Suppression of mast cell-mediated allergic reaction by Amomum xanthiodes
The mast cell-mediated immediate-type allergic reaction is involved in many allergic diseases such as asthma, allergic rhinitis and sinusitis. Stimulation of mast cells starts the process of degranulation resulting in release of mediators such as histamine and an array of inflammatory cytokines. In...
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| Veröffentlicht in: | Food and chemical toxicology 2007-11, Vol.45 (11), p.2138-2144 |
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| creator | Kim, Sang-Hyun Lee, Soyoung Kim, In Kyeom Kwon, Taeg Kyu Moon, Jin-Young Park, Won-Hwan Shin, Tae-Yong |
| description | The mast cell-mediated immediate-type allergic reaction is involved in many allergic diseases such as asthma, allergic rhinitis and sinusitis. Stimulation of mast cells starts the process of degranulation resulting in release of mediators such as histamine and an array of inflammatory cytokines. In this report, we investigated the effect of aqueous extract of
Amomum xanthiodes (Zingiberaceae) (AXE) on the mast cell-mediated allergy model and studied its possible mechanisms of action. AXE inhibited compound 48/80-induced systemic reactions and serum histamine release in mice. AXE decreased immunoglobulin E (IgE)-mediated passive cutaneous anaphylaxis reaction. AXE reduced histamine release and intracellular calcium from rat peritoneal mast cells activated by compound 48/80. Furthermore, AXE decreased the activation of p38 mitogen-activated protein kinase (MAPK) but not extracellular signal-regulated kinase and
c-jun N-terminal kinase, and downstream tumor necrosis factor (TNF)-α production in phorbol 12-myristate 13-acetate and calcium ionophore A23187-stimulated human mast cells. Our findings provide evidence that AXE inhibits mast cell-derived allergic reactions, and that intracellular calcium, TNF-α, and p38 MAPK are involved in these effects. |
| doi_str_mv | 10.1016/j.fct.2007.05.011 |
| format | Article |
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Amomum xanthiodes (Zingiberaceae) (AXE) on the mast cell-mediated allergy model and studied its possible mechanisms of action. AXE inhibited compound 48/80-induced systemic reactions and serum histamine release in mice. AXE decreased immunoglobulin E (IgE)-mediated passive cutaneous anaphylaxis reaction. AXE reduced histamine release and intracellular calcium from rat peritoneal mast cells activated by compound 48/80. Furthermore, AXE decreased the activation of p38 mitogen-activated protein kinase (MAPK) but not extracellular signal-regulated kinase and
c-jun N-terminal kinase, and downstream tumor necrosis factor (TNF)-α production in phorbol 12-myristate 13-acetate and calcium ionophore A23187-stimulated human mast cells. Our findings provide evidence that AXE inhibits mast cell-derived allergic reactions, and that intracellular calcium, TNF-α, and p38 MAPK are involved in these effects.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2007.05.011</identifier><identifier>PMID: 17602813</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Amomum ; Amomum - chemistry ; Amomum xanthiodes ; Animals ; Anti-Allergic Agents - chemistry ; Anti-Allergic Agents - therapeutic use ; anti-inflammatory activity ; aqueous solutions ; Biological and medical sciences ; Calcimycin ; Calcium ; cell-mediated immunity ; Cells, Cultured ; cytokines ; Dose-Response Relationship, Drug ; Histamine ; humans ; Hypersensitivity - drug therapy ; immunoglobulin E ; immunostimulants ; Male ; Mast cell ; mast cells ; Mast Cells - drug effects ; Mast Cells - metabolism ; Medical sciences ; medicinal plants ; Mice ; Mice, Inbred ICR ; mitogen-activated protein kinase ; p-Methoxy-N-methylphenethylamine - adverse effects ; p38 MAPK ; p38 Mitogen-Activated Protein Kinases - genetics ; p38 Mitogen-Activated Protein Kinases - metabolism ; Phorbol Esters ; Phytotherapy ; plant extracts ; Plant Extracts - chemistry ; Plant Extracts - therapeutic use ; Rats ; Rats, Sprague-Dawley ; supercritical fluid extraction ; TNF-α ; Toxicology ; tumor necrosis factor-alpha ; Tumor Necrosis Factor-alpha - genetics ; Tumor Necrosis Factor-alpha - metabolism ; Zingiberaceae</subject><ispartof>Food and chemical toxicology, 2007-11, Vol.45 (11), p.2138-2144</ispartof><rights>2007 Elsevier Ltd</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-83ebeafdcbf18f542df08eda30e8e074e386abaa151da96bd32d14f7581b93a23</citedby><cites>FETCH-LOGICAL-c436t-83ebeafdcbf18f542df08eda30e8e074e386abaa151da96bd32d14f7581b93a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fct.2007.05.