The possible effect of human menopausal gonadotropin on the audio-vestibular system
Human menopausal gonadotropin (HMG) is one of the commonest drugs used for ovarian stimulation with no reports on the audio-vestibular system. This study aims to examine HMG on the hearing profile of patients planning intracytoplasmic sperm injection (ICSI). This prospective study was conducted from...
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| Veröffentlicht in: | Auris, nasus, larynx nasus, larynx, 2018-12, Vol.45 (6), p.1166-1172 |
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| container_title | Auris, nasus, larynx |
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| creator | Abdel-Salam, Montaser Abdel-Naby Awad, Osama G. El-Badry, Mohamed Ibrahim, Ahmed Ibrahiem, Mahmoud Hosny |
| description | Human menopausal gonadotropin (HMG) is one of the commonest drugs used for ovarian stimulation with no reports on the audio-vestibular system. This study aims to examine HMG on the hearing profile of patients planning intracytoplasmic sperm injection (ICSI).
This prospective study was conducted from June 2016 to June 2017 in a tertiary referral hospital. The audio-vestibular system of a total of 30 patients was evaluated using pure tone audiometry, distortion product otoacoustic emissions (DPOAEs in the form of a DP-gram) and Vestibular-evoked myogenic potential (VEMP) immediately before therapy and at the day 10 after therapy. Audio-vestibular adverse effects including hearing loss, tinnitus, vertigo, and otalgia were also considered.
Significant elevations in hearing thresholds were found on comparing thresholds at the day 10 at the onset of the study. The elevations were mostly at frequencies (1000, 2000 and 8000Hz) and did not affect speech perception. For DPOAE, significant differences were observed at all F2 frequencies on comparing both amplitudes and signal to noise ratios. Otologic complaints were significant for tinnitus and hearing loss.
Significant auditory and vestibular adverse effects may result from HMG therapy, indicating the importance of prompt monitoring of auditory functions in these patients. |
| doi_str_mv | 10.1016/j.anl.2018.04.007 |
| format | Article |
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This prospective study was conducted from June 2016 to June 2017 in a tertiary referral hospital. The audio-vestibular system of a total of 30 patients was evaluated using pure tone audiometry, distortion product otoacoustic emissions (DPOAEs in the form of a DP-gram) and Vestibular-evoked myogenic potential (VEMP) immediately before therapy and at the day 10 after therapy. Audio-vestibular adverse effects including hearing loss, tinnitus, vertigo, and otalgia were also considered.
Significant elevations in hearing thresholds were found on comparing thresholds at the day 10 at the onset of the study. The elevations were mostly at frequencies (1000, 2000 and 8000Hz) and did not affect speech perception. For DPOAE, significant differences were observed at all F2 frequencies on comparing both amplitudes and signal to noise ratios. Otologic complaints were significant for tinnitus and hearing loss.
Significant auditory and vestibular adverse effects may result from HMG therapy, indicating the importance of prompt monitoring of auditory functions in these patients.</description><identifier>ISSN: 0385-8146</identifier><identifier>EISSN: 1879-1476</identifier><identifier>DOI: 10.1016/j.anl.2018.04.007</identifier><identifier>PMID: 29747963</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Audiometry ; Audiometry, Pure-Tone ; Auditory Threshold - physiology ; Distortion product ctoacoustic emissions (DPOAEs) ; Earache - chemically induced ; Earache - physiopathology ; Female ; Fertility Agents, Female - adverse effects ; Fertility Agents, Female - therapeutic use ; Hearing Loss - chemically induced ; Hearing Loss - physiopathology ; Human menopausal gonadotropin (HMG) ; Humans ; Infertility, Female - drug therapy ; Menotropins - adverse effects ; Menotropins - therapeutic use ; Otoacoustic Emissions, Spontaneous - physiology ; Ovulation Induction - methods ; Prospective Studies ; Signal-To-Noise Ratio ; Speech Perception - physiology ; Tinnitus - chemically induced ; Tinnitus - physiopathology ; Vertigo - chemically induced ; Vertigo - physiopathology ; Vestibular Evoked Myogenic Potentials - physiology ; Vestibular-evoked myogenic potential (VEMP) ; Young Adult</subject><ispartof>Auris, nasus, larynx, 2018-12, Vol.45 (6), p.1166-1172</ispartof><rights>2018 Elsevier B.V.</rights><rights>Copyright © 2018 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-a733d3b81a8b807bc184341e7b38317b588eb78084d666af6ecdc69f168632fb3</citedby><cites>FETCH-LOGICAL-c377t-a733d3b81a8b807bc184341e7b38317b588eb78084d666af6ecdc69f168632fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.anl.2018.04.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29747963$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abdel-Salam, Montaser</creatorcontrib><creatorcontrib>Abdel-Naby Awad, Osama G.</creatorcontrib><creatorcontrib>El-Badry, Mohamed</creatorcontrib><creatorcontrib>Ibrahim, Ahmed</creatorcontrib><creatorcontrib>Ibrahiem, Mahmoud Hosny</creatorcontrib><title>The possible effect of human menopausal gonadotropin on the audio-vestibular system</title><title>Auris, nasus, larynx</title><addtitle>Auris Nasus Larynx</addtitle><description>Human menopausal gonadotropin (HMG) is one of the commonest drugs used for ovarian stimulation with no reports on the audio-vestibular system. This study aims to examine HMG on the hearing profile of patients planning intracytoplasmic sperm injection (ICSI).
