Sex-related differences in the associations between maternal dioxin-like compounds and reproductive and steroid hormones in cord blood: The Hokkaido study
Prenatal exposure to dioxin-like compounds (DLCs) irreversibly affects fetal reproductive and steroid hormone synthesis. This study aimed to assess the relationships between maternal DLCs and cord blood reproductive and steroid hormones. Participants in this study were pregnant women who enrolled in...
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| Veröffentlicht in: | Environment international 2018-08, Vol.117, p.175-185 |
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| creator | Miyashita, Chihiro Araki, Atsuko Mitsui, Takahiko Itoh, Sachiko Goudarzi, Houman Sasaki, Seiko Kajiwara, Jumboku Hori, Tsuguhide Cho, Kazutoshi Moriya, Kimihiko Shinohara, Nobuo Nonomura, Katsuya Kishi, Reiko |
| description | Prenatal exposure to dioxin-like compounds (DLCs) irreversibly affects fetal reproductive and steroid hormone synthesis.
This study aimed to assess the relationships between maternal DLCs and cord blood reproductive and steroid hormones.
Participants in this study were pregnant women who enrolled in the Sapporo Cohort of the Hokkaido Study between 2002 and 2005. We quantified 29 DLCs during the 2nd and 3rd trimesters in maternal blood. Additionally, we measured the concentrations of progesterone, estradiol (E2), testosterone (T), androstenedione, dehydroepiandrosterone (DHEA), cortisol, cortisone, sex hormone-binding globulin (SHBG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, inhibin B, and insulin-like factor-3 (INSL3) in cord blood samples.
Data from 183 mother-child pairs were analyzed. We observed sex-dependent associations of DLCs on T/E2 ratios, DHEA, cortisol, cortisone, adrenal androgen/glucocorticoid (AA/GC: sum of DHEA and androstenedione)/(sum of cortisol and cortisone) ratios and SHBG. An increase in maternal DLCs related to decreased T/E2 ratios and SHBG and inhibin B levels, and increased AA/GC ratios and FSH and DHEA levels in male cord blood samples. However, an increase in maternal mono-ortho polychlorinated biphenyls related to increased cortisol, cortisone, and SHBG levels, and decreased DHEA levels and AA/GC ratios in female cord blood samples.
Prenatal exposure to DLCs alters steroidogenesis and suppresses the secretion of inhibin B in male cord blood. Relationships between maternal DLCs and cord blood hormones differ between boys and girls. Further studies are required to clarify whether the effects of in utero exposure to DLCs on adrenal hormones extend into infancy and puberty.
[Display omitted]
•We quantified maternal DLCs and reproductive/steroid hormones in the cord blood.•DLCs directly correlated with DHEA and AA/GC ratio in male cord blood.•DLCs inversely correlate with T/E2 ratio and inhibin B in male cord blood samples.•In utero DLC exposure negatively affects the offspring. |
| doi_str_mv | 10.1016/j.envint.2018.04.046 |
| format | Article |
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This study aimed to assess the relationships between maternal DLCs and cord blood reproductive and steroid hormones.
Participants in this study were pregnant women who enrolled in the Sapporo Cohort of the Hokkaido Study between 2002 and 2005. We quantified 29 DLCs during the 2nd and 3rd trimesters in maternal blood. Additionally, we measured the concentrations of progesterone, estradiol (E2), testosterone (T), androstenedione, dehydroepiandrosterone (DHEA), cortisol, cortisone, sex hormone-binding globulin (SHBG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, inhibin B, and insulin-like factor-3 (INSL3) in cord blood samples.
Data from 183 mother-child pairs were analyzed. We observed sex-dependent associations of DLCs on T/E2 ratios, DHEA, cortisol, cortisone, adrenal androgen/glucocorticoid (AA/GC: sum of DHEA and androstenedione)/(sum of cortisol and cortisone) ratios and SHBG. An increase in maternal DLCs related to decreased T/E2 ratios and SHBG and inhibin B levels, and increased AA/GC ratios and FSH and DHEA levels in male cord blood samples. However, an increase in maternal mono-ortho polychlorinated biphenyls related to increased cortisol, cortisone, and SHBG levels, and decreased DHEA levels and AA/GC ratios in female cord blood samples.
Prenatal exposure to DLCs alters steroidogenesis and suppresses the secretion of inhibin B in male cord blood. Relationships between maternal DLCs and cord blood hormones differ between boys and girls. Further studies are required to clarify whether the effects of in utero exposure to DLCs on adrenal hormones extend into infancy and puberty.
