A naturally occuring triterpene saponin ardisiacrispin B displayed cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death

Multidrug resistance of cancer cells constitutes a serious problem in chemotherapy and a challenging issue in the discovery of new cytotoxic drugs. Many saponins are known to display anti-cancer effects. In this study, the cytotoxicity and the modes of action of a naturally occuring oleanane-type tr...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2018-04, Vol.43, p.78-85
Hauptverfasser:	Mbaveng, Armelle T., Ndontsa, Blanche L., Kuete, Victor, Nguekeu, Yves M.M., Çelik, İlhami, Mbouangouere, Roukayatou, Tane, Pierre, Efferth, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Ardisiacrispin B Cell cycle distribution Cytotoxicity Ferroptosis Mitochondrial membrane potential Saponin
Online-Zugang:	Volltext
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