The VEGFA ‐1154G/A polymorphism is associated with reduced risk of rheumatoid arthritis but not with systemic lupus erythematosus in Mexican women
Background Levels of circulating vascular endothelial growth factor (VEGF) (a potent endothelial‐cell‐specific angiogenic factor) have been correlated with disease activity in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). In addition, several single nucleotide polym...
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| Veröffentlicht in: | The journal of gene medicine 2018-06, Vol.20 (6), p.e3024-n/a |
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| creator | Ramírez‐Bello, Julian Cadena‐Sandoval, Daniel Fragoso, José Manuel Barbosa‐Cobos, Rosa Elda Moreno‐Eutímio, Mario Adán Saavedra‐Salinas, Miguel Ángel Valencia‐Pacheco, Guillermo López‐Villanueva, Ricardo F. Jiménez‐Morales, Silvia |
| description | Background
Levels of circulating vascular endothelial growth factor (VEGF) (a potent endothelial‐cell‐specific angiogenic factor) have been correlated with disease activity in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). In addition, several single nucleotide polymorphisms (SNPs), including the VEGFA ‐2578C/A, have been associated with RA in some populations. By contrast, the role of different VEGFA SNPs in the susceptibility to SLE has received little attention. Thus, the present study aimed to determine whether the VEGFA ‐2578C/A, −1154G/A and ‐634G/C polymorphisms confer risk or were associated with reduced risk of RA or SLE in a Mexican population.
Methods
The present study included 903 women from Mexico: 405 were patients with RA, 282 had SLE and 216 were healthy individuals. The genotypes were obtained with TaqMan probes.
Results
The data obtained in the present study suggest that the VEGFA ‐2578C/A and ‐634G/C polymorphisms are not risk factors for RA or SLE; however, VEGFA ‐1154G/A was associated with reduced risk in women with RA (odds ratio = 0.6, pc = 0.0051) but not with SLE (odds ratio = 0.7, pc = 0.13).
Conclusions
The present study is the first to document an association between VEGFA ‐1154G/A and reduced risk in women with RA but not with SLE. |
| doi_str_mv | 10.1002/jgm.3024 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2038705087</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2038705087</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3494-ad5fd6b5c1d68a4b7156388e0258b283e78759ea7732686bfa98c00b8fe461103</originalsourceid><addsrcrecordid>eNp1kcFu1DAURS1ERUtB4guQJTbdpLUdO3aWo6qdglp1UxC7yHFeiIckDrajITs-oQu-kC_B0ylUQmL1_KRzj558EXpDySklhJ1tvgynOWH8GTqigtGMMcGfpzcpy4yX6vMhehnChhAqlSpfoENWSlFwmh-hn3cd4E8X68sV_vXjnlLB12crPLl-GZyfOhsGbAPWIThjdYQGb23ssIdmNmnxNnzFrsW-g3nQ0dkGax87b2MK1XPEo4v7RFhChMEa3M_THDD4JXawi4S02RHfwHdr9Ii3boDxFTpodR_g9eM8Rh8vL-7Or7Lr2_X789V1ZnJe8kw3om2KWhjaFErzWlJR5EoBYULVTOUglRQlaClzVqiibnWpDCG1aoEXlJL8GJ3svZN332YIsRpsMND3egQ3h4qRXEkiiJIJffcPunGzH9N1iRIyfSwj8klovAvBQ1tN3g7aLxUl1a6pKjVV7ZpK6NtH4VwP0PwF_1STgGwPbG0Py39F1Yf1zYPwN8OYneY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2057178207</pqid></control><display><type>article</type><title>The VEGFA ‐1154G/A polymorphism is associated with reduced risk of rheumatoid arthritis but not with systemic lupus erythematosus in Mexican women</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Ramírez‐Bello, Julian ; Cadena‐Sandoval, Daniel ; Fragoso, José Manuel ; Barbosa‐Cobos, Rosa Elda ; Moreno‐Eutímio, Mario Adán ; Saavedra‐Salinas, Miguel Ángel ; Valencia‐Pacheco, Guillermo ; López‐Villanueva, Ricardo F. ; Jiménez‐Morales, Silvia</creator><creatorcontrib>Ramírez‐Bello, Julian ; Cadena‐Sandoval, Daniel ; Fragoso, José Manuel ; Barbosa‐Cobos, Rosa Elda ; Moreno‐Eutímio, Mario Adán ; Saavedra‐Salinas, Miguel Ángel ; Valencia‐Pacheco, Guillermo ; López‐Villanueva, Ricardo F. ; Jiménez‐Morales, Silvia</creatorcontrib><description>Background
Levels of circulating vascular endothelial growth factor (VEGF) (a potent endothelial‐cell‐specific angiogenic factor) have been correlated with disease activity in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). In addition, several single nucleotide polymorphisms (SNPs), including the VEGFA ‐2578C/A, have been associated with RA in some populations. By contrast, the role of different VEGFA SNPs in the susceptibility to SLE has received little attention. Thus, the present study aimed to determine whether the VEGFA ‐2578C/A, −1154G/A and ‐634G/C polymorphisms confer risk or were associated with reduced risk of RA or SLE in a Mexican population.