[Display omitted]
•We quantified maternal DLCs and reproductive/steroid hormones in the cord blood.•DLCs directly correlated with DHEA and AA/GC ratio in male cord blood.•DLCs inversely correlate with T/E2 ratio and inhibin B in male cord blood samples.•In utero DLC exposure negatively affects the offspring.</description><identifier>ISSN: 0160-4120</identifier><identifier>EISSN: 1873-6750</identifier><identifier>DOI: 10.1016/j.envint.2018.04.046</identifier><identifier>PMID: 29753148</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adult ; Cohort Studies ; Cord blood ; Dioxin-like compounds ; Dioxins - blood ; Female ; Fetal Blood - chemistry ; Hormones - blood ; Humans ; Infant, Newborn ; Pregnancy ; Prenatal exposure ; Reproductive hormones</subject><ispartof>Environment international, 2018-08, Vol.117, p.175-185</ispartof><rights>2018 Elsevier Ltd</rights><rights>Copyright © 2018 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-ae5308ba0702a00220caec7eec4dd24b321e87dab9c5689572c9a3b8b007854d3</citedby><cites>FETCH-LOGICAL-c518t-ae5308ba0702a00220caec7eec4dd24b321e87dab9c5689572c9a3b8b007854d3</cites><orcidid>0000-0003-0996-3631 ; 0000-0002-3065-262X ; 0000-0003-2742-4084 ; 0000-0001-8173-9269 ; 0000-0001-6161-9403</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.envint.2018.04.046$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29753148$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyashita, Chihiro</creatorcontrib><creatorcontrib>Araki, Atsuko</creatorcontrib><creatorcontrib>Mitsui, Takahiko</creatorcontrib><creatorcontrib>Itoh, Sachiko</creatorcontrib><creatorcontrib>Goudarzi, Houman</creatorcontrib><creatorcontrib>Sasaki, Seiko</creatorcontrib><creatorcontrib>Kajiwara, Jumboku</creatorcontrib><creatorcontrib>Hori, Tsuguhide</creatorcontrib><creatorcontrib>Cho, Kazutoshi</creatorcontrib><creatorcontrib>Moriya, Kimihiko</creatorcontrib><creatorcontrib>Shinohara, Nobuo</creatorcontrib><creatorcontrib>Nonomura, Katsuya</creatorcontrib><creatorcontrib>Kishi, Reiko</creatorcontrib><title>Sex-related differences in the associations between maternal dioxin-like compounds and reproductive and steroid hormones in cord blood: The Hokkaido study</title><title>Environment international</title><addtitle>Environ Int</addtitle><description>Prenatal exposure to dioxin-like compounds (DLCs) irreversibly affects fetal reproductive and steroid hormone synthesis.
This study aimed to assess the relationships between maternal DLCs and cord blood reproductive and steroid hormones.
Participants in this study were pregnant women who enrolled in the Sapporo Cohort of the Hokkaido Study between 2002 and 2005. We quantified 29 DLCs during the 2nd and 3rd trimesters in maternal blood. Additionally, we measured the concentrations of progesterone, estradiol (E2), testosterone (T), androstenedione, dehydroepiandrosterone (DHEA), cortisol, cortisone, sex hormone-binding globulin (SHBG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, inhibin B, and insulin-like factor-3 (INSL3) in cord blood samples.
Data from 183 mother-child pairs were analyzed. We observed sex-dependent associations of DLCs on T/E2 ratios, DHEA, cortisol, cortisone, adrenal androgen/glucocorticoid (AA/GC: sum of DHEA and androstenedione)/(sum of cortisol and cortisone) ratios and SHBG. An increase in maternal DLCs related to decreased T/E2 ratios and SHBG and inhibin B levels, and increased AA/GC ratios and FSH and DHEA levels in male cord blood samples. However, an increase in maternal mono-ortho polychlorinated biphenyls related to increased cortisol, cortisone, and SHBG levels, and decreased DHEA levels and AA/GC ratios in female cord blood samples.
Prenatal exposure to DLCs alters steroidogenesis and suppresses the secretion of inhibin B in male cord blood. Relationships between maternal DLCs and cord blood hormones differ between boys and girls. Further studies are required to clarify whether the effects of in utero exposure to DLCs on adrenal hormones extend into infancy and puberty.
