Histopathological lesions following intramuscular administration of saline in laboratory rodents and rabbits
This review was undertaken to assess the nature and incidence of procedure-related changes in mice, rats and rabbits which received saline solution by intramuscular injection. Data were collected on the injection sites from 7 studies representing 152 animals. The original observations by the differe...
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| Veröffentlicht in: | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2009, Vol.61 (1), p.13-21 |
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| container_title | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie |
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| creator | Thuilliez, Celine Dorso, Laetitia Howroyd, Paul Gould, Sarah Chanut, Franck Burnett, Roger |
| description | This review was undertaken to assess the nature and incidence of procedure-related changes in mice, rats and rabbits which received saline solution by intramuscular injection. Data were collected on the injection sites from 7 studies representing 152 animals. The original observations by the different study pathologists from both control and treated animals were evaluated in order to create a glossary of preferred terms to be used in toxicology studies.
These standardized terms were then applied to changes observed in the saline-treated animals. The review showed that the most severe of the procedure-related lesions were only of a slight level. Two days post-injection, the local reactions were mainly composed of minimal infiltration by mononuclear cells (lymphocytes and macrophages) with occasional degeneration of myofibres. From 10 to 42 days post-injection, lesions showed regeneration of myofibres and some fibrosis. In rats, the number of injections at each site influenced inflammatory infiltrate and degenerative lesions. |
| doi_str_mv | 10.1016/j.etp.2008.07.003 |
| format | Article |
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These standardized terms were then applied to changes observed in the saline-treated animals. The review showed that the most severe of the procedure-related lesions were only of a slight level. Two days post-injection, the local reactions were mainly composed of minimal infiltration by mononuclear cells (lymphocytes and macrophages) with occasional degeneration of myofibres. From 10 to 42 days post-injection, lesions showed regeneration of myofibres and some fibrosis. In rats, the number of injections at each site influenced inflammatory infiltrate and degenerative lesions.</description><identifier>ISSN: 0940-2993</identifier><identifier>EISSN: 1618-1433</identifier><identifier>DOI: 10.1016/j.etp.2008.07.003</identifier><identifier>PMID: 18835765</identifier><language>eng</language><publisher>Munich: Elsevier GmbH</publisher><subject>Animals ; Biological and medical sciences ; Female ; Inflammation - chemically induced ; Inflammation - pathology ; Injections, Intramuscular ; Intramuscular administration ; Intramuscular lesions ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Mice ; Mouse ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Rabbit ; Rabbits ; Rat ; Rats ; Rats, Wistar ; Saline ; Sodium Chloride - administration & dosage ; Sodium Chloride - toxicity ; Toxicology</subject><ispartof>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 2009, Vol.61 (1), p.13-21</ispartof><rights>2008 Elsevier GmbH</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-1fe20cd061365fa157ccccc2ffc713af0b4b29009550a47f9323b70a69dbb4883</citedby><cites>FETCH-LOGICAL-c479t-1fe20cd061365fa157ccccc2ffc713af0b4b29009550a47f9323b70a69dbb4883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S094029930800119X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21067140$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18835765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thuilliez, Celine</creatorcontrib><creatorcontrib>Dorso, Laetitia</creatorcontrib><creatorcontrib>Howroyd, Paul</creatorcontrib><creatorcontrib>Gould, Sarah</creatorcontrib><creatorcontrib>Chanut, Franck</creatorcontrib><creatorcontrib>Burnett, Roger</creatorcontrib><title>Histopathological lesions following intramuscular administration of saline in laboratory rodents and rabbits</title><title>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</title><addtitle>Exp Toxicol Pathol</addtitle><description>This review was undertaken to assess the nature and incidence of procedure-related changes in mice, rats and rabbits which received saline solution by intramuscular injection. Data were collected on the injection sites from 7 studies representing 152 animals. The original observations by the different study pathologists from both control and treated animals were evaluated in order to create a glossary of preferred terms to be used in toxicology studies.
