Old Yellow Enzymes, Highly Homologous FMN Oxidoreductases with Modulating Roles in Oxidative Stress and Programmed Cell Death in Yeast

In a genetic screen to identify modifiers of Bax-dependent lethality in yeast, the C terminus of OYE2 was isolated based on its capacity to restore sensitivity to a Bax-resistant yeast mutant strain. Overexpression of full-length OYE2 suppresses Bax lethality in yeast, lowers endogenous reactive oxy...

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Veröffentlicht in:	The Journal of biological chemistry 2007-12, Vol.282 (49), p.36010-36023
Hauptverfasser:	Odat, Osama, Matta, Samer, Khalil, Hadi, Kampranis, Sotirios C., Pfau, Raymond, Tsichlis, Philip N., Makris, Antonios M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - genetics Actins - metabolism Amino Acid Sequence - genetics Amino Acid Substitution Apoptosis - drug effects Apoptosis - physiology bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Cytoskeleton - genetics Cytoskeleton - metabolism FMN Reductase - genetics FMN Reductase - metabolism Glutathione - genetics Glutathione - metabolism Hydrogen Peroxide - pharmacology Mutation, Missense Oxidants - pharmacology Oxidation-Reduction Oxidative Stress - drug effects Oxidative Stress - physiology Oxygen Consumption - drug effects Oxygen Consumption - physiology Reactive Oxygen Species - metabolism Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Sequence Deletion
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