Structural changes of macula and optic disk of the fellow eye in patients with nonarteritic anterior ischemic optic neuropathy
Purpose The aim was to assess the ganglion cell complex (GCC) thickness, retinal nerve fiber layer (RNFL) thickness and optic disk features in the affected eyes (AE) and unaffected fellow eyes (FE) of subjects with unilateral nonarteritic anterior ischemic optic neuropathy (NAION) and to compare wit...
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| Veröffentlicht in: | International ophthalmology 2019-06, Vol.39 (6), p.1293-1298 |
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| creator | Duman, R. Yavas, G. F. Veliyev, I. Dogan, M. Duman, R. |
| description | Purpose
The aim was to assess the ganglion cell complex (GCC) thickness, retinal nerve fiber layer (RNFL) thickness and optic disk features in the affected eyes (AE) and unaffected fellow eyes (FE) of subjects with unilateral nonarteritic anterior ischemic optic neuropathy (NAION) and to compare with healthy control eyes (CE) using spectral domain-optical coherence tomography (SD-OCT).
Methods
This study included 28 patients and age, sex and refraction-matched 28 control subjects. Mean GCC thickness and peripapillary RNFL thickness in four quadrants measured by cirrus SD-OCT were evaluated in both AE and FE of patients and CE. In addition, optic disk measurements obtained with OCT were evaluated.
Results
Mean GCC thickness was significantly lower in AE compared with both FE and CE (
P |
| doi_str_mv | 10.1007/s10792-018-0942-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2038268146</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2038268146</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-a5bfe6b2effa8ca7b87c1b036fa9ba5b1c9732916a987b4da2f9c82ee559d7073</originalsourceid><addsrcrecordid>eNp1kU-P1SAUxYlx4jxHP4AbQ-LGTR2gr1CWZjL-SSZxoa7JLb3Yji08gWbSzXz2oemoiYkrCOd3DhcOIa84e8cZU5eJM6VFxXhbMX0U1fqEHHij6krImj0lB8ZlUzWK8XPyPKVbxphWWj4j50Kro25keyD3X3NcbF4iTNQO4H9gosHRGewyAQXf03DKo6X9mH5uQh6QOpymcEdxRTp6eoI8os-J3o15oD54iBnjuJnAb7sQ6ZjsgHM52cM8LjEU37C-IGcOpoQvH9cL8v3D9berT9XNl4-fr97fVLZWIlfQdA5lJ9A5aC2orlWWd6yWDnRXRG61qoXmEnSrumMPwmnbCsSm0b1iqr4gb_fcUwy_FkzZzGWm8g7wGJZkBKtbIVt-lAV98w96G5boy3QbJTUvX68LxXfKxpBSRGdOcZwhroYzs5Vj9nJMKcds5Zi1eF4_Ji_djP0fx-82CiB2IBWpVBH_Xv3_1Adh151R</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2036911009</pqid></control><display><type>article</type><title>Structural changes of macula and optic disk of the fellow eye in patients with nonarteritic anterior ischemic optic neuropathy</title><source>SpringerLink Journals - AutoHoldings</source><creator>Duman, R. ; Yavas, G. F. ; Veliyev, I. ; Dogan, M. ; Duman, R.</creator><creatorcontrib>Duman, R. ; Yavas, G. F. ; Veliyev, I. ; Dogan, M. ; Duman, R.</creatorcontrib><description>Purpose
The aim was to assess the ganglion cell complex (GCC) thickness, retinal nerve fiber layer (RNFL) thickness and optic disk features in the affected eyes (AE) and unaffected fellow eyes (FE) of subjects with unilateral nonarteritic anterior ischemic optic neuropathy (NAION) and to compare with healthy control eyes (CE) using spectral domain-optical coherence tomography (SD-OCT).
Methods
This study included 28 patients and age, sex and refraction-matched 28 control subjects. Mean GCC thickness and peripapillary RNFL thickness in four quadrants measured by cirrus SD-OCT were evaluated in both AE and FE of patients and CE. In addition, optic disk measurements obtained with OCT were evaluated.
Results
Mean GCC thickness was significantly lower in AE compared with both FE and CE (
P
< 0.001), and mean GCC thickness in FE was significantly lower than CE (
P
= 0.022). In addition, mean RNFL thickness in superior and nasal quadrants significantly decreased in FE compared with CE (
P
= 0.020 and 0.010, respectively). Furthermore, AE had significantly greater optic disk cupping compared with both FE and CE (
P
< 0.001).
