Delivery strategies for antiparasitics
Optimisation of drug carrier systems and drug delivery strategies that take into account the peculiarities of individual infectious agents and diseases are key elements of modern drug development. In the following, different aspects of a rational design for antiparasitic drug formulation will be rev...
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| Veröffentlicht in: | Expert opinion on investigational drugs 2003-02, Vol.12 (2), p.197-207 |
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| container_title | Expert opinion on investigational drugs |
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| creator | Kayser, Oliver Kiderlen, Albrecht F |
| description | Optimisation of drug carrier systems and drug delivery strategies that take into account the peculiarities of individual infectious agents and diseases are key elements of modern drug development. In the following, different aspects of a rational design for antiparasitic drug formulation will be reviewed, covering delivery systems such as nano- and microparticles, liposomes, emulsions and microemulsions, cochleates and bioadhesive macromolecules. Functional properties for each carrier system will be discussed as well as their therapeutic efficacy for parasitic diseases, including leishmaniasis, human African trypanosomiasis, human cryptosporidiosis, malaria and schistosomiasis. Critical issues for the application of drug carrier systems will be discussed, focusing on biopharmaceutical and pathophysiological parameters such as routes of application, improvement of body distribution and targeting intracellularly persisting pathogens. |
| doi_str_mv | 10.1517/13543784.12.2.197 |
| format | Article |
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In the following, different aspects of a rational design for antiparasitic drug formulation will be reviewed, covering delivery systems such as nano- and microparticles, liposomes, emulsions and microemulsions, cochleates and bioadhesive macromolecules. Functional properties for each carrier system will be discussed as well as their therapeutic efficacy for parasitic diseases, including leishmaniasis, human African trypanosomiasis, human cryptosporidiosis, malaria and schistosomiasis. Critical issues for the application of drug carrier systems will be discussed, focusing on biopharmaceutical and pathophysiological parameters such as routes of application, improvement of body distribution and targeting intracellularly persisting pathogens.</description><subject>Administration, Cutaneous</subject><subject>Administration, Oral</subject><subject>amphotericin B</subject><subject>Animals</subject><subject>Antiparasitic Agents - administration & dosage</subject><subject>colloidal carriers</subject><subject>Dosage Forms</subject><subject>drug delivery</subject><subject>Drug Delivery Systems - methods</subject><subject>Humans</subject><subject>leishmaniasis</subject><subject>liposomes</subject><subject>malaria</subject><subject>nanoparticles</subject><subject>parasites</subject><subject>Parasitic Diseases - drug therapy</subject><subject>Parasitic Diseases - parasitology</subject><subject>Pulmonary Alveoli - drug effects</subject><subject>Pulmonary Alveoli - parasitology</subject><subject>Schistosoma</subject><subject>surfactants</subject><subject>Trachea - drug effects</subject><subject>Trachea - parasitology</subject><issn>1354-3784</issn><issn>1744-7658</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKAzEUhoMoVqsP4Ea66m7G3C_oRuoVCm66D5lMxqbMpSYzSt_elFbETT2bHMj3_xw-AK4QzBFD4gYRRomQNEc4xzlS4gicIUFpJjiTx2lP_9kWGIHzGFcQYqgYOQUjhBnjGNEzMH1wtf90YTOJfTC9e_cuTqouTEzb-7UJJvre23gBTipTR3e5f8dg8fS4mL1k87fn19n9PLOUkD4rCOS2cgxxCVkhrVW8lAQxbAi2zGBIHUcVllQxLErFqXIojbEFKQuJyRhMd7Xr0H0MLva68dG6ujat64aoBVaSc6X-BTEkgnEuE4h2oA1djMFVeh18Y8JGI6i3EvWPRI2wxjpJTJnrfflQNK78TeytJeBuB_g2qWrMVxfqUvdmU3ehCqa1PmpyqP_2T3zpTN0vrQlOr7ohtEnwgeu-AUh-kUk</recordid><startdate>20030201</startdate><enddate>20030201</enddate><creator>Kayser, Oliver</creator><creator>Kiderlen, Albrecht F</creator><general>Ashley Publications Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20030201</creationdate><title>Delivery strategies for antiparasitics</title><author>Kayser, Oliver ; Kiderlen, Albrecht F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-b306cfe516805b8cc96d83152a32c5a204e61f2849527d9649e1111acb3db823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Administration, Cutaneous</topic><topic>Administration, Oral</topic><topic>amphotericin B</topic><topic>Animals</topic><topic>Antiparasitic Agents - administration & dosage</topic><topic>colloidal carriers</topic><topic>Dosage Forms</topic><topic>drug delivery</topic><topic>Drug Delivery Systems - methods</topic><topic>Humans</topic><topic>leishmaniasis</topic><topic>liposomes</topic><topic>malaria</topic><topic>nanoparticles</topic><topic>parasites</topic><topic>Parasitic Diseases - drug therapy</topic><topic>Parasitic Diseases - parasitology</topic><topic>Pulmonary Alveoli - drug effects</topic><topic>Pulmonary Alveoli - parasitology</topic><topic>Schistosoma</topic><topic>surfactants</topic><topic>Trachea - drug effects</topic><topic>Trachea - parasitology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kayser, Oliver</creatorcontrib><creatorcontrib>Kiderlen, Albrecht F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Expert opinion on investigational drugs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kayser, Oliver</au><au>Kiderlen, Albrecht F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Delivery strategies for antiparasitics</atitle><jtitle>Expert opinion on investigational drugs</jtitle><addtitle>Expert Opin Investig Drugs</addtitle><date>2003-02-01</date><risdate>2003</risdate><volume>12</volume><issue>2</issue><spage>197</spage><epage>207</epage><pages>197-207</pages><issn>1354-3784</issn><eissn>1744-7658</eissn><abstract>Optimisation of drug carrier systems and drug delivery strategies that take into account the peculiarities of individual infectious agents and diseases are key elements of modern drug development. In the following, different aspects of a rational design for antiparasitic drug formulation will be reviewed, covering delivery systems such as nano- and microparticles, liposomes, emulsions and microemulsions, cochleates and bioadhesive macromolecules. Functional properties for each carrier system will be discussed as well as their therapeutic efficacy for parasitic diseases, including leishmaniasis, human African trypanosomiasis, human cryptosporidiosis, malaria and schistosomiasis. Critical issues for the application of drug carrier systems will be discussed, focusing on biopharmaceutical and pathophysiological parameters such as routes of application, improvement of body distribution and targeting intracellularly persisting pathogens.</abstract><cop>England</cop><pub>Ashley Publications Ltd</pub><pmid>12556214</pmid><doi>10.1517/13543784.12.2.197</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1354-3784 |
| ispartof | Expert opinion on investigational drugs, 2003-02, Vol.12 (2), p.197-207 |
| issn | 1354-3784 1744-7658 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_20375668 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Administration, Cutaneous Administration, Oral amphotericin B Animals Antiparasitic Agents - administration & dosage colloidal carriers Dosage Forms drug delivery Drug Delivery Systems - methods Humans leishmaniasis liposomes malaria nanoparticles parasites Parasitic Diseases - drug therapy Parasitic Diseases - parasitology Pulmonary Alveoli - drug effects Pulmonary Alveoli - parasitology Schistosoma surfactants Trachea - drug effects Trachea - parasitology |
| title | Delivery strategies for antiparasitics |
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