IFNAR1 Controls Autocrine Type I IFN Regulation of PD-L1 Expression in Myeloid-Derived Suppressor Cells

Tumor cells respond to IFN-γ of activated T cells to upregulate programmed death-ligand 1 (PD-L1) in the tumor microenvironment as an adaptive immune resistance mechanism. Tumor cells also express oncogene-driven PD-L1. PD-L1 is also expressed on myeloid-derived suppressor cells (MDSCs). It is known...

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Veröffentlicht in:	The Journal of immunology (1950) 2018-07, Vol.201 (1), p.264-277
Hauptverfasser:	Xiao, Wei, Klement, John D, Lu, Chunwan, Ibrahim, Mohammed L, Liu, Kebin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Autocrine signalling B7-H1 Antigen - biosynthesis Cell Line, Tumor Female Interferon-alpha - biosynthesis Interferon-beta - biosynthesis Interferon-gamma - biosynthesis Kinases Lymphocytes Lymphocytes T Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Molecular chains Myeloid-Derived Suppressor Cells - metabolism Neoplasms - genetics Neoplasms - immunology PD-L1 protein Phosphorylation Receptor, Interferon alpha-beta - genetics Receptor, Interferon alpha-beta - metabolism Signal transduction Stat1 protein STAT1 Transcription Factor - metabolism Suppressor cells Tumor cells Tumor Microenvironment - physiology α-Interferon β-Interferon γ-Interferon
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