Conclusions
GCC and RNFL thickness decreased significantly at late stages of NAION, in both AE and FE compared with CE, suggesting that some subclinical structural changes may occur in FE despite lack of obvious visual symptoms. In addition, there was no significant difference in optic disk features between the CE and FE. And significantly greater optic disk cupping in the AE compared with both FE and CE supports the acquired enlargement of cupping after the onset of NAION.</description><identifier>ISSN: 0165-5701</identifier><identifier>EISSN: 1573-2630</identifier><identifier>DOI: 10.1007/s10792-018-0942-y</identifier><identifier>PMID: 29749568</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Enlargement ; Eye ; Eye (anatomy) ; Iron ; Ischemia ; Medicine ; Medicine & Public Health ; Ophthalmology ; Optic neuropathy ; Optical Coherence Tomography ; Original Paper ; Patients ; Quadrants ; Retina ; Thickness</subject><ispartof>International ophthalmology, 2019-06, Vol.39 (6), p.1293-1298</ispartof><rights>Springer Science+Business Media B.V., part of Springer Nature 2018</rights><rights>International Ophthalmology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-a5bfe6b2effa8ca7b87c1b036fa9ba5b1c9732916a987b4da2f9c82ee559d7073</citedby><cites>FETCH-LOGICAL-c372t-a5bfe6b2effa8ca7b87c1b036fa9ba5b1c9732916a987b4da2f9c82ee559d7073</cites><orcidid>0000-0002-8079-6250</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10792-018-0942-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10792-018-0942-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29749568$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duman, R.</creatorcontrib><creatorcontrib>Yavas, G. F.</creatorcontrib><creatorcontrib>Veliyev, I.</creatorcontrib><creatorcontrib>Dogan, M.</creatorcontrib><creatorcontrib>Duman, R.</creatorcontrib><title>Structural changes of macula and optic disk of the fellow eye in patients with nonarteritic anterior ischemic optic neuropathy</title><title>International ophthalmology</title><addtitle>Int Ophthalmol</addtitle><addtitle>Int Ophthalmol</addtitle><description>Purpose
The aim was to assess the ganglion cell complex (GCC) thickness, retinal nerve fiber layer (RNFL) thickness and optic disk features in the affected eyes (AE) and unaffected fellow eyes (FE) of subjects with unilateral nonarteritic anterior ischemic optic neuropathy (NAION) and to compare with healthy control eyes (CE) using spectral domain-optical coherence tomography (SD-OCT).
Methods
This study included 28 patients and age, sex and refraction-matched 28 control subjects. Mean GCC thickness and peripapillary RNFL thickness in four quadrants measured by cirrus SD-OCT were evaluated in both AE and FE of patients and CE. In addition, optic disk measurements obtained with OCT were evaluated.
Results
Mean GCC thickness was significantly lower in AE compared with both FE and CE (
P
< 0.001), and mean GCC thickness in FE was significantly lower than CE (
P
= 0.022). In addition, mean RNFL thickness in superior and nasal quadrants significantly decreased in FE compared with CE (
P
= 0.020 and 0.010, respectively). Furthermore, AE had significantly greater optic disk cupping compared with both FE and CE (
P
< 0.001).
