The effects of acute leucine or leucine–glutamine co-ingestion on recovery from eccentrically biased exercise
This study investigated the effects of leucine or leucine + glutamine supplementation on recovery from eccentric exercise. In a double-blind independent groups design, 23 men were randomly assigned to a leucine (0.087 g/kg; n = 8), leucine + glutamine (0.087 g/kg + glutamine 0.3 g/kg; n = 8) or pl...
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| Veröffentlicht in: | Amino acids 2018-07, Vol.50 (7), p.831-839 |
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| creator | Waldron, Mark Ralph, Cameron Jeffries, Owen Tallent, Jamie Theis, Nicola Patterson, Stephen David |
| description | This study investigated the effects of leucine or leucine + glutamine supplementation on recovery from eccentric exercise. In a double-blind independent groups design, 23 men were randomly assigned to a leucine (0.087 g/kg;
n
= 8), leucine + glutamine (0.087 g/kg + glutamine 0.3 g/kg;
n
= 8) or placebo (0.3 g/kg maltodextrin;
n
= 7) group. Participants performed 5 sets of drop jumps, with each set comprising 20 repetitions. Isometric knee-extensor strength, counter-movement jump (CMJ) height, delayed-onset muscle soreness (DOMS) and creatine kinase (CK) were measured at baseline, 1, 24, 48 h and 72 h post-exercise. There was a time × group interaction for isometric strength, CMJ and CK (
P
|
| doi_str_mv | 10.1007/s00726-018-2565-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2040764514</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2039616532</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-e13aa3941da02e9f23cbce006029f876eff1078c815dd3aa3bdef3e8181e60f93</originalsourceid><addsrcrecordid>eNp1kc9K5TAUxoMoenV8ADcScOOm4zlJmzZLEf-BMBtnHXLTE620jSbtMNfVvMO84TyJuVydgQEh5O_vnHx8H2NHCF8RoD5LeRKqAGwKUamqeN1iCyxlPqHW22wBWuqiLCvcY_spPQGgaFDtsj2h6xqaGhcs3D8SJ-_JTYkHz62bJ-I9za4biYf4sf3z6_dDP092WF-7UHTjA6WpCyPPI5ILPyiuuI9h4OQcjVPsnO37FV92NlHL6SdF1yX6wna87RMdvq8H7PvV5f3FTXH37fr24vyucLIWU0EorZW6xNaCIO2FdEtHAAqE9k2tsmKEunENVm27RpcteUkNNkgKvJYH7HTT9zmGlzlLNUOXHPW9HSnMyQgooVbZmjKjJ_-hT2GOY1aXKakVqkqKTOGGcjGkFMmb59gNNq4MglmnYTZpmJyGWadhXnPN8XvneTlQ-7fiw_4MiA2Q8lN2NP77-vOub4LSl_4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2039616532</pqid></control><display><type>article</type><title>The effects of acute leucine or leucine–glutamine co-ingestion on recovery from eccentrically biased exercise</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Waldron, Mark ; Ralph, Cameron ; Jeffries, Owen ; Tallent, Jamie ; Theis, Nicola ; Patterson, Stephen David</creator><creatorcontrib>Waldron, Mark ; Ralph, Cameron ; Jeffries, Owen ; Tallent, Jamie ; Theis, Nicola ; Patterson, Stephen David</creatorcontrib><description>This study investigated the effects of leucine or leucine + glutamine supplementation on recovery from eccentric exercise. In a double-blind independent groups design, 23 men were randomly assigned to a leucine (0.087 g/kg;
n
= 8), leucine + glutamine (0.087 g/kg + glutamine 0.3 g/kg;
n
= 8) or placebo (0.3 g/kg maltodextrin;
n
= 7) group. Participants performed 5 sets of drop jumps, with each set comprising 20 repetitions. Isometric knee-extensor strength, counter-movement jump (CMJ) height, delayed-onset muscle soreness (DOMS) and creatine kinase (CK) were measured at baseline, 1, 24, 48 h and 72 h post-exercise. There was a time × group interaction for isometric strength, CMJ and CK (
P
< 0.05), with differences between the leucine + glutamine and placebo group at 48 h and 72 h for strength (
P
= 0.013;
d
