Targeting cancer metabolism to develop human lactate dehydrogenase (hLDH)5 inhibitors

[Display omitted] •Development of hLDH5 inhibitors targeting cancer metabolism is described.•Structural information of hLDH5 is summarized for rational anticancer drug design.•Targeting the adenosine and pyruvate/nicotinamide binding pocket is the most promising strategy for the development of hLDH5...

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Veröffentlicht in:	Drug discovery today 2018-07, Vol.23 (7), p.1407-1415
Hauptverfasser:	Zhang, Shao-Lin, He, Yun, Tam, Kin Yip
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Drug Discovery - methods Energy Metabolism - drug effects Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Humans Isoenzymes - antagonists & inhibitors Isoenzymes - chemistry Isoenzymes - metabolism L-Lactate Dehydrogenase - antagonists & inhibitors L-Lactate Dehydrogenase - chemistry L-Lactate Dehydrogenase - metabolism Models, Molecular Molecular Targeted Therapy Neoplasms - drug therapy Neoplasms - enzymology Neoplasms - pathology Protein Conformation Structure-Activity Relationship
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