaterite</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ermakov, Alexey V.</creatorcontrib><creatorcontrib>Inozemtseva, Olga A.</creatorcontrib><creatorcontrib>Gorin, Dmitry A.</creatorcontrib><creatorcontrib>Sukhorukov, Gleb B.</creatorcontrib><creatorcontrib>Belyakov, Sergei</creatorcontrib><creatorcontrib>Antipina, Maria N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Macromolecular rapid communications.</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ermakov, Alexey V.</au><au>Inozemtseva, Olga A.</au><au>Gorin, Dmitry A.</au><au>Sukhorukov, Gleb B.</au><au>Belyakov, Sergei</au><au>Antipina, Maria N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Heat Treatment on Loading of Polymeric Multilayer Microcapsules with Rhodamine B</atitle><jtitle>Macromolecular rapid communications.</jtitle><addtitle>Macromol Rapid Commun</addtitle><date>2019-03</date><risdate>2019</risdate><volume>40</volume><issue>5</issue><spage>e1800200</spage><epage>n/a</epage><pages>e1800200-n/a</pages><issn>1022-1336</issn><eissn>1521-3927</eissn><abstract>Layer‐by‐layer assembled polymeric multilayer capsules (PMC) of micrometer sizes are permeable for molecules below 1 KDa; therefore, the efficacy of such capsules in the delivery of low molecular weight water soluble bioactive compounds and drugs is frequently challenged. Thermally induced contraction of hollow PMC is explored here to enhance their loading efficacy with model compound, fluorescent rhodamine B (RhB). Four bilayered capsules obtained of poly(diallyldimethylammonium chloride)/polystyrene sulfonate ([PDADMAC/PSS]4) or poly‐l‐arginine/dextran sulfate ([PARG/DS]4) on sacrificial CaCO3 spherical microparticles are postloaded with RhB at ambient or elevated temperatures. The influence of heat on capsule loading is determined quantitatively by varying the amounts of capsules in the batch and keeping the concentration of RhB constant. The applied heat improves the loading efficacy of [PDADMAC/PSS]4 capsules at concentrations up to 2.25 × 109 capsules mL−1, but has a reversed effect on [PARG/DS]4 capsules at all studied concentrations ((0–3.5) × 109 capsules mL−1).
Poly(diallyldimethylammonium chloride)/polystyrene sulfonate [PDADMAC/PSS]4 or poly‐l‐arginine/dextran sulfate [PARG/DS]4 microcapsules are comparatively studied to reveal the effect of elevated temperatures on their postloading with rhodamine B. Heating improves the loading efficacy of [PDADMAC/PSS]4 at concentrations up to 2.25 × 109 capsules mL−1 but is has a reversed effect on [PARG/DS]4 at all studied concentrations ((0–3.5) × 109 capsules mL−1).</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29770514</pmid><doi>10.1002/marc.201800200</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-8535-5772</orcidid></addata></record> |
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| source | MEDLINE; Wiley Journals |
| subjects | Arginine Bioactive compounds Calcium carbonate Capsules - chemistry Contraction Dextran Dextran sulfate Dextran Sulfate - chemistry Drug delivery systems Effectiveness encapsulation Fluorescence Heat heat exposure Heat treatment High temperature Hot Temperature Low molecular weights Microcapsules Microparticles Molecular weight Multilayers Peptides - chemistry Polyethylenes - chemistry polymeric multilayer capsules Polymers - chemistry Polystyrene Polystyrene resins Polystyrenes - chemistry Quaternary Ammonium Compounds - chemistry Rhodamine rhodamine B Rhodamines - chemistry vaterite |
| title | Influence of Heat Treatment on Loading of Polymeric Multilayer Microcapsules with Rhodamine B |
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