= 1.43 and
P
< 0.001;
d
= 2.06), CMJ (
P
= 0.008;
d
= 0.87 and
P
= 0.019;
d
= 1.17) and CK at 24 h (
P
= 0.012;
d
= 0.54) and 48 h (
P
= 0.010;
d
= 1.37). The leucine group produced higher strength at 72 h compared to placebo (
P
= 0.007;
d
= 1.65) and lower CK at 24 h (
P
= 0.039;
d
= 0.63) and 48 h (
P
= 0.022;
d
= 1.03). Oral leucine or leucine + glutamine increased the rate of recovery compared to placebo after eccentric exercise. These findings highlight potential benefits of co-ingesting these amino acids to ameliorate recovery.</description><identifier>ISSN: 0939-4451</identifier><identifier>EISSN: 1438-2199</identifier><identifier>DOI: 10.1007/s00726-018-2565-z</identifier><identifier>PMID: 29770871</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Adult ; Amino acids ; Analytical Chemistry ; Biochemical Engineering ; Biochemistry ; Biomedical and Life Sciences ; Creatine ; Creatine kinase ; Creatine Kinase - analysis ; Dietary Supplements ; Eccentricity ; Exercise - physiology ; Glutamine ; Glutamine - pharmacology ; Humans ; Ingestion ; Isometric Contraction - physiology ; Knee ; Leucine ; Leucine - pharmacology ; Life Sciences ; Male ; Maltodextrin ; Muscle contraction ; Muscle Strength - drug effects ; Muscle Strength - physiology ; Muscles ; Myalgia - prevention & control ; Neurobiology ; Original Article ; Proteomics ; Recovery ; Strength ; Young Adult</subject><ispartof>Amino acids, 2018-07, Vol.50 (7), p.831-839</ispartof><rights>Springer-Verlag GmbH Austria, part of Springer Nature 2018</rights><rights>Amino Acids is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-e13aa3941da02e9f23cbce006029f876eff1078c815dd3aa3bdef3e8181e60f93</citedby><cites>FETCH-LOGICAL-c372t-e13aa3941da02e9f23cbce006029f876eff1078c815dd3aa3bdef3e8181e60f93</cites><orcidid>0000-0002-2720-4615</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00726-018-2565-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00726-018-2565-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29770871$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Waldron, Mark</creatorcontrib><creatorcontrib>Ralph, Cameron</creatorcontrib><creatorcontrib>Jeffries, Owen</creatorcontrib><creatorcontrib>Tallent, Jamie</creatorcontrib><creatorcontrib>Theis, Nicola</creatorcontrib><creatorcontrib>Patterson, Stephen David</creatorcontrib><title>The effects of acute leucine or leucine–glutamine co-ingestion on recovery from eccentrically biased exercise</title><title>Amino acids</title><addtitle>Amino Acids</addtitle><addtitle>Amino Acids</addtitle><description>This study investigated the effects of leucine or leucine + glutamine supplementation on recovery from eccentric exercise. In a double-blind independent groups design, 23 men were randomly assigned to a leucine (0.087 g/kg;
n
= 8), leucine + glutamine (0.087 g/kg + glutamine 0.3 g/kg;
n
= 8) or placebo (0.3 g/kg maltodextrin;
n
= 7) group. Participants performed 5 sets of drop jumps, with each set comprising 20 repetitions. Isometric knee-extensor strength, counter-movement jump (CMJ) height, delayed-onset muscle soreness (DOMS) and creatine kinase (CK) were measured at baseline, 1, 24, 48 h and 72 h post-exercise. There was a time × group interaction for isometric strength, CMJ and CK (
P
< 0.05), with differences between the leucine + glutamine and placebo group at 48 h and 72 h for strength (
P
= 0.013;
d
= 1.43 and
P
< 0.001;
d
= 2.06), CMJ (
P
= 0.008;
d
= 0.87 and
P
= 0.019;
d
= 1.17) and CK at 24 h (
P
= 0.012;
d
= 0.54) and 48 h (
P
= 0.010;
d
= 1.37). The leucine group produced higher strength at 72 h compared to placebo (
