Body composition, fatigue and exercise in patients with prostate cancer undergoing androgen‐deprivation therapy
Objectives To investigate the association between lean mass (LM) and fat mass (FM) with fatigue and vitality before and after exercise in patients with prostate cancer already undergoing androgen‐deprivation therapy (ADT). Subjects and Methods Cross‐sectional associations between LM and FM with fati...
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| Veröffentlicht in: | BJU international 2018-12, Vol.122 (6), p.986-993 |
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| creator | Newton, Robert U. Jeffery, Emily Galvão, Daniel A. Peddle‐McIntyre, Carolyn J. Spry, Nigel Joseph, David Denham, James W. Taaffe, Dennis R. |
| description | Objectives
To investigate the association between lean mass (LM) and fat mass (FM) with fatigue and vitality before and after exercise in patients with prostate cancer already undergoing androgen‐deprivation therapy (ADT).
Subjects and Methods
Cross‐sectional associations between LM and FM with fatigue and/or vitality measures were examined in 229 patients (aged 43–90 years). Prospective analysis was undertaken in 129 patients who underwent a supervised 3–6 months exercise programme (predominantly resistance + aerobic). Whole body and appendicular LM, and total and trunk FM were assessed by dual X‐ray absorptiometry. Fatigue was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire‐Core 30 (EORTC QLQ‐30) and vitality using the Short Form‐36.
Results
Based on the EORTC QLQ‐30, 19% of patients had clinically relevant fatigue. There was no association between LM and fatigue; however, total (P = 0.013), trunk (P = 0.015) and percentage (P = 0.008) FM were higher in fatigued than not fatigued patients, with total and trunk FM 5.0 and 2.6 kg higher, respectively. For quartiles of vitality, a similar pattern emerged for FM with those in the lowest quartile of vitality having the highest FM values (P = 0.014–0.034). In contrast, following supervised exercise, change in fatigue and vitality were associated with change in total LM (r = −0.182, P = 0.042 and r = 0.309, P = 0.001, respectively) but not FM. Patients fatigued at baseline but not fatigued following the exercise programme gained a median (interquartile range) of 2.1 (0.7–3.2) kg LM.
Conclusion
In patients with prostate cancer treated with ADT, body composition is associated with fatigue, with higher total and trunk FM in those with clinically relevant fatigue. However, following exercise those no longer fatigued had an accompanying substantial increase in LM. Modifying body composition, both LM and FM, in patients with prostate cancer may favourably alter cancer‐related fatigue levels and should be a target of exercise medicine in this population. |
| doi_str_mv | 10.1111/bju.14384 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2038270610</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2038270610</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3884-7d790eaf25667c941614bf1a9e373bb8e5f0e142e8982a8e4376c5eb0bbab1163</originalsourceid><addsrcrecordid>eNp1kUtOHDEQhi2UKLyyyAUiS9mAlAG_2u1eAiJAhMQGJHaW7a4ePJqxG7sbMrscgTPmJHgywAIJb2yVPn-qqh-hb5Qc0HIO7Ww8oIIrsYG2qJBiIii5_fT6Jo3cRNs5zwgpBVl9QZusqSvCG7WF7o9ju8QuLvqY_eBj-Ik7M_jpCNiEFsMfSM5nwD7gvtQhDBk_-uEO9ynmwQyAnQkOEh5DC2kafZiuPqY4hfDv71MLffIPZiXGwx0k0y930efOzDN8fbl30M2v0-uT88nl1dnFydHlxHGlxKRu64aA6VglZe0aQSUVtqOmAV5zaxVUHQEqGKhGMaNA8Fq6Ciyx1lhKJd9Be2tv6fR-hDzohc8O5nMTII5ZM8IVq4mkpKA_3qGzOKZQutOM8kqxhjBVqP015croOUGny2wLk5aaEr3KQZcc9P8cCvv9xTjaBbRv5OviC3C4Bh79HJYfm_Tx75u18hnvaZQ-</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2135829028</pqid></control><display><type>article</type><title>Body composition, fatigue and exercise in patients with prostate cancer undergoing androgen‐deprivation therapy</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Newton, Robert U. ; Jeffery, Emily ; Galvão, Daniel A. ; Peddle‐McIntyre, Carolyn J. ; Spry, Nigel ; Joseph, David ; Denham, James W. ; Taaffe, Dennis R.</creator><creatorcontrib>Newton, Robert U. ; Jeffery, Emily ; Galvão, Daniel A. ; Peddle‐McIntyre, Carolyn J. ; Spry, Nigel ; Joseph, David ; Denham, James W. ; Taaffe, Dennis R.</creatorcontrib><description>Objectives
To investigate the association between lean mass (LM) and fat mass (FM) with fatigue and vitality before and after exercise in patients with prostate cancer already undergoing androgen‐deprivation therapy (ADT).
