Tracheal instillation of diesel exhaust particles component causes blood and pulmonary neutrophilia and enhances myocardial oxidative stress in mice
The influences of inhaling particulate air-pollutants on hematopoiesis and myocardial oxidative stress were investigated in mice by intratracheal instillation (IT) of diesel exhaust particles (DEP), its dichloromethane soluble-component (DMSC) or residual particle-component (RPC). After IT, time cou...
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| Veröffentlicht in: | Journal of toxicological sciences 2008/12/01, Vol.33(5), pp.609-620 |
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| creator | Yokota, Syunji Seki, Takayuki Naito, Yukiko Tachibana, Shigehiro Hirabayashi, Naoyuki Nakasaka, Toshiaki Ohara, Naoki Kobayashi, Hiroyuki |
| description | The influences of inhaling particulate air-pollutants on hematopoiesis and myocardial oxidative stress were investigated in mice by intratracheal instillation (IT) of diesel exhaust particles (DEP), its dichloromethane soluble-component (DMSC) or residual particle-component (RPC). After IT, time courses of cytokine levels in bronchial alveolar lavage fluid (BALF), peripheral blood cell count, myocardial myeloperoxidase (MPO) activity and myocardial chemokine levels were observed for 24 hr. RPC caused sustained blood neutrophilia while that caused by DEP and DMSC was transient. RPC also caused sustained elevations of granulocyte colony-stimulating factor (G-CSF) and interleukin (IL)-6 levels in BALF. Furthermore, IL-1ß level in BALF in the RPC group was significantly elevated at 24 hr after IT. Significant positive correlations were observed between blood neutrophil count and IL-6/G-CSF levels in BALF. MPO activity in the myocardium was increased by RPC at 12 and 24 hr after IT while the activities in the kidney and the liver were not affected. Significant correlation was also observed between myocardial MPO activity and blood neutrophil count at 12 hr after IT, for all three substances. From these results, it was concluded that particle component of DEP may enhance myocardial oxidative stress via blood neutrophilia and the elevation of cytokine levels in BALF. |
| doi_str_mv | 10.2131/jts.33.609 |
| format | Article |
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After IT, time courses of cytokine levels in bronchial alveolar lavage fluid (BALF), peripheral blood cell count, myocardial myeloperoxidase (MPO) activity and myocardial chemokine levels were observed for 24 hr. RPC caused sustained blood neutrophilia while that caused by DEP and DMSC was transient. RPC also caused sustained elevations of granulocyte colony-stimulating factor (G-CSF) and interleukin (IL)-6 levels in BALF. Furthermore, IL-1ß level in BALF in the RPC group was significantly elevated at 24 hr after IT. Significant positive correlations were observed between blood neutrophil count and IL-6/G-CSF levels in BALF. MPO activity in the myocardium was increased by RPC at 12 and 24 hr after IT while the activities in the kidney and the liver were not affected. Significant correlation was also observed between myocardial MPO activity and blood neutrophil count at 12 hr after IT, for all three substances. From these results, it was concluded that particle component of DEP may enhance myocardial oxidative stress via blood neutrophilia and the elevation of cytokine levels in BALF.