Expression analysis of ST3GAL4 transcripts in cervical cancer cells
ST3GAL4 gene expression is altered in different cancer types, including cervical cancer. Several mRNA transcripts have been reported for this gene; however, their expression levels in cervical cancer have not been analyzed. ST3GAL4 encodes for β‑galactosidase α‑2,3‑sialyltransferase 4, involved in t...
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| Veröffentlicht in: | Molecular medicine reports 2018-07, Vol.18 (1), p.617-621 |
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| creator | Roa-de La Cruz, Lorena Martínez-Morales, Patricia Morán-Cruz, Irene Milflores-Flores, Lorena Rosas-Murrieta, Nora González-Ramírez, César Ortiz-Mateos, Claudia Monterrosas-Santamaría, Ricardo González-Frías, Celestina Rodea-Ávila, Carlos Apresa-García, Teresa Aguilar-Lemarroy, Adriana Jave-Suarez, Luis Santos-López, Gerardo Reyes-Leyva, Julio Vallejo-Ruiz, Verónica |
| description | ST3GAL4 gene expression is altered in different cancer types, including cervical cancer. Several mRNA transcripts have been reported for this gene; however, their expression levels in cervical cancer have not been analyzed. ST3GAL4 encodes for β‑galactosidase α‑2,3‑sialyltransferase 4, involved in the biosynthesis of the tumour antigens sLe(x) and sulfo‑sLe(x). The present study evaluated the presence of three mRNA variants (V1, V2 and V3) in cervical cancer cell lines, detecting the three variants. Additionally, the expression level of the V1 transcript of the ST3GAL4 gene was determined by reverse transcription‑quantitative polymerase chain reaction in cervical cell lines and in normal, premalignant and cervical cancer tissue. The V1 transcript of the ST3GAL4 demonstrated significant decreased expression in premalignant and malignant cervical tissues. The results suggested that deregulation of this gene could occur prior to the presence of cancer and demonstrated the importance of evaluating the expression level of V1, and its association with disease progression. |
| doi_str_mv | 10.3892/mmr.2018.8938 |
| format | Article |
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Several mRNA transcripts have been reported for this gene; however, their expression levels in cervical cancer have not been analyzed. ST3GAL4 encodes for β‑galactosidase α‑2,3‑sialyltransferase 4, involved in the biosynthesis of the tumour antigens sLe(x) and sulfo‑sLe(x). The present study evaluated the presence of three mRNA variants (V1, V2 and V3) in cervical cancer cell lines, detecting the three variants. Additionally, the expression level of the V1 transcript of the ST3GAL4 gene was determined by reverse transcription‑quantitative polymerase chain reaction in cervical cell lines and in normal, premalignant and cervical cancer tissue. The V1 transcript of the ST3GAL4 demonstrated significant decreased expression in premalignant and malignant cervical tissues. The results suggested that deregulation of this gene could occur prior to the presence of cancer and demonstrated the importance of evaluating the expression level of V1, and its association with disease progression.</description><identifier>ISSN: 1791-2997</identifier><identifier>EISSN: 1791-3004</identifier><identifier>DOI: 10.3892/mmr.2018.8938</identifier><identifier>PMID: 29749491</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Adolescent ; Adult ; Aged ; Antigens ; Biopsy ; Care and treatment ; Cervical cancer ; Cervix ; Development and progression ; Disease Progression ; Female ; Gene expression ; Gene Expression Regulation, Neoplastic ; Genetic aspects ; Genotypes ; Health aspects ; Human papillomavirus ; Humans ; Middle Aged ; Polymerase chain reaction ; Reverse transcription ; RNA Isoforms - genetics ; Sialyltransferases - genetics ; Tumor cell lines ; Tumors ; Uterine Cervical Neoplasms - enzymology ; Uterine Cervical Neoplasms - genetics ; Young Adult ; β-Galactosidase</subject><ispartof>Molecular medicine reports, 2018-07, Vol.18 (1), p.617-621</ispartof><rights>COPYRIGHT 2018 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-2c801eaaa7f3e8a89f8c9d92885e2496f2420ad95849fde1212bd83af2aa398b3</citedby><cites>FETCH-LOGICAL-c493t-2c801eaaa7f3e8a89f8c9d92885e2496f2420ad95849fde1212bd83af2aa398b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29749491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roa-de La Cruz, Lorena</creatorcontrib><creatorcontrib>Martínez-Morales, Patricia</creatorcontrib><creatorcontrib>Morán-Cruz, Irene</creatorcontrib><creatorcontrib>Milflores-Flores, Lorena</creatorcontrib><creatorcontrib>Rosas-Murrieta, Nora</creatorcontrib><creatorcontrib>González-Ramírez, César</creatorcontrib><creatorcontrib>Ortiz-Mateos, Claudia</creatorcontrib><creatorcontrib>Monterrosas-Santamaría, Ricardo</creatorcontrib><creatorcontrib>González-Frías, Celestina</creatorcontrib><creatorcontrib>Rodea-Ávila, Carlos</creatorcontrib><creatorcontrib>Apresa-García, Teresa</creatorcontrib><creatorcontrib>Aguilar-Lemarroy, Adriana</creatorcontrib><creatorcontrib>Jave-Suarez, Luis</creatorcontrib><creatorcontrib>Santos-López, Gerardo</creatorcontrib><creatorcontrib>Reyes-Leyva, Julio</creatorcontrib><creatorcontrib>Vallejo-Ruiz, Verónica</creatorcontrib><title>Expression analysis of ST3GAL4 transcripts in cervical cancer cells</title><title>Molecular medicine reports</title><addtitle>Mol Med Rep</addtitle><description>ST3GAL4 gene expression is altered in different cancer types, including cervical cancer. Several mRNA transcripts have been reported for this gene; however, their expression levels in cervical cancer have not been analyzed. ST3GAL4 encodes for β‑galactosidase α‑2,3‑sialyltransferase 4, involved in the biosynthesis of the tumour antigens sLe(x) and sulfo‑sLe(x). The present study evaluated the presence of three mRNA variants (V1, V2 and V3) in cervical cancer cell lines, detecting the three variants. Additionally, the expression level of the V1 transcript of the ST3GAL4 gene was determined by reverse transcription‑quantitative polymerase chain reaction in cervical cell lines and in normal, premalignant and cervical cancer tissue. The V1 transcript of the ST3GAL4 demonstrated significant decreased expression in premalignant and malignant cervical tissues. The results suggested that deregulation of this gene could occur prior to the presence of cancer and demonstrated the importance of evaluating the expression level of V1, and its association with disease progression.