Subjects and Methods
Cross‐sectional associations between LM and FM with fatigue and/or vitality measures were examined in 229 patients (aged 43–90 years). Prospective analysis was undertaken in 129 patients who underwent a supervised 3–6 months exercise programme (predominantly resistance + aerobic). Whole body and appendicular LM, and total and trunk FM were assessed by dual X‐ray absorptiometry. Fatigue was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire‐Core 30 (EORTC QLQ‐30) and vitality using the Short Form‐36.
Results
Based on the EORTC QLQ‐30, 19% of patients had clinically relevant fatigue. There was no association between LM and fatigue; however, total (P = 0.013), trunk (P = 0.015) and percentage (P = 0.008) FM were higher in fatigued than not fatigued patients, with total and trunk FM 5.0 and 2.6 kg higher, respectively. For quartiles of vitality, a similar pattern emerged for FM with those in the lowest quartile of vitality having the highest FM values (P = 0.014–0.034). In contrast, following supervised exercise, change in fatigue and vitality were associated with change in total LM (r = −0.182, P = 0.042 and r = 0.309, P = 0.001, respectively) but not FM. Patients fatigued at baseline but not fatigued following the exercise programme gained a median (interquartile range) of 2.1 (0.7–3.2) kg LM.
Conclusion
In patients with prostate cancer treated with ADT, body composition is associated with fatigue, with higher total and trunk FM in those with clinically relevant fatigue. However, following exercise those no longer fatigued had an accompanying substantial increase in LM. Modifying body composition, both LM and FM, in patients with prostate cancer may favourably alter cancer‐related fatigue levels and should be a target of exercise medicine in this population.</description><identifier>ISSN: 1464-4096</identifier><identifier>EISSN: 1464-410X</identifier><identifier>DOI: 10.1111/bju.14384</identifier><identifier>PMID: 29750398</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Absorptiometry ; Adult ; Aged ; Aged, 80 and over ; Androgen Antagonists - adverse effects ; Androgen Antagonists - therapeutic use ; Androgens ; androgen‐deprivation therapy ; Antineoplastic Agents, Hormonal - adverse effects ; Antineoplastic Agents, Hormonal - therapeutic use ; Body composition ; Body Composition - drug effects ; Body fat ; Cross-Sectional Studies ; Exercise ; Exercise Therapy ; Exercise Tolerance - physiology ; Fatigue ; Fatigue - chemically induced ; Fatigue - physiopathology ; Fatigue - rehabilitation ; Humans ; Male ; Middle Aged ; Muscle Strength - drug effects ; Muscle, Skeletal - drug effects ; Patients ; PCSM ; Prospective Studies ; Prostate cancer ; ProstateCancer ; Prostatic Neoplasms - drug therapy ; Prostatic Neoplasms - physiopathology ; Prostatic Neoplasms - rehabilitation ; Quality of life ; Resistance Training ; Treatment Outcome</subject><ispartof>BJU international, 2018-12, Vol.122 (6), p.986-993</ispartof><rights>2018 The Authors BJU International © 2018 BJU International Published by John Wiley & Sons Ltd</rights><rights>2018 The Authors BJU International © 2018 BJU International Published by John Wiley & Sons Ltd.</rights><rights>BJUI © 2018 BJU International</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3884-7d790eaf25667c941614bf1a9e373bb8e5f0e142e8982a8e4376c5eb0bbab1163</citedby><cites>FETCH-LOGICAL-c3884-7d790eaf25667c941614bf1a9e373bb8e5f0e142e8982a8e4376c5eb0bbab1163</cites><orcidid>0000-0002-9463-3196 ; 0000-0001-6381-1597 ; 0000-0003-0302-6129 ; 0000-0001-9913-4022 ; 0000-0001-8659-5065</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbju.14384$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbju.14384$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27933,27934,45583,45584</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29750398$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Newton, Robert U.</creatorcontrib><creatorcontrib>Jeffery, Emily</creatorcontrib><creatorcontrib>Galvão, Daniel A.</creatorcontrib><creatorcontrib>Peddle‐McIntyre, Carolyn J.</creatorcontrib><creatorcontrib>Spry, Nigel</creatorcontrib><creatorcontrib>Joseph, David</creatorcontrib><creatorcontrib>Denham, James W.</creatorcontrib><creatorcontrib>Taaffe, Dennis R.</creatorcontrib><title>Body composition, fatigue and exercise in patients with prostate cancer undergoing androgen‐deprivation therapy</title><title>BJU international</title><addtitle>BJU Int</addtitle><description>Objectives
