Behavioural Pharmacology: GABAB receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice

Behavioural Pharmacology: GABAB receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice

In this study, we investigated the effects of GABAA and GABAB receptor agonists on the methamphetamine-induced impairment of recognition memory in mice. Repeated treatment with methamphetamine at a dose of 1 mg/kg for 7 days induced an impairment of recognition memory. Baclofen, a GABAB receptor ago...

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Veröffentlicht in:European journal of pharmacology 2009-01, Vol.602 (1), p.101-104
Hauptverfasser: Arai, Sawako, Takuma, Kazuhiro, Mizoguchi, Hiroyuki, Ibi, Daisuke, Nagai, Taku, Kamei, Hiroyuki, Kim, Hyoung-Chun, Yamada, Kiyofumi
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container_issue 1
container_start_page 101
container_title European journal of pharmacology
container_volume 602
creator Arai, Sawako
Takuma, Kazuhiro
Mizoguchi, Hiroyuki
Ibi, Daisuke
Nagai, Taku
Kamei, Hiroyuki
Kim, Hyoung-Chun
Yamada, Kiyofumi
description In this study, we investigated the effects of GABAA and GABAB receptor agonists on the methamphetamine-induced impairment of recognition memory in mice. Repeated treatment with methamphetamine at a dose of 1 mg/kg for 7 days induced an impairment of recognition memory. Baclofen, a GABAB receptor agonist, ameliorated the repeated methamphetamine-induced cognitive impairment, although gaboxadol, a GABAA receptor agonist, had no significant effect. GABAB receptors may constitute a putative new target in treating cognitive deficits in patients suffering from schizophrenia, as well as methamphetamine psychosis.
doi_str_mv 10.1016/j.ejphar.2008.10.065
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title Behavioural Pharmacology: GABAB receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice
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