A sensitive post-column photochemical derivatization/fluorimetric detection system for HPLC determination of bisphosphonates

A new reversed-phase ion-pair high-performance liquid chromatographic (HPLC) method has been developed for the determination of the following bisphosphonic acids: alendronic acid (ALEN), etidronic acid (ETID), ibandronic acid (IBAN) and risedronic acid (RISE). Separation was achieved on a C18 column...

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Veröffentlicht in:	Journal of Chromatography A 2009-02, Vol.1216 (9), p.1312-1318
Hauptverfasser:	Pérez-Ruiz, Tomás, Martínez-Lozano, Carmen, García-Martínez, María Dolores
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biological and medical sciences Bisphosphonates Bone Density Conservation Agents - analysis Bone Density Conservation Agents - isolation & purification Bone Density Conservation Agents - urine Calcium Chloride - chemistry Chromatography, High Pressure Liquid - methods Diphosphonates - analysis Diphosphonates - isolation & purification Diphosphonates - urine Equipment Design Fluorescence Fluorescence detection General pharmacology HPLC Humans Hydrogen-Ion Concentration Linear Models Medical sciences Molybdenum - chemistry Molybdophosphoric acid reaction On-line photo-oxidation Pharmaceuticals Pharmacology. Drug treatments Phosphoric Acids - chemistry Photochemistry - methods Quaternary Ammonium Compounds - chemistry Reproducibility of Results Sensitivity and Specificity Tablets - analysis Thiamine - analogs & derivatives Thiamine - analysis Thiamine - chemistry Urine
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