Adenoviral delivery of dominant-negative transforming growth factor β type II receptor up-regulates transcriptional repressor SKI-like oncogene, decreases matrix metalloproteinase 2 in hepatic stellate cell and prevents liver fibrosis in rats

Background Dominant‐negative transforming growth factor β type II receptor (TβRIIΔcyt) is a protein that blocks transforming growth factor (TGF‐β) signaling. Because the consequences of blocking TGF‐β have not been completely elucidated in liver fibrosis, we analysed the effects of adenoviral delive...

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Veröffentlicht in:	The journal of gene medicine 2009-03, Vol.11 (3), p.207-219
Hauptverfasser:	Marquez-Aguirre, Ana, Sandoval-Rodriguez, Ana, Gonzalez-Cuevas, Jaime, Bueno- Topete, Miriam, Navarro-Partida, Jose, Arellano-Olivera, Immaculada, Lucano-Landeros, Silvia, Armendariz-Borunda, Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviridae - metabolism Animals Body Weight Cells, Cultured Gene Transfer Techniques hepatic stellate cells Hepatic Stellate Cells - cytology Hepatic Stellate Cells - metabolism Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Liver Cirrhosis - chemically induced Liver Cirrhosis - pathology Liver Cirrhosis - prevention & control liver fibrosis Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 3 - genetics Matrix Metalloproteinase 3 - metabolism MMP-2 Oncogene Proteins - genetics Oncogene Proteins - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Rats Receptors, Transforming Growth Factor beta - genetics Receptors, Transforming Growth Factor beta - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Signal Transduction - physiology SnoN TGF-β signaling thioacetamide Thioacetamide - pharmacology Transduction, Genetic Transgenes Up-Regulation
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