</description><identifier>ISSN: 0388-1350</identifier><identifier>EISSN: 1880-3989</identifier><identifier>DOI: 10.2131/jts.33.609</identifier><identifier>PMID: 19043282</identifier><language>eng</language><publisher>Japan: The Japanese Society of Toxicology</publisher><subject>Air pollutant ; Animals ; Bronchoalveolar Lavage Fluid - cytology ; Bronchoalveolar Lavage Fluid - immunology ; Cytokines - immunology ; Diesel exhaust particles ; Inhalation Exposure - adverse effects ; Kidney - drug effects ; Kidney - immunology ; Leukocyte Count ; Liver - drug effects ; Liver - immunology ; Male ; Mice ; Mice, Inbred Strains ; Myocardial myeloperoxidase ; Myocardium - enzymology ; Myocardium - immunology ; Myocardium - metabolism ; Neutrophil Infiltration - drug effects ; Neutrophil Infiltration - immunology ; Neutrophilia ; Neutrophils - cytology ; Neutrophils - drug effects ; Neutrophils - immunology ; Oxidative stress ; Oxidative Stress - drug effects ; Oxidative Stress - immunology ; Particulate Matter - toxicity ; Peroxidase - metabolism ; Pneumonia - blood ; Pneumonia - chemically induced ; Pneumonia - immunology ; Trachea - drug effects ; Vehicle Emissions - toxicity</subject><ispartof>The Journal of Toxicological Sciences, 2008/12/01, Vol.33(5), pp.609-620</ispartof><rights>2008 The Japanese Society of Toxicology</rights><rights>Copyright Japan Science and Technology Agency 2008</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c652t-781d5d536953446e2d2e48724d09ba144f4c3b8c7de871090e9d7fc7fc8758c93</citedby><cites>FETCH-LOGICAL-c652t-781d5d536953446e2d2e48724d09ba144f4c3b8c7de871090e9d7fc7fc8758c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19043282$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yokota, Syunji</creatorcontrib><creatorcontrib>Seki, Takayuki</creatorcontrib><creatorcontrib>Naito, Yukiko</creatorcontrib><creatorcontrib>Tachibana, Shigehiro</creatorcontrib><creatorcontrib>Hirabayashi, Naoyuki</creatorcontrib><creatorcontrib>Nakasaka, Toshiaki</creatorcontrib><creatorcontrib>Ohara, Naoki</creatorcontrib><creatorcontrib>Kobayashi, Hiroyuki</creatorcontrib><title>Tracheal instillation of diesel exhaust particles component causes blood and pulmonary neutrophilia and enhances myocardial oxidative stress in mice</title><title>Journal of toxicological sciences</title><addtitle>J Toxicol Sci</addtitle><description>The influences of inhaling particulate air-pollutants on hematopoiesis and myocardial oxidative stress were investigated in mice by intratracheal instillation (IT) of diesel exhaust particles (DEP), its dichloromethane soluble-component (DMSC) or residual particle-component (RPC). After IT, time courses of cytokine levels in bronchial alveolar lavage fluid (BALF), peripheral blood cell count, myocardial myeloperoxidase (MPO) activity and myocardial chemokine levels were observed for 24 hr. RPC caused sustained blood neutrophilia while that caused by DEP and DMSC was transient. RPC also caused sustained elevations of granulocyte colony-stimulating factor (G-CSF) and interleukin (IL)-6 levels in BALF. Furthermore, IL-1ß level in BALF in the RPC group was significantly elevated at 24 hr after IT. Significant positive correlations were observed between blood neutrophil count and IL-6/G-CSF levels in BALF. MPO activity in the myocardium was increased by RPC at 12 and 24 hr after IT while the activities in the kidney and the liver were not affected. Significant correlation was also observed between myocardial MPO activity and blood neutrophil count at 12 hr after IT, for all three substances. From these results, it was concluded that particle component of DEP may enhance myocardial oxidative stress via blood neutrophilia and the elevation of cytokine levels in BALF.