These standardized terms were then applied to changes observed in the saline-treated animals. The review showed that the most severe of the procedure-related lesions were only of a slight level. Two days post-injection, the local reactions were mainly composed of minimal infiltration by mononuclear cells (lymphocytes and macrophages) with occasional degeneration of myofibres. From 10 to 42 days post-injection, lesions showed regeneration of myofibres and some fibrosis. In rats, the number of injections at each site influenced inflammatory infiltrate and degenerative lesions.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - pathology</subject><subject>Injections, Intramuscular</subject><subject>Intramuscular administration</subject><subject>Intramuscular lesions</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mouse</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscle, Skeletal - pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Rabbit</subject><subject>Rabbits</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Saline</subject><subject>Sodium Chloride - administration & dosage</subject><subject>Sodium Chloride - toxicity</subject><subject>Toxicology</subject><issn>0940-2993</issn><issn>1618-1433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMGKFDEQhoMo7rj6AF4kF711W0m6O9N4kkVdYcGLnkMlnawZ0smYpF327c0wg96sS0Hx_UXVR8hrBj0DNr0_9LYeew6w70H2AOIJ2bGJ7Ts2CPGU7GAeoOPzLK7Ii1IOABzmkT0nV2y_F6Ocxh0Jt77UdMT6M4V07w0GGmzxKRbqUgjpwcd76mPNuG7FbAEzxWX1saUy1sbR5GjB4KNtGA2oU5un_EhzWmyshWJcaEatfS0vyTOHodhXl35Nfnz-9P3mtrv79uXrzce7zgxyrh1zloNZYGJiGh2yUZpTceeMZAId6EHzGdovI-Ag3Sy40BJwmheth_baNXl33nvM6ddmS1WrL8aGgNGmrSgOQs7TeALZGTQ5lZKtU8fsV8yPioE6KVYH1RSrk2IFUjXFLfPmsnzTq13-JS5OG_D2AmBpPl3GaHz5y3EGk2QDNO7DmbNNxW9vsyrG22js4rM1VS3J_-eMP2hznD8</recordid><startdate>2009</startdate><enddate>2009</enddate><creator>Thuilliez, Celine</creator><creator>Dorso, Laetitia</creator><creator>Howroyd, Paul</creator><creator>Gould, Sarah</creator><creator>Chanut, Franck</creator><creator>Burnett, Roger</creator><general>Elsevier GmbH</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>2009</creationdate><title>Histopathological lesions following intramuscular administration of saline in laboratory rodents and rabbits</title><author>Thuilliez, Celine ; Dorso, Laetitia ; Howroyd, Paul ; Gould, Sarah ; Chanut, Franck ; Burnett, Roger</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-1fe20cd061365fa157ccccc2ffc713af0b4b29009550a47f9323b70a69dbb4883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation - pathology</topic><topic>Injections, Intramuscular</topic><topic>Intramuscular administration</topic><topic>Intramuscular lesions</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mouse</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Muscle, Skeletal - pathology</topic><topic>Pathology. 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Miscellaneous investigative techniques</topic><topic>Rabbit</topic><topic>Rabbits</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Saline</topic><topic>Sodium Chloride - administration & dosage</topic><topic>Sodium Chloride - toxicity</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thuilliez, Celine</creatorcontrib><creatorcontrib>Dorso, Laetitia</creatorcontrib><creatorcontrib>Howroyd, Paul</creatorcontrib><creatorcontrib>Gould, Sarah</creatorcontrib><creatorcontrib>Chanut, Franck</creatorcontrib><creatorcontrib>Burnett, Roger</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thuilliez, Celine</au><au>Dorso, Laetitia</au><au>Howroyd, Paul</au><au>Gould, Sarah</au><au>Chanut, Franck</au><au>Burnett, Roger</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histopathological lesions following intramuscular administration of saline in laboratory rodents and rabbits</atitle><jtitle>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</jtitle><addtitle>Exp Toxicol Pathol</addtitle><date>2009</date><risdate>2009</risdate><volume>61</volume><issue>1</issue><spage>13</spage><epage>21</epage><pages>13-21</pages><issn>0940-2993</issn><eissn>1618-1433</eissn><abstract>This review was undertaken to assess the nature and incidence of procedure-related changes in mice, rats and rabbits which received saline solution by intramuscular injection. 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These standardized terms were then applied to changes observed in the saline-treated animals. The review showed that the most severe of the procedure-related lesions were only of a slight level. Two days post-injection, the local reactions were mainly composed of minimal infiltration by mononuclear cells (lymphocytes and macrophages) with occasional degeneration of myofibres. From 10 to 42 days post-injection, lesions showed regeneration of myofibres and some fibrosis. In rats, the number of injections at each site influenced inflammatory infiltrate and degenerative lesions.</abstract><cop>Munich</cop><pub>Elsevier GmbH</pub><pmid>18835765</pmid><doi>10.1016/j.etp.2008.07.003</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Female Inflammation - chemically induced Inflammation - pathology Injections, Intramuscular Intramuscular administration Intramuscular lesions Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Mice Mouse Muscle, Skeletal - drug effects Muscle, Skeletal - pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Rabbit Rabbits Rat Rats Rats, Wistar Saline Sodium Chloride - administration & dosage Sodium Chloride - toxicity Toxicology |
| title | Histopathological lesions following intramuscular administration of saline in laboratory rodents and rabbits |
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