Effect of dietary α‐ketoglutarate and allicin supplementation on the composition and diversity of the cecal microbial community in growing pigs
BACKGROUND The search for substitutes for antibiotics has recently become urgent. In our previous work, dietary α‐ketoglutarate (AKG) combined with allicin improved growth performance and enhanced immunity in growing pigs, whereas the effects on them of intestinal microbiota were unclear. Here, we f...
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| Veröffentlicht in: | Journal of the science of food and agriculture 2018-12, Vol.98 (15), p.5816-5821 |
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| creator | Liu, Shaojuan He, Liuqin Jiang, Qian Duraipandiyan, Veeramuthu Al‐Dhabi, Naif A Liu, Gang Yao, Kang Yin, Yulong |
| description | BACKGROUND
The search for substitutes for antibiotics has recently become urgent. In our previous work, dietary α‐ketoglutarate (AKG) combined with allicin improved growth performance and enhanced immunity in growing pigs, whereas the effects on them of intestinal microbiota were unclear. Here, we further investigate the effects of dietary AKG and allicin supplementation on the composition and diversity of intestinal microbiota in growing pigs.
RESULTS
Treatment with a combination of AKG and allicin enhanced cecal bacteria richness and diversity, as evidenced by changes in Chao 1, ACE, Shannon, and Simpson values when compared to the control group and antibiotics group. At the phylum level, Bacteroidetes and Firmicutes were the two most abundant phyla. Treatment with a combination of AKG and allicin increased the numbers of Firmicutes and reduced the numbers of Bacteroidetes. Prevotella was the most abundant genus; it was increased by treatment with a combination of AKG and allicin. Furthermore, compared with the antibiotic group, the level of acetate was increased in the AKG group with or without allicin. Treatment with a combination of AKG and allicin increased the levels of cecal butyrate and total volatile fatty acids (VFA) when compared with the control group in growing pigs.
CONCLUSION
Dietary 1.0% AKG combined with 0.5% allicin improved cecal microbial composition and diversity, which might further promote VFA metabolism in growing pigs. © 2018 Society of Chemical Industry |
| doi_str_mv | 10.1002/jsfa.9131 |
| format | Article |
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The search for substitutes for antibiotics has recently become urgent. In our previous work, dietary α‐ketoglutarate (AKG) combined with allicin improved growth performance and enhanced immunity in growing pigs, whereas the effects on them of intestinal microbiota were unclear. Here, we further investigate the effects of dietary AKG and allicin supplementation on the composition and diversity of intestinal microbiota in growing pigs.
RESULTS
Treatment with a combination of AKG and allicin enhanced cecal bacteria richness and diversity, as evidenced by changes in Chao 1, ACE, Shannon, and Simpson values when compared to the control group and antibiotics group. At the phylum level, Bacteroidetes and Firmicutes were the two most abundant phyla. Treatment with a combination of AKG and allicin increased the numbers of Firmicutes and reduced the numbers of Bacteroidetes. Prevotella was the most abundant genus; it was increased by treatment with a combination of AKG and allicin. Furthermore, compared with the antibiotic group, the level of acetate was increased in the AKG group with or without allicin. Treatment with a combination of AKG and allicin increased the levels of cecal butyrate and total volatile fatty acids (VFA) when compared with the control group in growing pigs.
CONCLUSION
Dietary 1.0% AKG combined with 0.5% allicin improved cecal microbial composition and diversity, which might further promote VFA metabolism in growing pigs. © 2018 Society of Chemical Industry</description><identifier>ISSN: 0022-5142</identifier><identifier>EISSN: 1097-0010</identifier><identifier>DOI: 10.1002/jsfa.9131</identifier><identifier>PMID: 29756325</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Acetic acid ; allicin ; Antibiotics ; Bacteroidetes ; Cecum ; Composition ; Diet ; Dietary supplements ; Fatty acids ; Firmicutes ; growing pigs ; Immunity ; Intestinal microflora ; Intestine ; Ketoglutaric acid ; Metabolism ; microbial community composition and diversity ; Microbiota ; Microorganisms ; Organic chemistry ; Plasma ; Prevotellaceae ; Volatile fatty acids ; α‐ketoglutarate</subject><ispartof>Journal of the science of food and agriculture, 2018-12, Vol.98 (15), p.5816-5821</ispartof><rights>2018 Society of Chemical Industry</rights><rights>2018 Society of Chemical Industry.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3531-2ffbefd7672e706bbc5f7d85293f0b21eab5d8fcb61ccc8bbe790a7b89523e5e3</citedby><cites>FETCH-LOGICAL-c3531-2ffbefd7672e706bbc5f7d85293f0b21eab5d8fcb61ccc8bbe790a7b89523e5e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjsfa.9131$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjsfa.9131$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29756325$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Shaojuan</creatorcontrib><creatorcontrib>He, Liuqin</creatorcontrib><creatorcontrib>Jiang, Qian</creatorcontrib><creatorcontrib>Duraipandiyan, Veeramuthu</creatorcontrib><creatorcontrib>Al‐Dhabi, Naif A</creatorcontrib><creatorcontrib>Liu, Gang</creatorcontrib><creatorcontrib>Yao, Kang</creatorcontrib><creatorcontrib>Yin, Yulong</creatorcontrib><title>Effect of dietary α‐ketoglutarate and allicin supplementation on the composition and diversity of the cecal microbial community in growing pigs</title><title>Journal of the science of food and agriculture</title><addtitle>J Sci Food Agric</addtitle><description>BACKGROUND
The search for substitutes for antibiotics has recently become urgent. In our previous work, dietary α‐ketoglutarate (AKG) combined with allicin improved growth performance and enhanced immunity in growing pigs, whereas the effects on them of intestinal microbiota were unclear. Here, we further investigate the effects of dietary AKG and allicin supplementation on the composition and diversity of intestinal microbiota in growing pigs.
