Locking the nontemplate DNA to control transcription

Summary Universally conserved NusG/Spt5 factors reduce RNA polymerase pausing and arrest. In a widely accepted model, these proteins bridge the RNA polymerase clamp and lobe domains across the DNA channel, inhibiting the clamp opening to promote pause‐free RNA synthesis. However, recent structures o...

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Veröffentlicht in:	Molecular microbiology 2018-08, Vol.109 (4), p.445-457
Hauptverfasser:	Nedialkov, Yuri, Svetlov, Dmitri, Belogurov, Georgiy A., Artsimovitch, Irina
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromosomal Proteins, Non-Histone - metabolism Deoxyribonucleic acid DNA DNA, Bacterial - genetics DNA-directed RNA polymerase DNA-Directed RNA Polymerases - metabolism Domains E coli Elongated structure Escherichia coli - genetics Escherichia coli Proteins - metabolism Exonuclease Nucleic Acid Conformation Peptide Elongation Factors - metabolism Proteins Ribonucleic acid RNA RNA polymerase RNA, Bacterial - biosynthesis Trans-Activators - metabolism Transcription elongation Transcription Factors - metabolism Transcription, Genetic - genetics Transcription, Genetic - physiology Transcriptional Elongation Factors - metabolism Translocation
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