This prospective study was conducted from June 2016 to June 2017 in a tertiary referral hospital. The audio-vestibular system of a total of 30 patients was evaluated using pure tone audiometry, distortion product otoacoustic emissions (DPOAEs in the form of a DP-gram) and Vestibular-evoked myogenic potential (VEMP) immediately before therapy and at the day 10 after therapy. Audio-vestibular adverse effects including hearing loss, tinnitus, vertigo, and otalgia were also considered.
Significant elevations in hearing thresholds were found on comparing thresholds at the day 10 at the onset of the study. The elevations were mostly at frequencies (1000, 2000 and 8000Hz) and did not affect speech perception. For DPOAE, significant differences were observed at all F2 frequencies on comparing both amplitudes and signal to noise ratios. Otologic complaints were significant for tinnitus and hearing loss.
Significant auditory and vestibular adverse effects may result from HMG therapy, indicating the importance of prompt monitoring of auditory functions in these patients.</description><subject>Adult</subject><subject>Audiometry</subject><subject>Audiometry, Pure-Tone</subject><subject>Auditory Threshold - physiology</subject><subject>Distortion product ctoacoustic emissions (DPOAEs)</subject><subject>Earache - chemically induced</subject><subject>Earache - physiopathology</subject><subject>Female</subject><subject>Fertility Agents, Female - adverse effects</subject><subject>Fertility Agents, Female - therapeutic use</subject><subject>Hearing Loss - chemically induced</subject><subject>Hearing Loss - physiopathology</subject><subject>Human menopausal gonadotropin (HMG)</subject><subject>Humans</subject><subject>Infertility, Female - drug therapy</subject><subject>Menotropins - adverse effects</subject><subject>Menotropins - therapeutic use</subject><subject>Otoacoustic Emissions, Spontaneous - physiology</subject><subject>Ovulation Induction - methods</subject><subject>Prospective Studies</subject><subject>Signal-To-Noise Ratio</subject><subject>Speech Perception - physiology</subject><subject>Tinnitus - chemically induced</subject><subject>Tinnitus - physiopathology</subject><subject>Vertigo - chemically induced</subject><subject>Vertigo - physiopathology</subject><subject>Vestibular Evoked Myogenic Potentials - physiology</subject><subject>Vestibular-evoked myogenic potential (VEMP)</subject><subject>Young Adult</subject><issn>0385-8146</issn><issn>1879-1476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAURS0EglL4ASzII0uCHae2IyaE-JIqMVBmy3ZeqKskDnaC1H-PqxZGprece_XuQeiKkpwSym83ue7bvCBU5qTMCRFHaEalqDJaCn6MZoTJRSZpyc_QeYwbQggTrDpFZ0UlSlFxNkPvqzXgwcfoTAsYmgbsiH2D11One9xB7wc9Rd3iT9_r2o_BD67Hvsdjyumpdj77hjg6M7U64LiNI3QX6KTRbYTLw52jj6fH1cNLtnx7fn24X2aWCTFmWjBWMyOplkYSYSyVJSspCMMko8IspAQjJJFlzTnXDQdbW141lEvOisawObrZ9w7Bf03pC9W5aKFtdQ9-iqpI-wvOBFkklO5RG9LWAI0agut02CpK1M6l2qjkUu1cKlKq5DJlrg_1k-mg_kv8ykvA3R6ANPLbQVDROugt1C4kjar27p_6HxjehPc</recordid><startdate>201812</startdate><enddate>201812</enddate><creator>Abdel-Salam, Montaser</creator><creator>Abdel-Naby Awad, Osama G.</creator><creator>El-Badry, Mohamed</creator><creator>Ibrahim, Ahmed</creator><creator>Ibrahiem, Mahmoud Hosny</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201812</creationdate><title>The possible effect of human menopausal gonadotropin on the audio-vestibular system</title><author>Abdel-Salam, Montaser ; Abdel-Naby Awad, Osama G. ; El-Badry, Mohamed ; Ibrahim, Ahmed ; Ibrahiem, Mahmoud Hosny</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-a733d3b81a8b807bc184341e7b38317b588eb78084d666af6ecdc69f168632fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Audiometry</topic><topic>Audiometry, Pure-Tone</topic><topic>Auditory Threshold - physiology</topic><topic>Distortion product ctoacoustic emissions (DPOAEs)</topic><topic>Earache - chemically induced</topic><topic>Earache - physiopathology</topic><topic>Female</topic><topic>Fertility Agents, Female - adverse effects</topic><topic>Fertility Agents, Female - therapeutic use</topic><topic>Hearing Loss - chemically induced</topic><topic>Hearing Loss - physiopathology</topic><topic>Human menopausal gonadotropin (HMG)</topic><topic>Humans</topic><topic>Infertility, Female - drug therapy</topic><topic>Menotropins - adverse effects</topic><topic>Menotropins - therapeutic use</topic><topic>Otoacoustic Emissions, Spontaneous - physiology</topic><topic>Ovulation Induction - methods</topic><topic>Prospective Studies</topic><topic>Signal-To-Noise Ratio</topic><topic>Speech Perception - physiology</topic><topic>Tinnitus - chemically induced</topic><topic>Tinnitus - physiopathology</topic><topic>Vertigo - chemically induced</topic><topic>Vertigo - physiopathology</topic><topic>Vestibular Evoked Myogenic Potentials - physiology</topic><topic>Vestibular-evoked myogenic potential (VEMP)</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdel-Salam, Montaser</creatorcontrib><creatorcontrib>Abdel-Naby Awad, Osama G.</creatorcontrib><creatorcontrib>El-Badry, Mohamed</creatorcontrib><creatorcontrib>Ibrahim, Ahmed</creatorcontrib><creatorcontrib>Ibrahiem, Mahmoud Hosny</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Auris, nasus, larynx</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdel-Salam, Montaser</au><au>Abdel-Naby Awad, Osama G.</au><au>El-Badry, Mohamed</au><au>Ibrahim, Ahmed</au><au>Ibrahiem, Mahmoud Hosny</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The possible effect of human menopausal gonadotropin on the audio-vestibular system</atitle><jtitle>Auris, nasus, larynx</jtitle><addtitle>Auris Nasus Larynx</addtitle><date>2018-12</date><risdate>2018</risdate><volume>45</volume><issue>6</issue><spage>1166</spage><epage>1172</epage><pages>1166-1172</pages><issn>0385-8146</issn><eissn>1879-1476</eissn><abstract>Human menopausal gonadotropin (HMG) is one of the commonest drugs used for ovarian stimulation with no reports on the audio-vestibular system. This study aims to examine HMG on the hearing profile of patients planning intracytoplasmic sperm injection (ICSI).
This prospective study was conducted from June 2016 to June 2017 in a tertiary referral hospital. The audio-vestibular system of a total of 30 patients was evaluated using pure tone audiometry, distortion product otoacoustic emissions (DPOAEs in the form of a DP-gram) and Vestibular-evoked myogenic potential (VEMP) immediately before therapy and at the day 10 after therapy. Audio-vestibular adverse effects including hearing loss, tinnitus, vertigo, and otalgia were also considered.
Significant elevations in hearing thresholds were found on comparing thresholds at the day 10 at the onset of the study. The elevations were mostly at frequencies (1000, 2000 and 8000Hz) and did not affect speech perception. For DPOAE, significant differences were observed at all F2 frequencies on comparing both amplitudes and signal to noise ratios. Otologic complaints were significant for tinnitus and hearing loss.
Significant auditory and vestibular adverse effects may result from HMG therapy, indicating the importance of prompt monitoring of auditory functions in these patients.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>29747963</pmid><doi>10.1016/j.anl.2018.04.007</doi><tpages>7</tpages></addata></record> |
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| ispartof | Auris, nasus, larynx, 2018-12, Vol.45 (6), p.1166-1172 |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Adult Audiometry Audiometry, Pure-Tone Auditory Threshold - physiology Distortion product ctoacoustic emissions (DPOAEs) Earache - chemically induced Earache - physiopathology Female Fertility Agents, Female - adverse effects Fertility Agents, Female - therapeutic use Hearing Loss - chemically induced Hearing Loss - physiopathology Human menopausal gonadotropin (HMG) Humans Infertility, Female - drug therapy Menotropins - adverse effects Menotropins - therapeutic use Otoacoustic Emissions, Spontaneous - physiology Ovulation Induction - methods Prospective Studies Signal-To-Noise Ratio Speech Perception - physiology Tinnitus - chemically induced Tinnitus - physiopathology Vertigo - chemically induced Vertigo - physiopathology Vestibular Evoked Myogenic Potentials - physiology Vestibular-evoked myogenic potential (VEMP) Young Adult |
| title | The possible effect of human menopausal gonadotropin on the audio-vestibular system |
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