RESULTS
Treatment with a combination of AKG and allicin enhanced cecal bacteria richness and diversity, as evidenced by changes in Chao 1, ACE, Shannon, and Simpson values when compared to the control group and antibiotics group. At the phylum level, Bacteroidetes and Firmicutes were the two most abundant phyla. Treatment with a combination of AKG and allicin increased the numbers of Firmicutes and reduced the numbers of Bacteroidetes. Prevotella was the most abundant genus; it was increased by treatment with a combination of AKG and allicin. Furthermore, compared with the antibiotic group, the level of acetate was increased in the AKG group with or without allicin. Treatment with a combination of AKG and allicin increased the levels of cecal butyrate and total volatile fatty acids (VFA) when compared with the control group in growing pigs.
CONCLUSION
Dietary 1.0% AKG combined with 0.5% allicin improved cecal microbial composition and diversity, which might further promote VFA metabolism in growing pigs. © 2018 Society of Chemical Industry</description><subject>Acetic acid</subject><subject>allicin</subject><subject>Antibiotics</subject><subject>Bacteroidetes</subject><subject>Cecum</subject><subject>Composition</subject><subject>Diet</subject><subject>Dietary supplements</subject><subject>Fatty acids</subject><subject>Firmicutes</subject><subject>growing pigs</subject><subject>Immunity</subject><subject>Intestinal microflora</subject><subject>Intestine</subject><subject>Ketoglutaric acid</subject><subject>Metabolism</subject><subject>microbial community composition and diversity</subject><subject>Microbiota</subject><subject>Microorganisms</subject><subject>Organic chemistry</subject><subject>Plasma</subject><subject>Prevotellaceae</subject><subject>Volatile fatty acids</subject><subject>α‐ketoglutarate</subject><issn>0022-5142</issn><issn>1097-0010</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kc9uFSEUh4nR2NvqwhcwJG7sYlr-yDAsm6bVmiZdqGsCzOHKlRnGYcbm7nwE45v4Ij6ET1Lm3uqiiQkJcPj4AueH0AtKTigh7HSTvTlRlNNHaEWJkhUhlDxGq3LGKkHfsAN0mPOGEKJUXT9FB0xJUXMmVujnhffgJpw8bgNMZtzi37_-fP_xBaa0jnMpmAmw6VtsYgwu9DjPwxChg34yU0g9LmP6DNilbkg57EoL3oZvMJb9dlHvAHAm4i64MdlQVuVCN_cLUKTrMd2Gfo2HsM7P0BNvYobn9_MR-nR58fH8XXV98_bq_Oy6clxwWjHvLfhW1pKBJLW1TnjZNoIp7ollFIwVbeOdralzrrEWpCJG2kYJxkEAP0Kv995hTF9nyJPuQnYQo-khzVkzwhtJBGOyoK8eoJs0j315nWal7TVvVC0KdbynyhdzHsHrYQxdaammRC9B6SUovQRV2Jf3xtl20P4j_yZTgNM9cBsibP9v0u8_XJ7tlHeP7aKu</recordid><startdate>201812</startdate><enddate>201812</enddate><creator>Liu, Shaojuan</creator><creator>He, Liuqin</creator><creator>Jiang, Qian</creator><creator>Duraipandiyan, Veeramuthu</creator><creator>Al‐Dhabi, Naif A</creator><creator>Liu, Gang</creator><creator>Yao, Kang</creator><creator>Yin, Yulong</creator><general>John Wiley & Sons, Ltd</general><general>John Wiley and Sons, Limited</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QL</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7ST</scope><scope>7T5</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>201812</creationdate><title>Effect of dietary α‐ketoglutarate and allicin supplementation on the composition and diversity of the cecal microbial community in growing pigs</title><author>Liu, Shaojuan ; He, Liuqin ; Jiang, Qian ; Duraipandiyan, Veeramuthu ; Al‐Dhabi, Naif A ; Liu, Gang ; Yao, Kang ; Yin, Yulong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3531-2ffbefd7672e706bbc5f7d85293f0b21eab5d8fcb61ccc8bbe790a7b89523e5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acetic acid</topic><topic>allicin</topic><topic>Antibiotics</topic><topic>Bacteroidetes</topic><topic>Cecum</topic><topic>Composition</topic><topic>Diet</topic><topic>Dietary supplements</topic><topic>Fatty acids</topic><topic>Firmicutes</topic><topic>growing