[Display omitted]
•We quantified maternal DLCs and reproductive/steroid hormones in the cord blood.•DLCs directly correlated with DHEA and AA/GC ratio in male cord blood.•DLCs inversely correlate with T/E2 ratio and inhibin B in male cord blood samples.•In utero DLC exposure negatively affects the offspring.</description><subject>Adult</subject><subject>Cohort Studies</subject><subject>Cord blood</subject><subject>Dioxin-like compounds</subject><subject>Dioxins - blood</subject><subject>Female</subject><subject>Fetal Blood - chemistry</subject><subject>Hormones - blood</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Pregnancy</subject><subject>Prenatal exposure</subject><subject>Reproductive hormones</subject><issn>0160-4120</issn><issn>1873-6750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kdFqFDEUhoModq2-gUguvZn1JJNMsl4IUtQWCl5Yr0MmOUuzO5Osycy2fRWf1myneikcCITvz5_DR8hbBmsGrPuwW2M8hjitOTC9BlGne0ZWTKu26ZSE52RVMWgE43BGXpWyAwAutHxJzvhGyZYJvSK_f-B9k3GwE3rqw3aLGaPDQkOk0y1SW0pywU4hxUJ7nO4QIx0rnaMdaiDdh9gMYY_UpfGQ5ugLtdHTjIec_OymcMTHi1IjKXh6m_KY4lLgUva0H1LyH-lNLbtM-70NPlV49g-vyYutHQq-eTrPyc-vX24uLpvr79-uLj5fN04yPTUWZQu6t6CA27ohB2fRKUQnvOeibzlDrbztN052eiMVdxvb9roHUFoK356T98u79ce_ZiyTGUNxOAw2YpqL4dBqrriUrKJiQV1OpWTcmkMOo80PhoE5WTE7s1gxJysGRJ2uxt49Ncz9iP5f6K-GCnxaAKx7HgNmU1w4efAho5uMT-H_DX8ALlCjyw</recordid><startdate>201808</startdate><enddate>201808</enddate><creator>Miyashita, Chihiro</creator><creator>Araki, Atsuko</creator><creator>Mitsui, Takahiko</creator><creator>Itoh, Sachiko</creator><creator>Goudarzi, Houman</creator><creator>Sasaki, Seiko</creator><creator>Kajiwara, Jumboku</creator><creator>Hori, Tsuguhide</creator><creator>Cho, Kazutoshi</creator><creator>Moriya, Kimihiko</creator><creator>Shinohara, Nobuo</creator><creator>Nonomura, Katsuya</creator><creator>Kishi, Reiko</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0996-3631</orcidid><orcidid>https://orcid.org/0000-0002-3065-262X</orcidid><orcidid>https://orcid.org/0000-0003-2742-4084</orcidid><orcidid>https://orcid.org/0000-0001-8173-9269</orcidid><orcidid>https://orcid.org/0000-0001-6161-9403</orcidid></search><sort><creationdate>201808</creationdate><title>Sex-related differences in the associations between maternal dioxin-like compounds and reproductive and steroid hormones in cord blood: The Hokkaido study</title><author>Miyashita, Chihiro ; 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This study aimed to assess the relationships between maternal DLCs and cord blood reproductive and steroid hormones.
Participants in this study were pregnant women who enrolled in the Sapporo Cohort of the Hokkaido Study between 2002 and 2005. We quantified 29 DLCs during the 2nd and 3rd trimesters in maternal blood. Additionally, we measured the concentrations of progesterone, estradiol (E2), testosterone (T), androstenedione, dehydroepiandrosterone (DHEA), cortisol, cortisone, sex hormone-binding globulin (SHBG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, inhibin B, and insulin-like factor-3 (INSL3) in cord blood samples.
Data from 183 mother-child pairs were analyzed. We observed sex-dependent associations of DLCs on T/E2 ratios, DHEA, cortisol, cortisone, adrenal androgen/glucocorticoid (AA/GC: sum of DHEA and androstenedione)/(sum of cortisol and cortisone) ratios and SHBG. An increase in maternal DLCs related to decreased T/E2 ratios and SHBG and inhibin B levels, and increased AA/GC ratios and FSH and DHEA levels in male cord blood samples. However, an increase in maternal mono-ortho polychlorinated biphenyls related to increased cortisol, cortisone, and SHBG levels, and decreased DHEA levels and AA/GC ratios in female cord blood samples.
Prenatal exposure to DLCs alters steroidogenesis and suppresses the secretion of inhibin B in male cord blood. Relationships between maternal DLCs and cord blood hormones differ between boys and girls. Further studies are required to clarify whether the effects of in utero exposure to DLCs on adrenal hormones extend into infancy and puberty.
[Display omitted]
•We quantified maternal DLCs and reproductive/steroid hormones in the cord blood.•DLCs directly correlated with DHEA and AA/GC ratio in male cord blood.•DLCs inversely correlate with T/E2 ratio and inhibin B in male cord blood samples.•In utero DLC exposure negatively affects the offspring.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>29753148</pmid><doi>10.1016/j.envint.2018.04.046</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-0996-3631</orcidid><orcidid>https://orcid.org/0000-0002-3065-262X</orcidid><orcidid>https://orcid.org/0000-0003-2742-4084</orcidid><orcidid>https://orcid.org/0000-0001-8173-9269</orcidid><orcidid>https://orcid.org/0000-0001-6161-9403</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Environment international, 2018-08, Vol.117, p.175-185 |
| issn | 0160-4120 1873-6750 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Cohort Studies Cord blood Dioxin-like compounds Dioxins - blood Female Fetal Blood - chemistry Hormones - blood Humans Infant, Newborn Pregnancy Prenatal exposure Reproductive hormones |
| title | Sex-related differences in the associations between maternal dioxin-like compounds and reproductive and steroid hormones in cord blood: The Hokkaido study |
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