Conclusions
GCC and RNFL thickness decreased significantly at late stages of NAION, in both AE and FE compared with CE, suggesting that some subclinical structural changes may occur in FE despite lack of obvious visual symptoms. In addition, there was no significant difference in optic disk features between the CE and FE. And significantly greater optic disk cupping in the AE compared with both FE and CE supports the acquired enlargement of cupping after the onset of NAION.</description><subject>Enlargement</subject><subject>Eye</subject><subject>Eye (anatomy)</subject><subject>Iron</subject><subject>Ischemia</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Optic neuropathy</subject><subject>Optical Coherence Tomography</subject><subject>Original Paper</subject><subject>Patients</subject><subject>Quadrants</subject><subject>Retina</subject><subject>Thickness</subject><issn>0165-5701</issn><issn>1573-2630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU-P1SAUxYlx4jxHP4AbQ-LGTR2gr1CWZjL-SSZxoa7JLb3Yji08gWbSzXz2oemoiYkrCOd3DhcOIa84e8cZU5eJM6VFxXhbMX0U1fqEHHij6krImj0lB8ZlUzWK8XPyPKVbxphWWj4j50Kro25keyD3X3NcbF4iTNQO4H9gosHRGewyAQXf03DKo6X9mH5uQh6QOpymcEdxRTp6eoI8os-J3o15oD54iBnjuJnAb7sQ6ZjsgHM52cM8LjEU37C-IGcOpoQvH9cL8v3D9berT9XNl4-fr97fVLZWIlfQdA5lJ9A5aC2orlWWd6yWDnRXRG61qoXmEnSrumMPwmnbCsSm0b1iqr4gb_fcUwy_FkzZzGWm8g7wGJZkBKtbIVt-lAV98w96G5boy3QbJTUvX68LxXfKxpBSRGdOcZwhroYzs5Vj9nJMKcds5Zi1eF4_Ji_djP0fx-82CiB2IBWpVBH_Xv3_1Adh151R</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Duman, R.</creator><creator>Yavas, G. F.</creator><creator>Veliyev, I.</creator><creator>Dogan, M.</creator><creator>Duman, R.</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8079-6250</orcidid></search><sort><creationdate>20190601</creationdate><title>Structural changes of macula and optic disk of the fellow eye in patients with nonarteritic anterior ischemic optic neuropathy</title><author>Duman, R. ; Yavas, G. F. ; Veliyev, I. ; Dogan, M. ; Duman, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-a5bfe6b2effa8ca7b87c1b036fa9ba5b1c9732916a987b4da2f9c82ee559d7073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Enlargement</topic><topic>Eye</topic><topic>Eye (anatomy)</topic><topic>Iron</topic><topic>Ischemia</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Optic neuropathy</topic><topic>Optical Coherence Tomography</topic><topic>Original Paper</topic><topic>Patients</topic><topic>Quadrants</topic><topic>Retina</topic><topic>Thickness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duman, R.</creatorcontrib><creatorcontrib>Yavas, G. F.</creatorcontrib><creatorcontrib>Veliyev, I.</creatorcontrib><creatorcontrib>Dogan, M.</creatorcontrib><creatorcontrib>Duman, R.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duman, R.</au><au>Yavas, G. F.</au><au>Veliyev, I.</au><au>Dogan, M.</au><au>Duman, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural changes of macula and optic disk of the fellow eye in patients with nonarteritic anterior ischemic optic neuropathy</atitle><jtitle>International ophthalmology</jtitle><stitle>Int Ophthalmol</stitle><addtitle>Int Ophthalmol</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>39</volume><issue>6</issue><spage>1293</spage><epage>1298</epage><pages>1293-1298</pages><issn>0165-5701</issn><eissn>1573-2630</eissn><abstract>Purpose
The aim was to assess the ganglion cell complex (GCC) thickness, retinal nerve fiber layer (RNFL) thickness and optic disk features in the affected eyes (AE) and unaffected fellow eyes (FE) of subjects with unilateral nonarteritic anterior ischemic optic neuropathy (NAION) and to compare with healthy control eyes (CE) using spectral domain-optical coherence tomography (SD-OCT).
Methods
This study included 28 patients and age, sex and refraction-matched 28 control subjects. Mean GCC thickness and peripapillary RNFL thickness in four quadrants measured by cirrus SD-OCT were evaluated in both AE and FE of patients and CE. In addition, optic disk measurements obtained with OCT were evaluated.
Results
Mean GCC thickness was significantly lower in AE compared with both FE and CE (
P
< 0.001), and mean GCC thickness in FE was significantly lower than CE (
P
= 0.022). In addition, mean RNFL thickness in superior and nasal quadrants significantly decreased in FE compared with CE (
P
= 0.020 and 0.010, respectively). Furthermore, AE had significantly greater optic disk cupping compared with both FE and CE (
P
< 0.001).
Conclusions
GCC and RNFL thickness decreased significantly at late stages of NAION, in both AE and FE compared with CE, suggesting that some subclinical structural changes may occur in FE despite lack of obvious visual symptoms. In addition, there was no significant difference in optic disk features between the CE and FE. And significantly greater optic disk cupping in the AE compared with both FE and CE supports the acquired enlargement of cupping after the onset of NAION.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>29749568</pmid><doi>10.1007/s10792-018-0942-y</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-8079-6250</orcidid></addata></record> |
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| ispartof | International ophthalmology, 2019-06, Vol.39 (6), p.1293-1298 |
| issn | 0165-5701 1573-2630 |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Enlargement Eye Eye (anatomy) Iron Ischemia Medicine Medicine & Public Health Ophthalmology Optic neuropathy Optical Coherence Tomography Original Paper Patients Quadrants Retina Thickness |
| title | Structural changes of macula and optic disk of the fellow eye in patients with nonarteritic anterior ischemic optic neuropathy |
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