Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease

Curcuminoids (a mixture of curcumin, bisdemethoxycurcumin and demethoxycurcumin) share vital pharmacological properties possessed by turmeric, a well known curry spice, considered useful in Alzheimer's disease (AD). The aim of this study was to evaluate if curcuminoids possess acetylcholinester...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2009-02, Vol.91 (4), p.554-559
Hauptverfasser:	Ahmed, Touqeer, Gilani, Anwarul-Hassan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism Acetylcholinesterase inhibitors Adult and adolescent clinical studies Alzheimer Disease - drug therapy Alzheimer Disease - psychology Alzheimer's disease Amnesia - chemically induced Amnesia - psychology Animals Biological and medical sciences Bisdemethoxycurcumin Cholinesterase Inhibitors Curcuma Curcuma longa Curcumin Curcumin - analogs & derivatives Curcumin - pharmacology Curcuminoids Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes Dose-Response Relationship, Drug Hippocampus - drug effects Hippocampus - enzymology Male Maze Learning - drug effects Medical sciences Memory Memory - drug effects Nervous system (semeiology, syndromes) Neurology Organic mental disorders. Neuropsychology Parasympatholytics - pharmacology Phytotherapy Prefrontal Cortex - drug effects Prefrontal Cortex - enzymology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Rats Rats, Sprague-Dawley Scopolamine Hydrobromide - antagonists & inhibitors Scopolamine Hydrobromide - pharmacology Turmeric
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