pigs</topic><topic>Immunity</topic><topic>Intestinal microflora</topic><topic>Intestine</topic><topic>Ketoglutaric acid</topic><topic>Metabolism</topic><topic>microbial community composition and diversity</topic><topic>Microbiota</topic><topic>Microorganisms</topic><topic>Organic chemistry</topic><topic>Plasma</topic><topic>Prevotellaceae</topic><topic>Volatile fatty acids</topic><topic>α‐ketoglutarate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Shaojuan</creatorcontrib><creatorcontrib>He, Liuqin</creatorcontrib><creatorcontrib>Jiang, Qian</creatorcontrib><creatorcontrib>Duraipandiyan, Veeramuthu</creatorcontrib><creatorcontrib>Al‐Dhabi, Naif A</creatorcontrib><creatorcontrib>Liu, Gang</creatorcontrib><creatorcontrib>Yao, Kang</creatorcontrib><creatorcontrib>Yin, Yulong</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the science of food and agriculture</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Shaojuan</au><au>He, Liuqin</au><au>Jiang, Qian</au><au>Duraipandiyan, Veeramuthu</au><au>Al‐Dhabi, Naif A</au><au>Liu, Gang</au><au>Yao, Kang</au><au>Yin, Yulong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of dietary α‐ketoglutarate and allicin supplementation on the composition and diversity of the cecal microbial community in growing pigs</atitle><jtitle>Journal of the science of food and agriculture</jtitle><addtitle>J Sci Food Agric</addtitle><date>2018-12</date><risdate>2018</risdate><volume>98</volume><issue>15</issue><spage>5816</spage><epage>5821</epage><pages>5816-5821</pages><issn>0022-5142</issn><eissn>1097-0010</eissn><abstract>BACKGROUND
The search for substitutes for antibiotics has recently become urgent. In our previous work, dietary α‐ketoglutarate (AKG) combined with allicin improved growth performance and enhanced immunity in growing pigs, whereas the effects on them of intestinal microbiota were unclear. Here, we further investigate the effects of dietary AKG and allicin supplementation on the composition and diversity of intestinal microbiota in growing pigs.
RESULTS
Treatment with a combination of AKG and allicin enhanced cecal bacteria richness and diversity, as evidenced by changes in Chao 1, ACE, Shannon, and Simpson values when compared to the control group and antibiotics group. At the phylum level, Bacteroidetes and Firmicutes were the two most abundant phyla. Treatment with a combination of AKG and allicin increased the numbers of Firmicutes and reduced the numbers of Bacteroidetes. Prevotella was the most abundant genus; it was increased by treatment with a combination of AKG and allicin. Furthermore, compared with the antibiotic group, the level of acetate was increased in the AKG group with or without allicin. Treatment with a combination of AKG and allicin increased the levels of cecal butyrate and total volatile fatty acids (VFA) when compared with the control group in growing pigs.
CONCLUSION
Dietary 1.0% AKG combined with 0.5% allicin improved cecal microbial composition and diversity, which might further promote VFA metabolism in growing pigs. © 2018 Society of Chemical Industry</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>29756325</pmid><doi>10.1002/jsfa.9131</doi><tpages>6</tpages></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Acetic acid allicin Antibiotics Bacteroidetes Cecum Composition Diet Dietary supplements Fatty acids Firmicutes growing pigs Immunity Intestinal microflora Intestine Ketoglutaric acid Metabolism microbial community composition and diversity Microbiota Microorganisms Organic chemistry Plasma Prevotellaceae Volatile fatty acids α‐ketoglutarate |
| title | Effect of dietary α‐ketoglutarate and allicin supplementation on the composition and diversity of the cecal microbial community in growing pigs |
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