P
= 0.007;
d
= 1.65) and lower CK at 24 h (
P
= 0.039;
d
= 0.63) and 48 h (
P
= 0.022;
d
= 1.03). Oral leucine or leucine + glutamine increased the rate of recovery compared to placebo after eccentric exercise. These findings highlight potential benefits of co-ingesting these amino acids to ameliorate recovery.</description><subject>Adult</subject><subject>Amino acids</subject><subject>Analytical Chemistry</subject><subject>Biochemical Engineering</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Creatine</subject><subject>Creatine kinase</subject><subject>Creatine Kinase - analysis</subject><subject>Dietary Supplements</subject><subject>Eccentricity</subject><subject>Exercise - physiology</subject><subject>Glutamine</subject><subject>Glutamine - pharmacology</subject><subject>Humans</subject><subject>Ingestion</subject><subject>Isometric Contraction - physiology</subject><subject>Knee</subject><subject>Leucine</subject><subject>Leucine - pharmacology</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Maltodextrin</subject><subject>Muscle contraction</subject><subject>Muscle Strength - drug effects</subject><subject>Muscle Strength - physiology</subject><subject>Muscles</subject><subject>Myalgia - prevention & control</subject><subject>Neurobiology</subject><subject>Original Article</subject><subject>Proteomics</subject><subject>Recovery</subject><subject>Strength</subject><subject>Young Adult</subject><issn>0939-4451</issn><issn>1438-2199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kc9K5TAUxoMoenV8ADcScOOm4zlJmzZLEf-BMBtnHXLTE620jSbtMNfVvMO84TyJuVydgQEh5O_vnHx8H2NHCF8RoD5LeRKqAGwKUamqeN1iCyxlPqHW22wBWuqiLCvcY_spPQGgaFDtsj2h6xqaGhcs3D8SJ-_JTYkHz62bJ-I9za4biYf4sf3z6_dDP092WF-7UHTjA6WpCyPPI5ILPyiuuI9h4OQcjVPsnO37FV92NlHL6SdF1yX6wna87RMdvq8H7PvV5f3FTXH37fr24vyucLIWU0EorZW6xNaCIO2FdEtHAAqE9k2tsmKEunENVm27RpcteUkNNkgKvJYH7HTT9zmGlzlLNUOXHPW9HSnMyQgooVbZmjKjJ_-hT2GOY1aXKakVqkqKTOGGcjGkFMmb59gNNq4MglmnYTZpmJyGWadhXnPN8XvneTlQ-7fiw_4MiA2Q8lN2NP77-vOub4LSl_4</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>Waldron, Mark</creator><creator>Ralph, Cameron</creator><creator>Jeffries, Owen</creator><creator>Tallent, Jamie</creator><creator>Theis, Nicola</creator><creator>Patterson, Stephen David</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2720-4615</orcidid></search><sort><creationdate>20180701</creationdate><title>The effects of acute leucine or leucine–glutamine co-ingestion on recovery from eccentrically biased exercise</title><author>Waldron, Mark ; Ralph, Cameron ; Jeffries, Owen ; Tallent, Jamie ; Theis, Nicola ; Patterson, Stephen David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-e13aa3941da02e9f23cbce006029f876eff1078c815dd3aa3bdef3e8181e60f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Amino acids</topic><topic>Analytical Chemistry</topic><topic>Biochemical Engineering</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Creatine</topic><topic>Creatine kinase</topic><topic>Creatine Kinase - analysis</topic><topic>Dietary Supplements</topic><topic>Eccentricity</topic><topic>Exercise - physiology</topic><topic>Glutamine</topic><topic>Glutamine - pharmacology</topic><topic>Humans</topic><topic>Ingestion</topic><topic>Isometric Contraction - physiology</topic><topic>Knee</topic><topic>Leucine</topic><topic>Leucine - pharmacology</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Maltodextrin</topic><topic>Muscle contraction</topic><topic>Muscle Strength - drug effects</topic><topic>Muscle Strength - physiology</topic><topic>Muscles</topic><topic>Myalgia - prevention & control</topic><topic>Neurobiology</topic><topic>Original Article</topic><topic>Proteomics</topic><topic>Recovery</topic><topic>Strength</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Waldron, Mark</creatorcontrib><creatorcontrib>Ralph, Cameron</creatorcontrib><creatorcontrib>Jeffries, Owen</creatorcontrib><creatorcontrib>Tallent, Jamie</creatorcontrib><creatorcontrib>Theis, Nicola</creatorcontrib><creatorcontrib>Patterson, Stephen David</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Amino acids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Waldron, Mark</au><au>Ralph, Cameron</au><au>Jeffries, Owen</au><au>Tallent, Jamie</au><au>Theis, Nicola</au><au>Patterson, Stephen David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of acute leucine or leucine–glutamine co-ingestion on recovery from eccentrically biased exercise</atitle><jtitle>Amino acids</jtitle><stitle>Amino Acids</stitle><addtitle>Amino Acids</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>50</volume><issue>7</issue><spage>831</spage><epage>839</epage><pages>831-839</pages><issn>0939-4451</issn><eissn>1438-2199</eissn><abstract>This study investigated the effects of leucine or leucine + glutamine supplementation on recovery from eccentric exercise. In a double-blind independent groups design, 23 men were randomly assigned to a leucine (0.087 g/kg;
n
= 8), leucine + glutamine (0.087 g/kg + glutamine 0.3 g/kg;
n
= 8) or placebo (0.3 g/kg maltodextrin;
n
= 7) group. Participants performed 5 sets of drop jumps, with each set comprising 20 repetitions. Isometric knee-extensor strength, counter-movement jump (CMJ) height, delayed-onset muscle soreness (DOMS) and creatine kinase (CK) were measured at baseline, 1, 24, 48 h and 72 h post-exercise. There was a time × group interaction for isometric strength, CMJ and CK (
P
< 0.05), with differences between the leucine + glutamine and placebo group at 48 h and 72 h for strength (
P
= 0.013;
d
= 1.43 and
P
< 0.001;
d
= 2.06), CMJ (
P
= 0.008;
d
= 0.87 and
P
= 0.019;
d
= 1.17) and CK at 24 h (
P
= 0.012;
d
= 0.54) and 48 h (
P
= 0.010;
d
= 1.37). The leucine group produced higher strength at 72 h compared to placebo (
P
= 0.007;
d
= 1.65) and lower CK at 24 h (
P
= 0.039;
d
= 0.63) and 48 h (
P
= 0.022;
d
= 1.03). Oral leucine or leucine + glutamine increased the rate of recovery compared to placebo after eccentric exercise. These findings highlight potential benefits of co-ingesting these amino acids to ameliorate recovery.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>29770871</pmid><doi>10.1007/s00726-018-2565-z</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2720-4615</orcidid></addata></record> |
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| ispartof | Amino acids, 2018-07, Vol.50 (7), p.831-839 |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Amino acids Analytical Chemistry Biochemical Engineering Biochemistry Biomedical and Life Sciences Creatine Creatine kinase Creatine Kinase - analysis Dietary Supplements Eccentricity Exercise - physiology Glutamine Glutamine - pharmacology Humans Ingestion Isometric Contraction - physiology Knee Leucine Leucine - pharmacology Life Sciences Male Maltodextrin Muscle contraction Muscle Strength - drug effects Muscle Strength - physiology Muscles Myalgia - prevention & control Neurobiology Original Article Proteomics Recovery Strength Young Adult |
| title | The effects of acute leucine or leucine–glutamine co-ingestion on recovery from eccentrically biased exercise |
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