Granzyme B-induced Cell Death Involves Induction of p53 Tumor Suppressor Gene and Its Activation in Tumor Target Cells

In this study we investigated the involvement of p53 in cytotoxic T-lymphocyte (CTL)-induced tumor target cell killing mediated by the perforin/granzymes pathway. For this purpose we used a human CTL clone (LT12) that kills its autologous melanoma target cells (T1), harboring a wild type p53. We dem...

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Veröffentlicht in:	The Journal of biological chemistry 2007-11, Vol.282 (45), p.32991-32999
Hauptverfasser:	Meslin, Franck, Thiery, Jerome, Richon, Catherine, Jalil, Abdelali, Chouaib, Salem
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Bacterial Proteins - pharmacology Enzyme Activation Gene Expression Regulation, Neoplastic Granzymes - pharmacology Humans Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Perforin - metabolism Phosphorylation RNA, Small Interfering - genetics Signal Transduction Streptolysins - pharmacology T-Lymphocytes, Cytotoxic - drug effects T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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