An observational clinical case of Zika virus-associated neurological disease is associated with primary IgG response and enhanced TNF levels
Descriptive clinical data help to reveal factors that may provoke Zika virus (ZIKV) neuropathology. The case of a 24-year-old female with a ZIKV-associated severe acute neurological disorder was studied. The levels of ZIKV in the cerebrospinal fluid (CSF) were 50 times higher than the levels in othe...
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| Veröffentlicht in: | Journal of general virology 2018-07, Vol.99 (7), p.913-916 |
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| container_title | Journal of general virology |
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| creator | Delatorre, Edson Miranda, Milene Tschoeke, Diogo A Carvalho de Sequeira, Patrícia Alves Sampaio, Simone Barbosa-Lima, Giselle Rangel Vieira, Yasmine Leomil, Luciana Bozza, Fernando A Cerbino-Neto, José Bozza, Patricia T Ribeiro Nogueira, Rita Maria Brasil, Patrícia Thompson, Fabiano L de Filippis, Ana M B Souza, Thiago Moreno L |
| description | Descriptive clinical data help to reveal factors that may provoke Zika virus (ZIKV) neuropathology. The case of a 24-year-old female with a ZIKV-associated severe acute neurological disorder was studied. The levels of ZIKV in the cerebrospinal fluid (CSF) were 50 times higher than the levels in other compartments. An acute anti-flavivirus IgG, together with enhanced TNF-alpha levels, may have contributed to ZIKV invasion in the CSF, whereas the unbiased genome sequencing [obtained by next-generation sequencing (NGS)] of the CSF revealed that no virus mutations were associated with the anatomic compartments (CSF, serum, saliva and urine). |
| doi_str_mv | 10.1099/jgv.0.001080 |
| format | Article |
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An acute anti-flavivirus IgG, together with enhanced TNF-alpha levels, may have contributed to ZIKV invasion in the CSF, whereas the unbiased genome sequencing [obtained by next-generation sequencing (NGS)] of the CSF revealed that no virus mutations were associated with the anatomic compartments (CSF, serum, saliva and urine).</description><identifier>ISSN: 0022-1317</identifier><identifier>EISSN: 1465-2099</identifier><identifier>DOI: 10.1099/jgv.0.001080</identifier><identifier>PMID: 29771234</identifier><language>eng</language><publisher>England</publisher><subject>Antibodies, Viral - cerebrospinal fluid ; Female ; Genome, Viral ; Humans ; Immunoglobulin G - cerebrospinal fluid ; Neurogenic Inflammation - complications ; Neurogenic Inflammation - diagnosis ; Neurogenic Inflammation - physiopathology ; Neurogenic Inflammation - virology ; Phylogeny ; Tumor Necrosis Factor-alpha - cerebrospinal fluid ; Whole Genome Sequencing ; Young Adult ; Zika Virus - classification ; Zika Virus - genetics ; Zika Virus - isolation & purification ; Zika Virus - pathogenicity ; Zika Virus Infection - complications ; Zika Virus Infection - diagnosis ; Zika Virus Infection - physiopathology ; Zika Virus Infection - virology</subject><ispartof>Journal of general virology, 2018-07, Vol.99 (7), p.913-916</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c329t-9a1c552951a04e4bb428cbd6bfd4e2dbd10cac016e671770fa84beb65a789d9a3</citedby><cites>FETCH-LOGICAL-c329t-9a1c552951a04e4bb428cbd6bfd4e2dbd10cac016e671770fa84beb65a789d9a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3746,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29771234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Delatorre, Edson</creatorcontrib><creatorcontrib>Miranda, Milene</creatorcontrib><creatorcontrib>Tschoeke, Diogo A</creatorcontrib><creatorcontrib>Carvalho de Sequeira, Patrícia</creatorcontrib><creatorcontrib>Alves Sampaio, Simone</creatorcontrib><creatorcontrib>Barbosa-Lima, Giselle</creatorcontrib><creatorcontrib>Rangel Vieira, Yasmine</creatorcontrib><creatorcontrib>Leomil, Luciana</creatorcontrib><creatorcontrib>Bozza, Fernando A</creatorcontrib><creatorcontrib>Cerbino-Neto, José</creatorcontrib><creatorcontrib>Bozza, Patricia T</creatorcontrib><creatorcontrib>Ribeiro Nogueira, Rita Maria</creatorcontrib><creatorcontrib>Brasil, Patrícia</creatorcontrib><creatorcontrib>Thompson, Fabiano L</creatorcontrib><creatorcontrib>de Filippis, Ana M B</creatorcontrib><creatorcontrib>Souza, Thiago Moreno L</creatorcontrib><title>An observational clinical case of Zika virus-associated neurological disease is associated with primary IgG response and enhanced TNF levels</title><title>Journal of general virology</title><addtitle>J Gen Virol</addtitle><description>Descriptive clinical data help to reveal factors that may provoke Zika virus (ZIKV) neuropathology. The case of a 24-year-old female with a ZIKV-associated severe acute neurological disorder was studied. The levels of ZIKV in the cerebrospinal fluid (CSF) were 50 times higher than the levels in other compartments. 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| source | MEDLINE; Microbiology Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Antibodies, Viral - cerebrospinal fluid Female Genome, Viral Humans Immunoglobulin G - cerebrospinal fluid Neurogenic Inflammation - complications Neurogenic Inflammation - diagnosis Neurogenic Inflammation - physiopathology Neurogenic Inflammation - virology Phylogeny Tumor Necrosis Factor-alpha - cerebrospinal fluid Whole Genome Sequencing Young Adult Zika Virus - classification Zika Virus - genetics Zika Virus - isolation & purification Zika Virus - pathogenicity Zika Virus Infection - complications Zika Virus Infection - diagnosis Zika Virus Infection - physiopathology Zika Virus Infection - virology |
| title | An observational clinical case of Zika virus-associated neurological disease is associated with primary IgG response and enhanced TNF levels |
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