Increased hyperalgesia by 5-nitro-2, 3-(phenylpropylamino)-benzoic acid (NPPB), a chloride channel blocker in crush injury-induced neuropathic pain in rats
Chloride channels belong to diverse group of anion selective channels involved in different signaling processes. The present study was planned to investigate the involvement of chloride channels in crush injury-induced neuropathic pain in rats by using ivermectin, a ligand gated chloride channel ope...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 2009, Vol.91 (3), p.417-422 |
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| creator | Ramteke, Vinod D. Tandan, Surendra K. Kumar, Dinesh Aruna Devi, R. Shukla, Manoj K. Ravi Prakash, Vellanki |
| description | Chloride channels belong to diverse group of anion selective channels involved in different signaling processes. The present study was planned to investigate the involvement of chloride channels in crush injury-induced neuropathic pain in rats by using ivermectin, a ligand gated chloride channel opener and NPPB, a CaCC blocker. The effect of ivermectin (5, 10, 20 mg/kg i.p. or 50, 100 and 200 μg/rat by i.c.v. route) and NPPB (10, 20 and 40 mg/kg i.p.) was investigated on pain behavioural thresholds in crush injury-induced neuropathic pain rat model. Reduction in pain threshold by mechanical, thermal and cold stimuli confirmed the development of neuropathic pain in rats after crush injury. Ivermectin administered either by i.p. or i.c.v. route did not alter the pain threshold in mechanical, thermal and, cold allodynia tests in rats. NPPB (20 and 40 mg/kg i.p.) significantly reduced the pain threshold crush injury neuropathic pain model suggesting its hyperalgesic effect. The results showed that NPPB increased significantly the mechanical and thermal hyperalgesia in crush injury-induced neuropathic pain rat model, whereas ivermectin, either by i.p. or i.c.v. route of administration, has no effect on pain symptoms in this model. NPPB hyperalgesic effect is independent of CaCCs inhibition and may be due to blockade of Ca
2+-activated K
+ channel. |
| doi_str_mv | 10.1016/j.pbb.2008.08.017 |
| format | Article |
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2+-activated K
+ channel.</description><subject>5-nitro-2, 3-(phenylpropylamino)-benzoic acid (NPPB)</subject><subject>Angiogenesis Inhibitors</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Chloride channel</subject><subject>Chloride Channels - antagonists & inhibitors</subject><subject>Cold Temperature</subject><subject>Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction</subject><subject>Hot Temperature</subject><subject>Hyperalgesia - chemically induced</subject><subject>Hyperalgesia - pathology</subject><subject>Hyperalgesia - psychology</subject><subject>Injections, Intraventricular</subject><subject>Ivermectin</subject><subject>Ivermectin - pharmacology</subject><subject>Ligands</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nerve Crush</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Neuropathic pain</subject><subject>Nitrobenzoates</subject><subject>Pain - pathology</subject><subject>Pain - psychology</subject><subject>Pain Threshold - drug effects</subject><subject>Peripheral Nervous System Diseases - pathology</subject><subject>Peripheral Nervous System Diseases - psychology</subject><subject>Physical Stimulation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU2LFDEQhoMo7rj6A7xILsoubI9J-iPdeNLFj4VF96DnUEmq7YyZdJt0C-1f8c-aYQa9ifBC6vDUm6p6CXnK2ZYz3rzcbSett4KxdnsQl_fIhreyLGou5X2yYazjRclqeUYepbRjjFWikQ_JWYZkLatyQ37dBBMRElo6rBNG8F8xOaB6pXUR3BzHQlzRsriYBgyrn-I4rR72LoyXhcbwc3SGgnGWXny8u3tzeUWBmsGP0VnMBYSAnmo_mm8YqQvUxCUNudgtcS1csIvJHwdcsi3MQ_aaIFNZEeb0mDzowSd8cnrPyZd3bz9ffyhuP72_uX59W5iqKucChK6qtuV9JdHo3oJgfd5fM90yW3cNmMqA4U0rep1lS142qDPUS0DR2PKcvDj65u2-L5hmtXfJoPcQcFySEqxsRcO7_wDzeTvJMsiPoIljShF7NUW3h7gqztQhOrVTOTp1iE4dxGXueXYyX_Qe7d-OU1YZeH4CIBnwfYRgXPrDCc5k23Y8c6-OHOab_XAYVTIOQ760i2hmZUf3jzF-A4H6uD0</recordid><startdate>2009</startdate><enddate>2009</enddate><creator>Ramteke, Vinod D.</creator><creator>Tandan, Surendra K.</creator><creator>Kumar, Dinesh</creator><creator>Aruna Devi, R.</creator><creator>Shukla, Manoj K.