PRKAR2B promotes prostate cancer metastasis by activating Wnt/β‐catenin and inducing epithelial‐mesenchymal transition

Castration‐resistant prostate cancers (CRPC) that occur after the failure of androgen‐blocking therapies cause most of the deaths in prostate cancer (PCa) patients. In a previous study we identified that PRKAR2B expression is upregulated in CRPC and possesses potentials to develop CRPC. Here we furt...

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Veröffentlicht in:	Journal of cellular biochemistry 2018-09, Vol.119 (9), p.7319-7327
Hauptverfasser:	Sha, Jianjun, Han, Qing, Chi, Chenfei, Zhu, Yinjie, Pan, Jiahua, Dong, Baijun, Huang, Yiran, Xia, Weiliang, Xue, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens Cancer Castration Catenin CRPC E-cadherin epithelial‐mesenchymal transition Fibronectin Lymph nodes Mesenchyme Metastases Metastasis PRKAR2B Prostate cancer Vimentin Wnt Wnt protein
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