Depression-resistant Phenotype in Mice Overexpressing Regulator of G Protein Signaling 8 (RGS8)

•RGS8 transgenic mice (RGS8tg) overexpressing RGS8 protein in the hippocampal CA1 exhibit antidepressant-like behavior.•Desipramine treatment further reduced the immobility time in RGS8tg in the forced swimming test.•Administration of MCHR1 antagonist SNAP94847 to RGS8tg had no effect on the immobil...

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Veröffentlicht in:	Neuroscience 2018-07, Vol.383, p.160-169
Hauptverfasser:	Kobayashi, Yuki, Takemoto, Risa, Yamato, Shogo, Okada, Tomoya, Iijima, Michihiko, Uematsu, Yoshikatsu, Chaki, Shigeyuki, Saito, Yumiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CA1 Region, Hippocampal - metabolism depression Depression - etiology Depression - metabolism desipramine Male melanin-concentrating hormone receptor 1 Mice Mice, Inbred C57BL Mice, Transgenic Phenotype primary cilia Receptors, Somatostatin - metabolism RGS Proteins - genetics RGS Proteins - metabolism RGS8 Stress, Psychological - complications
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