To investigate the association between lean mass (LM) and fat mass (FM) with fatigue and vitality before and after exercise in patients with prostate cancer already undergoing androgen‐deprivation therapy (ADT).
Subjects and Methods
Cross‐sectional associations between LM and FM with fatigue and/or vitality measures were examined in 229 patients (aged 43–90 years). Prospective analysis was undertaken in 129 patients who underwent a supervised 3–6 months exercise programme (predominantly resistance + aerobic). Whole body and appendicular LM, and total and trunk FM were assessed by dual X‐ray absorptiometry. Fatigue was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire‐Core 30 (EORTC QLQ‐30) and vitality using the Short Form‐36.
Results
Based on the EORTC QLQ‐30, 19% of patients had clinically relevant fatigue. There was no association between LM and fatigue; however, total (P = 0.013), trunk (P = 0.015) and percentage (P = 0.008) FM were higher in fatigued than not fatigued patients, with total and trunk FM 5.0 and 2.6 kg higher, respectively. For quartiles of vitality, a similar pattern emerged for FM with those in the lowest quartile of vitality having the highest FM values (P = 0.014–0.034). In contrast, following supervised exercise, change in fatigue and vitality were associated with change in total LM (r = −0.182, P = 0.042 and r = 0.309, P = 0.001, respectively) but not FM. Patients fatigued at baseline but not fatigued following the exercise programme gained a median (interquartile range) of 2.1 (0.7–3.2) kg LM.
Conclusion
In patients with prostate cancer treated with ADT, body composition is associated with fatigue, with higher total and trunk FM in those with clinically relevant fatigue. However, following exercise those no longer fatigued had an accompanying substantial increase in LM. Modifying body composition, both LM and FM, in patients with prostate cancer may favourably alter cancer‐related fatigue levels and should be a target of exercise medicine in this population.</description><subject>Absorptiometry</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Androgen Antagonists - adverse effects</subject><subject>Androgen Antagonists - therapeutic use</subject><subject>Androgens</subject><subject>androgen‐deprivation therapy</subject><subject>Antineoplastic Agents, Hormonal - adverse effects</subject><subject>Antineoplastic Agents, Hormonal - therapeutic use</subject><subject>Body composition</subject><subject>Body Composition - drug effects</subject><subject>Body fat</subject><subject>Cross-Sectional Studies</subject><subject>Exercise</subject><subject>Exercise Therapy</subject><subject>Exercise Tolerance - physiology</subject><subject>Fatigue</subject><subject>Fatigue - chemically induced</subject><subject>Fatigue - physiopathology</subject><subject>Fatigue - rehabilitation</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle Strength - drug effects</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Patients</subject><subject>PCSM</subject><subject>Prospective Studies</subject><subject>Prostate cancer</subject><subject>ProstateCancer</subject><subject>Prostatic Neoplasms - drug therapy</subject><subject>Prostatic Neoplasms - physiopathology</subject><subject>Prostatic Neoplasms - rehabilitation</subject><subject>Quality of life</subject><subject>Resistance Training</subject><subject>Treatment Outcome</subject><issn>1464-4096</issn><issn>1464-410X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtOHDEQhi2UKLyyyAUiS9mAlAG_2u1eAiJAhMQGJHaW7a4ePJqxG7sbMrscgTPmJHgywAIJb2yVPn-qqh-hb5Qc0HIO7Ww8oIIrsYG2qJBiIii5_fT6Jo3cRNs5zwgpBVl9QZusqSvCG7WF7o9ju8QuLvqY_eBj-Ik7M_jpCNiEFsMfSM5nwD7gvtQhDBk_-uEO9ynmwQyAnQkOEh5DC2kafZiuPqY4hfDv71MLffIPZiXGwx0k0y930efOzDN8fbl30M2v0-uT88nl1dnFydHlxHGlxKRu64aA6VglZe0aQSUVtqOmAV5zaxVUHQEqGKhGMaNA8Fq6Ciyx1lhKJd9Be2tv6fR-hDzohc8O5nMTII5ZM8IVq4mkpKA_3qGzOKZQutOM8kqxhjBVqP015croOUGny2wLk5aaEr3KQZcc9P8cCvv9xTjaBbRv5OviC3C4Bh79HJYfm_Tx75u18hnvaZQ-</recordid><startdate>201812</startdate><enddate>201812</enddate><creator>Newton, Robert U.