Alterations in gene expression profiles and the DNA-damage response in ionizing radiation-exposed TK6 cells

Identifying genes that are differentially expressed in response to DNA damage may help elucidate markers for genetic damage and provide insight into the cellular responses to specific genotoxic agents. We utilized cDNA microarrays to develop gene expression profiles for ionizing radiation‐exposed hu...

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Veröffentlicht in:	Environmental and molecular mutagenesis 2005, Vol.45 (2-3), p.188-205
Hauptverfasser:	Akerman, Gregory S., Rosenzweig, Barry A., Domon, Olen E., Tsai, Chen-An, Bishop, Michelle E., McGarrity, Lynda J., MacGregor, James T., Sistare, Frank D., Chen, James J., Morris, Suzanne M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Biological and medical sciences Cell Cycle - radiation effects Cell Survival - radiation effects DNA Damage DNA Primers Dose-Response Relationship, Radiation Flow Cytometry Fundamental and applied biological sciences. Psychology gene expression Gene Expression Profiling Gene Expression Regulation - radiation effects Genetics of eukaryotes. Biological and molecular evolution Humans ionizing radiation Medical sciences microarray Micronucleus Tests Oligonucleotide Array Sequence Analysis Radiation, Ionizing Reverse Transcriptase Polymerase Chain Reaction Thymidine Kinase - genetics Time Factors TK6 cells Toxicology Tumor Cells, Cultured
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