New insights into hypoxia-related mechanisms involved in different microvascular patterns of bronchopulmonary carcinoids and poorly differentiated neuroendocrine carcinomas. Role of ribonuclease T2 (RNASET2) and HIF-1α

Ribonuclease T2 (RNASET2) is a pleiotropic and polyfunctional protein, which exerts several different activities in neoplastic cells since the early steps of tumor development. Besides having an antitumorigenic activity, RNASET2 inhibits both bFGF-induced and VEGF-induced angiogenesis and has a role...

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Veröffentlicht in:	Human pathology 2018-09, Vol.79, p.66-76
Hauptverfasser:	Uccella, Silvia, La Rosa, Stefano, Scaldaferri, Debora, Monti, Laura, Maragliano, Roberta, Sorrenti, Elisa, Gariboldi, Marzia, Taramelli, Roberto, Sessa, Fausto, Acquati, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	Alarmin Apoptosis Biology HIF-1α Hypoxia Immunoglobulins Lung Lung cancer Medical prognosis Microvascular Density Neuroendocrine Neoplasms Ovarian cancer Proteins RNASET2 Tumors
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