The intranuclear PEX domain of MMP involves proliferation, migration, and metastasis of aggressive adenocarcinoma cells

Members of matrix metalloproteinase (MMP) family promote cancer cell migration, invasion, and metastasis through alteration of the tumor milieu, intracellular signaling pathways, and transcription. We examined gene expression signatures of colon adenocarcinoma cell lines with different metastatic po...

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Veröffentlicht in:	Journal of cellular biochemistry 2018-09, Vol.119 (9), p.7363-7376
Hauptverfasser:	Okusha, Yuka, Eguchi, Takanori, Sogawa, Chiharu, Okui, Tatsuo, Nakano, Keisuke, Okamoto, Kuniaki, Kozaki, Ken‐Ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Cancer cancer metastasis Cell adhesion & migration Cell migration Cell proliferation Colon Gelatinase B Gene expression Intracellular signalling Isoforms Localization Lungs Matrix metalloproteinase Metalloproteinase Metastases Metastasis non‐proteolytic MMP nuclear MMP Nuclei (cytology) PEX domain Proteolysis Stroma Stromelysin 1 Transcription Tumor cell lines tumor stroma Tumors
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