Lineage restriction analyses in CHIP indicate myeloid bias for TET2 and multipotent stem cell origin for DNMT3A

We analyzed DNA from polymorphonuclear (PMN) cells, monocytes, B cells, and T cells of 107 individuals with clonal hematopoiesis of indeterminate potential (CHIP) to perform lineage restriction analysis of different gene mutations. Three lineage categories were defined: myeloid (PMN with or without...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Blood 2018-07, Vol.132 (3), p.277-280
Hauptverfasser:	Buscarlet, Manuel, Provost, Sylvie, Zada, Yassamin Feroz, Bourgoin, Vincent, Mollica, Luigina, Dubé, Marie-Pierre, Busque, Lambert
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biomarkers Cell Differentiation Cell Lineage - genetics Chromatin Immunoprecipitation Clonal Evolution - genetics DNA (Cytosine-5-)-Methyltransferases - genetics DNA-Binding Proteins - genetics Female High-Throughput Nucleotide Sequencing Humans Male Middle Aged Models, Biological Multipotent Stem Cells - metabolism Mutation Proto-Oncogene Proteins - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!