Astrocyte-derived kynurenic acid modulates basal and evoked cortical acetylcholine release

We tested the hypothesis that fluctuations in the levels of kynurenic acid (KYNA), an endogenous antagonist of the α7 nicotinic acetylcholine (ACh) receptor, modulate extracellular ACh levels in the medial prefrontal cortex in rats. Decreases in cortical KYNA levels were achieved by local perfusion...

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Veröffentlicht in:	The European journal of neuroscience 2009-02, Vol.29 (3), p.529-538
Hauptverfasser:	Zmarowski, A., Wu, H.-Q., Brooks, J. M., Potter, M. C., Pellicciari, R., Schwarcz, R., Bruno, J. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Acetylcholine - secretion alpha7 Nicotinic Acetylcholine Receptor amphetamine Amphetamine - pharmacology Animals Astrocytes - drug effects Astrocytes - metabolism Astrocytes - secretion Central Nervous System Stimulants - pharmacology Cerebral Cortex - drug effects Cerebral Cortex - metabolism Enzyme Inhibitors - pharmacology glia Kynurenic Acid - antagonists & inhibitors Kynurenic Acid - metabolism Male microdialysis Nicotinic Antagonists - metabolism Nicotinic Antagonists - pharmacology prefrontal cortex Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Presynaptic Terminals - drug effects Presynaptic Terminals - metabolism Presynaptic Terminals - secretion Rats Rats, Wistar Receptors, Nicotinic - drug effects Receptors, Nicotinic - metabolism schizophrenia Schizophrenia - drug therapy Schizophrenia - metabolism Schizophrenia - physiopathology Synaptic Transmission - drug effects Synaptic Transmission - physiology Transaminases - antagonists & inhibitors Transaminases - metabolism Up-Regulation - drug effects Up-Regulation - physiology
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