KDM2B is a histone H3K79 demethylase and induces transcriptional repression via sirtuin‐1‐mediated chromatin silencing

ABSTRACT The methylation of histone H3 lysine 79 (H3K79) is an active chromatin marker and is prominent in actively transcribed regions of the genome; however, demethylase of H3K79 remains unknown despite intensive research. Here, we show that KDM2B, also known as FBXL10 and a member of the Jumonji...

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Veröffentlicht in:	The FASEB journal 2018-10, Vol.32 (10), p.5737-5750
Hauptverfasser:	Kang, Joo‐Young, Kim, Ji‐Young, Kim, Kee‐Beom, Park, Jin Woo, Cho, Hana, Hahm, Ja Young, Chae, Yun‐Cheol, Kim, Daehwan, Kook, Hyun, Rhee, Sangmyeong, Ha, Nam‐Chul, Seo, Sang‐Beom
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatin - genetics Chromatin - metabolism F-Box Proteins - genetics F-Box Proteins - metabolism Gene Silencing H3K79 methylation histone demethylase Homeodomain Proteins - biosynthesis Homeodomain Proteins - genetics Humans Jumonji Domain-Containing Histone Demethylases - genetics Jumonji Domain-Containing Histone Demethylases - metabolism K562 Cells Myeloid Ecotropic Viral Integration Site 1 Protein - biosynthesis Myeloid Ecotropic Viral Integration Site 1 Protein - genetics SIRT1 Sirtuin 1 - genetics Sirtuin 1 - metabolism transcription Transcription, Genetic
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