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antigens</subject><subject>Biopsy</subject><subject>Care and treatment</subject><subject>Cervical cancer</subject><subject>Cervix</subject><subject>Development and progression</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genetic aspects</subject><subject>Genotypes</subject><subject>Health aspects</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Polymerase chain reaction</subject><subject>Reverse transcription</subject><subject>RNA Isoforms - genetics</subject><subject>Sialyltransferases - genetics</subject><subject>Tumor cell lines</subject><subject>Tumors</subject><subject>Uterine Cervical Neoplasms - 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genetics</topic><topic>Sialyltransferases - genetics</topic><topic>Tumor cell lines</topic><topic>Tumors</topic><topic>Uterine Cervical Neoplasms - enzymology</topic><topic>Uterine Cervical Neoplasms - genetics</topic><topic>Young Adult</topic><topic>β-Galactosidase</topic><toplevel>online_resources</toplevel><creatorcontrib>Roa-de La Cruz, Lorena</creatorcontrib><creatorcontrib>Martínez-Morales, Patricia</creatorcontrib><creatorcontrib>Morán-Cruz, Irene</creatorcontrib><creatorcontrib>Milflores-Flores, Lorena</creatorcontrib><creatorcontrib>Rosas-Murrieta, Nora</creatorcontrib><creatorcontrib>González-Ramírez, César</creatorcontrib><creatorcontrib>Ortiz-Mateos, Claudia</creatorcontrib><creatorcontrib>Monterrosas-Santamaría, Ricardo</creatorcontrib><creatorcontrib>González-Frías, Celestina</creatorcontrib><creatorcontrib>Rodea-Ávila, Carlos</creatorcontrib><creatorcontrib>Apresa-García, Teresa</creatorcontrib><creatorcontrib>Aguilar-Lemarroy, Adriana</creatorcontrib><creatorcontrib>Jave-Suarez, Luis</creatorcontrib><creatorcontrib>Santos-López, Gerardo</creatorcontrib><creatorcontrib>Reyes-Leyva, Julio</creatorcontrib><creatorcontrib>Vallejo-Ruiz, Verónica</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular medicine reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roa-de La Cruz, Lorena</au><au>Martínez-Morales, Patricia</au><au>Morán-Cruz, Irene</au><au>Milflores-Flores, Lorena</au><au>Rosas-Murrieta, Nora</au><au>González-Ramírez, César</au><au>Ortiz-Mateos, Claudia</au><au>Monterrosas-Santamaría, Ricardo</au><au>González-Frías, Celestina</au><au>Rodea-Ávila, Carlos</au><au>Apresa-García, Teresa</au><au>Aguilar-Lemarroy, Adriana</au><au>Jave-Suarez, Luis</au><au>Santos-López, Gerardo</au><au>Reyes-Leyva, Julio</au><au>Vallejo-Ruiz, Verónica</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression analysis of ST3GAL4 transcripts in cervical cancer cells</atitle><jtitle>Molecular medicine reports</jtitle><addtitle>Mol Med Rep</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>18</volume><issue>1</issue><spage>617</spage><epage>621</epage><pages>617-621</pages><issn>1791-2997</issn><eissn>1791-3004</eissn><abstract>ST3GAL4 gene expression is altered in different cancer types, including cervical cancer. Several mRNA transcripts have been reported for this gene; however, their expression levels in cervical cancer have not been analyzed. ST3GAL4 encodes for β‑galactosidase α‑2,3‑sialyltransferase 4, involved in the biosynthesis of the tumour antigens sLe(x) and sulfo‑sLe(x). The present study evaluated the presence of three mRNA variants (V1, V2 and V3) in cervical cancer cell lines, detecting the three variants. Additionally, the expression level of the V1 transcript of the ST3GAL4 gene was determined by reverse transcription‑quantitative polymerase chain reaction in cervical cell lines and in normal, premalignant and cervical cancer tissue. The V1 transcript of the ST3GAL4 demonstrated significant decreased expression in premalignant and malignant cervical tissues. The results suggested that deregulation of this gene could occur prior to the presence of cancer and demonstrated the importance of evaluating the expression level of V1, and its association with disease progression.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>29749491</pmid><doi>10.3892/mmr.2018.8938</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Molecular medicine reports, 2018-07, Vol.18 (1), p.617-621 |
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| source | Spandidos Publications Journals; MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Antigens Biopsy Care and treatment Cervical cancer Cervix Development and progression Disease Progression Female Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Genotypes Health aspects Human papillomavirus Humans Middle Aged Polymerase chain reaction Reverse transcription RNA Isoforms - genetics Sialyltransferases - genetics Tumor cell lines Tumors Uterine Cervical Neoplasms - enzymology Uterine Cervical Neoplasms - genetics Young Adult β-Galactosidase |
| title | Expression analysis of ST3GAL4 transcripts in cervical cancer cells |
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