</creator><creator>Jeffery, Emily</creator><creator>Galvão, Daniel A.</creator><creator>Peddle‐McIntyre, Carolyn J.</creator><creator>Spry, Nigel</creator><creator>Joseph, David</creator><creator>Denham, James W.</creator><creator>Taaffe, Dennis R.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9463-3196</orcidid><orcidid>https://orcid.org/0000-0001-6381-1597</orcidid><orcidid>https://orcid.org/0000-0003-0302-6129</orcidid><orcidid>https://orcid.org/0000-0001-9913-4022</orcidid><orcidid>https://orcid.org/0000-0001-8659-5065</orcidid></search><sort><creationdate>201812</creationdate><title>Body composition, fatigue and exercise in patients with prostate cancer undergoing androgen‐deprivation therapy</title><author>Newton, Robert U. ; Jeffery, Emily ; Galvão, Daniel A. ; Peddle‐McIntyre, Carolyn J. ; Spry, Nigel ; Joseph, David ; Denham, James W. ; Taaffe, Dennis R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3884-7d790eaf25667c941614bf1a9e373bb8e5f0e142e8982a8e4376c5eb0bbab1163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Absorptiometry</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Androgen Antagonists - adverse effects</topic><topic>Androgen Antagonists - therapeutic use</topic><topic>Androgens</topic><topic>androgen‐deprivation therapy</topic><topic>Antineoplastic Agents, Hormonal - adverse effects</topic><topic>Antineoplastic Agents, Hormonal - therapeutic use</topic><topic>Body composition</topic><topic>Body Composition - drug effects</topic><topic>Body fat</topic><topic>Cross-Sectional Studies</topic><topic>Exercise</topic><topic>Exercise Therapy</topic><topic>Exercise Tolerance - physiology</topic><topic>Fatigue</topic><topic>Fatigue - chemically induced</topic><topic>Fatigue - physiopathology</topic><topic>Fatigue - rehabilitation</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle Strength - drug effects</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Patients</topic><topic>PCSM</topic><topic>Prospective Studies</topic><topic>Prostate cancer</topic><topic>ProstateCancer</topic><topic>Prostatic Neoplasms - drug therapy</topic><topic>Prostatic Neoplasms - physiopathology</topic><topic>Prostatic Neoplasms - rehabilitation</topic><topic>Quality of life</topic><topic>Resistance Training</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Newton, Robert U.</creatorcontrib><creatorcontrib>Jeffery, Emily</creatorcontrib><creatorcontrib>Galvão, Daniel A.</creatorcontrib><creatorcontrib>Peddle‐McIntyre, Carolyn J.</creatorcontrib><creatorcontrib>Spry, Nigel</creatorcontrib><creatorcontrib>Joseph, David</creatorcontrib><creatorcontrib>Denham, James W.</creatorcontrib><creatorcontrib>Taaffe, Dennis R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>BJU international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Newton, Robert U.</au><au>Jeffery, Emily</au><au>Galvão, Daniel A.</au><au>Peddle‐McIntyre, Carolyn J.</au><au>Spry, Nigel</au><au>Joseph, David</au><au>Denham, James W.</au><au>Taaffe, Dennis R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Body composition, fatigue and exercise in patients with prostate cancer undergoing androgen‐deprivation therapy</atitle><jtitle>BJU international</jtitle><addtitle>BJU Int</addtitle><date>2018-12</date><risdate>2018</risdate><volume>122</volume><issue>6</issue><spage>986</spage><epage>993</epage><pages>986-993</pages><issn>1464-4096</issn><eissn>1464-410X</eissn><abstract>Objectives
To investigate the association between lean mass (LM) and fat mass (FM) with fatigue and vitality before and after exercise in patients with prostate cancer already undergoing androgen‐deprivation therapy (ADT).