</description><subject>Air pollutant</subject><subject>Animals</subject><subject>Bronchoalveolar Lavage Fluid - cytology</subject><subject>Bronchoalveolar Lavage Fluid - immunology</subject><subject>Cytokines - immunology</subject><subject>Diesel exhaust particles</subject><subject>Inhalation Exposure - adverse effects</subject><subject>Kidney - drug effects</subject><subject>Kidney - immunology</subject><subject>Leukocyte Count</subject><subject>Liver - drug effects</subject><subject>Liver - immunology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Myocardial myeloperoxidase</subject><subject>Myocardium - enzymology</subject><subject>Myocardium - immunology</subject><subject>Myocardium - metabolism</subject><subject>Neutrophil Infiltration - drug effects</subject><subject>Neutrophil Infiltration - immunology</subject><subject>Neutrophilia</subject><subject>Neutrophils - cytology</subject><subject>Neutrophils - drug effects</subject><subject>Neutrophils - immunology</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxidative Stress - immunology</subject><subject>Particulate Matter - toxicity</subject><subject>Peroxidase - metabolism</subject><subject>Pneumonia - blood</subject><subject>Pneumonia - chemically induced</subject><subject>Pneumonia - immunology</subject><subject>Trachea - drug effects</subject><subject>Vehicle Emissions - toxicity</subject><issn>0388-1350</issn><issn>1880-3989</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV9rFDEUxYModq2--AEkIPhQmG3-zmSeRIrVQsGX-hyyyR0ny0wyJpnSfg8_sGl3rVAICeT8OPdyDkLvKdkyyun5vuQt59uW9C_QhipFGt6r_iXaEK5UQ7kkJ-hNzntCWEekeI1OaE8EZ4pt0J-bZOwIZsI-5OKnyRQfA44Ddh4yTBjuRrPmgheTircTZGzjvMQAoWBblfqxm2J02ASHl3WaYzDpHgdYS4rL6CdvHiUIowm20vN9tCY5X0fGO-_qvFvAuSTIue6AZ2_hLXo1mCnDu-N7in5efr25-N5c__h2dfHlurGtZKXpFHXSSd72kgvRAnMMhOqYcKTfGSrEICzfKds5UB0lPYHedYOtR3VS2Z6fok8H3yXF3yvkomefLdQQAsQ1a1YD5KKVFfz4DNzHNYW6m6aiVUoJJh_szg6UTTHnBINekp9rGpoS_dCUrk1pznVtqsIfjpbrbgb3Hz1WU4HPB2Cfi_kFT8Cxh39e8nBVyyfFjiZpCPwvJ26pDw</recordid><startdate>20081201</startdate><enddate>20081201</enddate><creator>Yokota, Syunji</creator><creator>Seki, Takayuki</creator><creator>Naito, Yukiko</creator><creator>Tachibana, Shigehiro</creator><creator>Hirabayashi, Naoyuki</creator><creator>Nakasaka, Toshiaki</creator><creator>Ohara, Naoki</creator><creator>Kobayashi, Hiroyuki</creator><general>The Japanese Society of Toxicology</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7U7</scope><scope>C1K</scope><scope>SOI</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20081201</creationdate><title>Tracheal instillation of diesel exhaust particles component causes blood and pulmonary neutrophilia and enhances myocardial oxidative stress in mice</title><author>Yokota, Syunji ; Seki, Takayuki ; Naito, Yukiko ; Tachibana, Shigehiro ; Hirabayashi, Naoyuki ; Nakasaka, Toshiaki ; Ohara, Naoki ; Kobayashi, Hiroyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c652t-781d5d536953446e2d2e48724d09ba144f4c3b8c7de871090e9d7fc7fc8758c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Air pollutant</topic><topic>Animals</topic><topic>Bronchoalveolar Lavage Fluid - cytology</topic><topic>Bronchoalveolar Lavage Fluid - immunology</topic><topic>Cytokines - immunology</topic><topic>Diesel exhaust particles</topic><topic>Inhalation Exposure - adverse effects</topic><topic>Kidney - drug effects</topic><topic>Kidney - immunology</topic><topic>Leukocyte Count</topic><topic>Liver - drug effects</topic><topic>Liver - immunology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Myocardial myeloperoxidase</topic><topic>Myocardium - enzymology</topic><topic>Myocardium - immunology</topic><topic>Myocardium - metabolism</topic><topic>Neutrophil Infiltration - drug effects</topic><topic>Neutrophil Infiltration - immunology</topic><topic>Neutrophilia</topic><topic>Neutrophils - cytology</topic><topic>Neutrophils - drug effects</topic><topic>Neutrophils - immunology</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Oxidative Stress - immunology</topic><topic>Particulate Matter - toxicity</topic><topic>Peroxidase - metabolism</topic><topic>Pneumonia - blood</topic><topic>Pneumonia - chemically induced</topic><topic>Pneumonia - immunology</topic><topic>Trachea - drug effects</topic><topic>Vehicle Emissions - toxicity</topic><toplevel>online_resources</toplevel><creatorcontrib>Yokota, Syunji</creatorcontrib><creatorcontrib>Seki, Takayuki</creatorcontrib><creatorcontrib>Naito, Yukiko</creatorcontrib><creatorcontrib>Tachibana, Shigehiro</creatorcontrib><creatorcontrib>Hirabayashi, Naoyuki</creatorcontrib><creatorcontrib>Nakasaka, Toshiaki</creatorcontrib><creatorcontrib>Ohara, Naoki</creatorcontrib><creatorcontrib>Kobayashi, Hiroyuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of toxicological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yokota, Syunji</au><au>Seki, Takayuki</au><au>Naito, Yukiko</au><au>Tachibana, Shigehiro</au><au>Hirabayashi, Naoyuki</au><au>Nakasaka, Toshiaki</au><au>Ohara, Naoki</au><au>Kobayashi, Hiroyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tracheal instillation of diesel exhaust particles component causes blood and pulmonary neutrophilia and enhances myocardial oxidative stress in mice</atitle><jtitle>Journal of toxicological sciences</jtitle><addtitle>J Toxicol Sci</addtitle><date>2008-12-01</date><risdate>2008</risdate><volume>33</volume><issue>5</issue><spage>609</spage><epage>620</epage><pages>609-620</pages><issn>0388-1350</issn><eissn>1880-3989</eissn><abstract>The influences of inhaling particulate air-pollutants on hematopoiesis and myocardial oxidative stress were investigated in mice by intratracheal instillation (IT) of diesel exhaust particles (DEP), its dichloromethane soluble-component (DMSC) or residual particle-component (RPC). After IT, time courses of cytokine levels in bronchial alveolar lavage fluid (BALF), peripheral blood cell count, myocardial myeloperoxidase (MPO) activity and myocardial chemokine levels were observed for 24 hr. RPC caused sustained blood neutrophilia while that caused by DEP and DMSC was transient. RPC also caused sustained elevations of granulocyte colony-stimulating factor (G-CSF) and interleukin (IL)-6 levels in BALF. Furthermore, IL-1ß level in BALF in the RPC group was significantly elevated at 24 hr after IT. Significant positive correlations were observed between blood neutrophil count and IL-6/G-CSF levels in BALF. MPO activity in the myocardium was increased by RPC at 12 and 24 hr after IT while the activities in the kidney and the liver were not affected. Significant correlation was also observed between myocardial MPO activity and blood neutrophil count at 12 hr after IT, for all three substances. From these results, it was concluded that particle component of DEP may enhance myocardial oxidative stress via blood neutrophilia and the elevation of cytokine levels in BALF.</abstract><cop>Japan</cop><pub>The Japanese Society of Toxicology</pub><pmid>19043282</pmid><doi>10.2131/jts.33.609</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Air pollutant Animals Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology Cytokines - immunology Diesel exhaust particles Inhalation Exposure - adverse effects Kidney - drug effects Kidney - immunology Leukocyte Count Liver - drug effects Liver - immunology Male Mice Mice, Inbred Strains Myocardial myeloperoxidase Myocardium - enzymology Myocardium - immunology Myocardium - metabolism Neutrophil Infiltration - drug effects Neutrophil Infiltration - immunology Neutrophilia Neutrophils - cytology Neutrophils - drug effects Neutrophils - immunology Oxidative stress Oxidative Stress - drug effects Oxidative Stress - immunology Particulate Matter - toxicity Peroxidase - metabolism Pneumonia - blood Pneumonia - chemically induced Pneumonia - immunology Trachea - drug effects Vehicle Emissions - toxicity |
| title | Tracheal instillation of diesel exhaust particles component causes blood and pulmonary neutrophilia and enhances myocardial oxidative stress in mice |
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