Retinoic acid inhibits neuronal voltage-gated calcium channels

[Display omitted] •Retinoic acid inhibited voltage-gated calcium channels.•The all-trans, but not the 9-cis, retinoid isomer inhibited the calcium current.•Both L-type and non-L-type channels were inhibited.•AtRA delayed rate of channel activation but increased rate of deactivation.•Retinoid recepto...

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Veröffentlicht in:	Cell calcium (Edinburgh) 2018-06, Vol.72, p.51-61
Hauptverfasser:	de Hoog, Eric, Lukewich, Mark K., Spencer, Gaynor E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium Channels - metabolism Ion Channel Gating - drug effects Kinetics L-type channels Mollusca - drug effects Mollusca - metabolism Nervous system Neurons - drug effects Neurons - metabolism non-L-type channels RAR Retinoids RXR Tretinoin - agonists Tretinoin - pharmacology Voltage-clamp
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