Methods
The present study included 903 women from Mexico: 405 were patients with RA, 282 had SLE and 216 were healthy individuals. The genotypes were obtained with TaqMan probes.
Results
The data obtained in the present study suggest that the VEGFA ‐2578C/A and ‐634G/C polymorphisms are not risk factors for RA or SLE; however, VEGFA ‐1154G/A was associated with reduced risk in women with RA (odds ratio = 0.6, pc = 0.0051) but not with SLE (odds ratio = 0.7, pc = 0.13).
Conclusions
The present study is the first to document an association between VEGFA ‐1154G/A and reduced risk in women with RA but not with SLE.</description><identifier>ISSN: 1099-498X</identifier><identifier>EISSN: 1521-2254</identifier><identifier>DOI: 10.1002/jgm.3024</identifier><identifier>PMID: 29756413</identifier><language>eng</language><publisher>England: Wiley Periodicals Inc</publisher><subject>Angiogenesis ; Background levels ; Gene polymorphism ; Gene therapy ; Health risk assessment ; Lupus ; polymorphism ; Population studies ; Rheumatoid arthritis ; Risk factors ; Single-nucleotide polymorphism ; Systemic lupus erythematosus ; Vascular endothelial growth factor ; VEGFA gene</subject><ispartof>The journal of gene medicine, 2018-06, Vol.20 (6), p.e3024-n/a</ispartof><rights>Copyright © 2018 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3494-ad5fd6b5c1d68a4b7156388e0258b283e78759ea7732686bfa98c00b8fe461103</citedby><cites>FETCH-LOGICAL-c3494-ad5fd6b5c1d68a4b7156388e0258b283e78759ea7732686bfa98c00b8fe461103</cites><orcidid>0000-0002-4153-9315</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjgm.3024$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjgm.3024$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29756413$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramírez‐Bello, Julian</creatorcontrib><creatorcontrib>Cadena‐Sandoval, Daniel</creatorcontrib><creatorcontrib>Fragoso, José Manuel</creatorcontrib><creatorcontrib>Barbosa‐Cobos, Rosa Elda</creatorcontrib><creatorcontrib>Moreno‐Eutímio, Mario Adán</creatorcontrib><creatorcontrib>Saavedra‐Salinas, Miguel Ángel</creatorcontrib><creatorcontrib>Valencia‐Pacheco, Guillermo</creatorcontrib><creatorcontrib>López‐Villanueva, Ricardo F.</creatorcontrib><creatorcontrib>Jiménez‐Morales, Silvia</creatorcontrib><title>The VEGFA ‐1154G/A polymorphism is associated with reduced risk of rheumatoid arthritis but not with systemic lupus erythematosus in Mexican women</title><title>The journal of gene medicine</title><addtitle>J Gene Med</addtitle><description>Background
Levels of circulating vascular endothelial growth factor (VEGF) (a potent endothelial‐cell‐specific angiogenic factor) have been correlated with disease activity in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). In addition, several single nucleotide polymorphisms (SNPs), including the VEGFA ‐2578C/A, have been associated with RA in some populations. By contrast, the role of different VEGFA SNPs in the susceptibility to SLE has received little attention. Thus, the present study aimed to determine whether the VEGFA ‐2578C/A, −1154G/A and ‐634G/C polymorphisms confer risk or were associated with reduced risk of RA or SLE in a Mexican population.