Subjects and Methods
Cross‐sectional associations between LM and FM with fatigue and/or vitality measures were examined in 229 patients (aged 43–90 years). Prospective analysis was undertaken in 129 patients who underwent a supervised 3–6 months exercise programme (predominantly resistance + aerobic). Whole body and appendicular LM, and total and trunk FM were assessed by dual X‐ray absorptiometry. Fatigue was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire‐Core 30 (EORTC QLQ‐30) and vitality using the Short Form‐36.
Results
Based on the EORTC QLQ‐30, 19% of patients had clinically relevant fatigue. There was no association between LM and fatigue; however, total (P = 0.013), trunk (P = 0.015) and percentage (P = 0.008) FM were higher in fatigued than not fatigued patients, with total and trunk FM 5.0 and 2.6 kg higher, respectively. For quartiles of vitality, a similar pattern emerged for FM with those in the lowest quartile of vitality having the highest FM values (P = 0.014–0.034). In contrast, following supervised exercise, change in fatigue and vitality were associated with change in total LM (r = −0.182, P = 0.042 and r = 0.309, P = 0.001, respectively) but not FM. Patients fatigued at baseline but not fatigued following the exercise programme gained a median (interquartile range) of 2.1 (0.7–3.2) kg LM.
Conclusion
In patients with prostate cancer treated with ADT, body composition is associated with fatigue, with higher total and trunk FM in those with clinically relevant fatigue. However, following exercise those no longer fatigued had an accompanying substantial increase in LM. Modifying body composition, both LM and FM, in patients with prostate cancer may favourably alter cancer‐related fatigue levels and should be a target of exercise medicine in this population.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29750398</pmid><doi>10.1111/bju.14384</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-9463-3196</orcidid><orcidid>https://orcid.org/0000-0001-6381-1597</orcidid><orcidid>https://orcid.org/0000-0003-0302-6129</orcidid><orcidid>https://orcid.org/0000-0001-9913-4022</orcidid><orcidid>https://orcid.org/0000-0001-8659-5065</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Absorptiometry Adult Aged Aged, 80 and over Androgen Antagonists - adverse effects Androgen Antagonists - therapeutic use Androgens androgen‐deprivation therapy Antineoplastic Agents, Hormonal - adverse effects Antineoplastic Agents, Hormonal - therapeutic use Body composition Body Composition - drug effects Body fat Cross-Sectional Studies Exercise Exercise Therapy Exercise Tolerance - physiology Fatigue Fatigue - chemically induced Fatigue - physiopathology Fatigue - rehabilitation Humans Male Middle Aged Muscle Strength - drug effects Muscle, Skeletal - drug effects Patients PCSM Prospective Studies Prostate cancer ProstateCancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - physiopathology Prostatic Neoplasms - rehabilitation Quality of life Resistance Training Treatment Outcome |
| title | Body composition, fatigue and exercise in patients with prostate cancer undergoing androgen‐deprivation therapy |
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