</creator><creator>Ravi Prakash, Vellanki</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope></search><sort><creationdate>2009</creationdate><title>Increased hyperalgesia by 5-nitro-2, 3-(phenylpropylamino)-benzoic acid (NPPB), a chloride channel blocker in crush injury-induced neuropathic pain in rats</title><author>Ramteke, Vinod D. ; Tandan, Surendra K. ; Kumar, Dinesh ; Aruna Devi, R. ; Shukla, Manoj K. ; Ravi Prakash, Vellanki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-a2b44881f47ecbfda20f177b0b80d596ac4cac1682fb2fbd3136eb20ff7ae26d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>5-nitro-2, 3-(phenylpropylamino)-benzoic acid (NPPB)</topic><topic>Angiogenesis Inhibitors</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Chloride channel</topic><topic>Chloride Channels - antagonists & inhibitors</topic><topic>Cold Temperature</topic><topic>Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction</topic><topic>Hot Temperature</topic><topic>Hyperalgesia - chemically induced</topic><topic>Hyperalgesia - pathology</topic><topic>Hyperalgesia - psychology</topic><topic>Injections, Intraventricular</topic><topic>Ivermectin</topic><topic>Ivermectin - pharmacology</topic><topic>Ligands</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nerve Crush</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Neuropathic pain</topic><topic>Nitrobenzoates</topic><topic>Pain - pathology</topic><topic>Pain - psychology</topic><topic>Pain Threshold - drug effects</topic><topic>Peripheral Nervous System Diseases - pathology</topic><topic>Peripheral Nervous System Diseases - psychology</topic><topic>Physical Stimulation</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramteke, Vinod D.</creatorcontrib><creatorcontrib>Tandan, Surendra K.</creatorcontrib><creatorcontrib>Kumar, Dinesh</creatorcontrib><creatorcontrib>Aruna Devi, R.</creatorcontrib><creatorcontrib>Shukla, Manoj K.</creatorcontrib><creatorcontrib>Ravi Prakash, Vellanki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramteke, Vinod D.</au><au>Tandan, Surendra K.</au><au>Kumar, Dinesh</au><au>Aruna Devi, R.</au><au>Shukla, Manoj K.</au><au>Ravi Prakash, Vellanki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased hyperalgesia by 5-nitro-2, 3-(phenylpropylamino)-benzoic acid (NPPB), a chloride channel blocker in crush injury-induced neuropathic pain in rats</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>2009</date><risdate>2009</risdate><volume>91</volume><issue>3</issue><spage>417</spage><epage>422</epage><pages>417-422</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>Chloride channels belong to diverse group of anion selective channels involved in different signaling processes. The present study was planned to investigate the involvement of chloride channels in crush injury-induced neuropathic pain in rats by using ivermectin, a ligand gated chloride channel opener and NPPB, a CaCC blocker. The effect of ivermectin (5, 10, 20 mg/kg i.p. or 50, 100 and 200 μg/rat by i.c.v. route) and NPPB (10, 20 and 40 mg/kg i.p.) was investigated on pain behavioural thresholds in crush injury-induced neuropathic pain rat model. Reduction in pain threshold by mechanical, thermal and cold stimuli confirmed the development of neuropathic pain in rats after crush injury. Ivermectin administered either by i.p. or i.c.v. route did not alter the pain threshold in mechanical, thermal and, cold allodynia tests in rats. NPPB (20 and 40 mg/kg i.p.) significantly reduced the pain threshold crush injury neuropathic pain model suggesting its hyperalgesic effect. The results showed that NPPB increased significantly the mechanical and thermal hyperalgesia in crush injury-induced neuropathic pain rat model, whereas ivermectin, either by i.p. or i.c.v. route of administration, has no effect on pain symptoms in this model. NPPB hyperalgesic effect is independent of CaCCs inhibition and may be due to blockade of Ca
2+-activated K
+ channel.</abstract><cop>Kidlington</cop><pub>Elsevier Inc</pub><pmid>18775743</pmid><doi>10.1016/j.pbb.2008.08.017</doi><tpages>6</tpages></addata></record> |
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| subjects | 5-nitro-2, 3-(phenylpropylamino)-benzoic acid (NPPB) Angiogenesis Inhibitors Animals Behavior, Animal - drug effects Biological and medical sciences Chloride channel Chloride Channels - antagonists & inhibitors Cold Temperature Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Hot Temperature Hyperalgesia - chemically induced Hyperalgesia - pathology Hyperalgesia - psychology Injections, Intraventricular Ivermectin Ivermectin - pharmacology Ligands Male Medical sciences Nerve Crush Nervous system (semeiology, syndromes) Neurology Neuropathic pain Nitrobenzoates Pain - pathology Pain - psychology Pain Threshold - drug effects Peripheral Nervous System Diseases - pathology Peripheral Nervous System Diseases - psychology Physical Stimulation Rats Rats, Wistar |
| title | Increased hyperalgesia by 5-nitro-2, 3-(phenylpropylamino)-benzoic acid (NPPB), a chloride channel blocker in crush injury-induced neuropathic pain in rats |
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