Methods
The present study included 903 women from Mexico: 405 were patients with RA, 282 had SLE and 216 were healthy individuals. The genotypes were obtained with TaqMan probes.
Results
The data obtained in the present study suggest that the VEGFA ‐2578C/A and ‐634G/C polymorphisms are not risk factors for RA or SLE; however, VEGFA ‐1154G/A was associated with reduced risk in women with RA (odds ratio = 0.6, pc = 0.0051) but not with SLE (odds ratio = 0.7, pc = 0.13).
Conclusions
The present study is the first to document an association between VEGFA ‐1154G/A and reduced risk in women with RA but not with SLE.</description><subject>Angiogenesis</subject><subject>Background levels</subject><subject>Gene polymorphism</subject><subject>Gene therapy</subject><subject>Health risk assessment</subject><subject>Lupus</subject><subject>polymorphism</subject><subject>Population studies</subject><subject>Rheumatoid arthritis</subject><subject>Risk factors</subject><subject>Single-nucleotide polymorphism</subject><subject>Systemic lupus erythematosus</subject><subject>Vascular endothelial growth factor</subject><subject>VEGFA gene</subject><issn>1099-498X</issn><issn>1521-2254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kcFu1DAURS1ERUtB4guQJTbdpLUdO3aWo6qdglp1UxC7yHFeiIckDrajITs-oQu-kC_B0ylUQmL1_KRzj558EXpDySklhJ1tvgynOWH8GTqigtGMMcGfpzcpy4yX6vMhehnChhAqlSpfoENWSlFwmh-hn3cd4E8X68sV_vXjnlLB12crPLl-GZyfOhsGbAPWIThjdYQGb23ssIdmNmnxNnzFrsW-g3nQ0dkGax87b2MK1XPEo4v7RFhChMEa3M_THDD4JXawi4S02RHfwHdr9Ii3boDxFTpodR_g9eM8Rh8vL-7Or7Lr2_X789V1ZnJe8kw3om2KWhjaFErzWlJR5EoBYULVTOUglRQlaClzVqiibnWpDCG1aoEXlJL8GJ3svZN332YIsRpsMND3egQ3h4qRXEkiiJIJffcPunGzH9N1iRIyfSwj8klovAvBQ1tN3g7aLxUl1a6pKjVV7ZpK6NtH4VwP0PwF_1STgGwPbG0Py39F1Yf1zYPwN8OYneY</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Ramírez‐Bello, Julian</creator><creator>Cadena‐Sandoval, Daniel</creator><creator>Fragoso, José Manuel</creator><creator>Barbosa‐Cobos, Rosa Elda</creator><creator>Moreno‐Eutímio, Mario Adán</creator><creator>Saavedra‐Salinas, Miguel Ángel</creator><creator>Valencia‐Pacheco, Guillermo</creator><creator>López‐Villanueva, Ricardo F.</creator><creator>Jiménez‐Morales, Silvia</creator><general>Wiley Periodicals Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4153-9315</orcidid></search><sort><creationdate>201806</creationdate><title>The VEGFA ‐1154G/A polymorphism is associated with reduced risk of rheumatoid arthritis but not with systemic lupus erythematosus in Mexican women</title><author>Ramírez‐Bello, Julian ; Cadena‐Sandoval, Daniel ; Fragoso, José Manuel ; Barbosa‐Cobos, Rosa Elda ; Moreno‐Eutímio, Mario Adán ; Saavedra‐Salinas, Miguel Ángel ; Valencia‐Pacheco, Guillermo ; López‐Villanueva, Ricardo F. ; Jiménez‐Morales, Silvia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3494-ad5fd6b5c1d68a4b7156388e0258b283e78759ea7732686bfa98c00b8fe461103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Angiogenesis</topic><topic>Background levels</topic><topic>Gene polymorphism</topic><topic>Gene therapy</topic><topic>Health risk assessment</topic><topic>Lupus</topic><topic>polymorphism</topic><topic>Population studies</topic><topic>Rheumatoid arthritis</topic><topic>Risk factors</topic><topic>Single-nucleotide polymorphism</topic><topic>Systemic lupus erythematosus</topic><topic>Vascular endothelial growth factor</topic><topic>VEGFA gene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramírez‐Bello, Julian</creatorcontrib><creatorcontrib>Cadena‐Sandoval, Daniel</creatorcontrib><creatorcontrib>Fragoso, José Manuel</creatorcontrib><creatorcontrib>Barbosa‐Cobos, Rosa Elda</creatorcontrib><creatorcontrib>Moreno‐Eutímio, Mario Adán</creatorcontrib><creatorcontrib>Saavedra‐Salinas, Miguel Ángel</creatorcontrib><creatorcontrib>Valencia‐Pacheco, Guillermo</creatorcontrib><creatorcontrib>López‐Villanueva, Ricardo F.