RNA Profiles of Circulating Tumor Cells and Extracellular Vesicles for Therapy Stratification of Metastatic Breast Cancer Patients

Liquid biopsies are discussed to provide surrogate markers for therapy stratification and monitoring. We compared messenger RNA (mRNA) profiles of circulating tumor cells (CTCs) and extracellular vesicles (EVs) in patients with metastatic breast cancer (MBC) to estimate their utility in therapy mana...

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Veröffentlicht in:	Clinical chemistry (Baltimore, Md.) Md.), 2018-07, Vol.64 (7), p.1054-1062
Hauptverfasser:	Keup, Corinna, Mach, Pawel, Aktas, Bahriye, Tewes, Mitra, Kolberg, Hans-Christian, Hauch, Siegfried, Sprenger-Haussels, Markus, Kimmig, Rainer, Kasimir-Bauer, Sabine
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Biomarkers Biopsy Breast cancer Cancer Cancer therapies Deoxyribonucleic acid DNA DNA methylation ErbB-2 protein ErbB-3 protein Extracellular vesicles Gene expression Metastases Metastasis Monitoring Patients Poly(ADP-ribose) polymerase Polymerase chain reaction Ribonucleic acid RNA Signal transduction Therapy TOR protein Tumor cells Tumors Vesicles
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