</creatorcontrib><creatorcontrib>Jiménez‐Morales, Silvia</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of gene medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramírez‐Bello, Julian</au><au>Cadena‐Sandoval, Daniel</au><au>Fragoso, José Manuel</au><au>Barbosa‐Cobos, Rosa Elda</au><au>Moreno‐Eutímio, Mario Adán</au><au>Saavedra‐Salinas, Miguel Ángel</au><au>Valencia‐Pacheco, Guillermo</au><au>López‐Villanueva, Ricardo F.</au><au>Jiménez‐Morales, Silvia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The VEGFA ‐1154G/A polymorphism is associated with reduced risk of rheumatoid arthritis but not with systemic lupus erythematosus in Mexican women</atitle><jtitle>The journal of gene medicine</jtitle><addtitle>J Gene Med</addtitle><date>2018-06</date><risdate>2018</risdate><volume>20</volume><issue>6</issue><spage>e3024</spage><epage>n/a</epage><pages>e3024-n/a</pages><issn>1099-498X</issn><eissn>1521-2254</eissn><abstract>Background
Levels of circulating vascular endothelial growth factor (VEGF) (a potent endothelial‐cell‐specific angiogenic factor) have been correlated with disease activity in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). In addition, several single nucleotide polymorphisms (SNPs), including the VEGFA ‐2578C/A, have been associated with RA in some populations. By contrast, the role of different VEGFA SNPs in the susceptibility to SLE has received little attention. Thus, the present study aimed to determine whether the VEGFA ‐2578C/A, −1154G/A and ‐634G/C polymorphisms confer risk or were associated with reduced risk of RA or SLE in a Mexican population.
Methods
The present study included 903 women from Mexico: 405 were patients with RA, 282 had SLE and 216 were healthy individuals. The genotypes were obtained with TaqMan probes.
Results
The data obtained in the present study suggest that the VEGFA ‐2578C/A and ‐634G/C polymorphisms are not risk factors for RA or SLE; however, VEGFA ‐1154G/A was associated with reduced risk in women with RA (odds ratio = 0.6, pc = 0.0051) but not with SLE (odds ratio = 0.7, pc = 0.13).
Conclusions
The present study is the first to document an association between VEGFA ‐1154G/A and reduced risk in women with RA but not with SLE.</abstract><cop>England</cop><pub>Wiley Periodicals Inc</pub><pmid>29756413</pmid><doi>10.1002/jgm.3024</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-4153-9315</orcidid></addata></record> |
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| ispartof | The journal of gene medicine, 2018-06, Vol.20 (6), p.e3024-n/a |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Angiogenesis Background levels Gene polymorphism Gene therapy Health risk assessment Lupus polymorphism Population studies Rheumatoid arthritis Risk factors Single-nucleotide polymorphism Systemic lupus erythematosus Vascular endothelial growth factor VEGFA gene |
| title | The VEGFA ‐1154G/A polymorphism is associated with reduced risk of rheumatoid arthritis but not with systemic lupus erythematosus in Mexican women |
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