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19163394$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17602813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Sang-Hyun</creatorcontrib><creatorcontrib>Lee, Soyoung</creatorcontrib><creatorcontrib>Kim, In Kyeom</creatorcontrib><creatorcontrib>Kwon, Taeg Kyu</creatorcontrib><creatorcontrib>Moon, Jin-Young</creatorcontrib><creatorcontrib>Park, Won-Hwan</creatorcontrib><creatorcontrib>Shin, Tae-Yong</creatorcontrib><title>Suppression of mast cell-mediated allergic reaction by Amomum xanthiodes</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>The mast cell-mediated immediate-type allergic reaction is involved in many allergic diseases such as asthma, allergic rhinitis and sinusitis. Stimulation of mast cells starts the process of degranulation resulting in release of mediators such as histamine and an array of inflammatory cytokines. In this report, we investigated the effect of aqueous extract of
Amomum xanthiodes (Zingiberaceae) (AXE) on the mast cell-mediated allergy model and studied its possible mechanisms of action. AXE inhibited compound 48/80-induced systemic reactions and serum histamine release in mice. AXE decreased immunoglobulin E (IgE)-mediated passive cutaneous anaphylaxis reaction. AXE reduced histamine release and intracellular calcium from rat peritoneal mast cells activated by compound 48/80. Furthermore, AXE decreased the activation of p38 mitogen-activated protein kinase (MAPK) but not extracellular signal-regulated kinase and
c-jun N-terminal kinase, and downstream tumor necrosis factor (TNF)-α production in phorbol 12-myristate 13-acetate and calcium ionophore A23187-stimulated human mast cells. Our findings provide evidence that AXE inhibits mast cell-derived allergic reactions, and that intracellular calcium, TNF-α, and p38 MAPK are involved in these effects.</description><subject>Amomum</subject><subject>Amomum - chemistry</subject><subject>Amomum xanthiodes</subject><subject>Animals</subject><subject>Anti-Allergic Agents - chemistry</subject><subject>Anti-Allergic Agents - therapeutic use</subject><subject>anti-inflammatory activity</subject><subject>aqueous solutions</subject><subject>Biological and medical sciences</subject><subject>Calcimycin</subject><subject>Calcium</subject><subject>cell-mediated immunity</subject><subject>Cells, Cultured</subject><subject>cytokines</subject><subject>Dose-Response Relationship, Drug</subject><subject>Histamine</subject><subject>humans</subject><subject>Hypersensitivity - drug therapy</subject><subject>immunoglobulin E</subject><subject>immunostimulants</subject><subject>Male</subject><subject>Mast cell</subject><subject>mast cells</subject><subject>Mast Cells - drug effects</subject><subject>Mast Cells - metabolism</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>mitogen-activated protein kinase</subject><subject>p-Methoxy-N-methylphenethylamine - adverse effects</subject><subject>p38 MAPK</subject><subject>p38 Mitogen-Activated Protein Kinases - genetics</subject><subject>p38 Mitogen-Activated Protein Kinases - metabolism</subject><subject>Phorbol Esters</subject><subject>Phytotherapy</subject><subject>plant extracts</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - therapeutic use</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>supercritical fluid extraction</subject><subject>TNF-α</subject><subject>Toxicology</subject><subject>tumor necrosis factor-alpha</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Zingiberaceae</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90MFu1DAQgGELgehSeAAukAvcEjxx7DjiVFVAkSpxKD1bE3tcvErixU4QfXu82pV642JfvrHGP2NvgTfAQX3aN96uTct533DZcIBnbAe6F7USEp6zHW97XasB5AV7lfOeFwi9eskuyslbDWLHbu62wyFRziEuVfTVjHmtLE1TPZMLuJKrcJooPQRbJUK7Ht34WF3Ncd7m6i8u668QHeXX7IXHKdOb833J7r9--Xl9U9_--Pb9-uq2tp1Qa60FjYTe2dGD9rJrneeaHApOmnjfkdAKR0SQ4HBQoxOtg873UsM4CGzFJft4eveQ4u-N8mrmkI8L40Jxy6blopdS6wLhBG2KOSfy5pDCjOnRADfHfGZvSj5zzGe4NCVfmXl3fnwby_-fJs69CvhwBpgtTj7hYkN-cgMoIYauuPcn5zEafEjF3N-1HATnWsh2UEV8Pgkqsf4ESibbQIst1ROVtVwM_1n0H7WulyE</recordid><startdate>20071101</startdate><enddate>20071101</enddate><creator>Kim, Sang-Hyun</creator><creator>Lee, Soyoung</creator><creator>Kim, In Kyeom</creator><creator>Kwon, Taeg Kyu</creator><creator>Moon, Jin-Young</creator><creator>Park, Won-Hwan</creator><creator>Shin, Tae-Yong</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>20071101</creationdate><title>Suppression of mast cell-mediated allergic reaction by Amomum xanthiodes</title><author>Kim, Sang-Hyun ; Lee, Soyoung ; Kim, In Kyeom ; Kwon, Taeg Kyu ; Moon, Jin-Young ; Park, Won-Hwan ; Shin, Tae-Yong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-83ebeafdcbf18f542df08eda30e8e074e386abaa151da96bd32d14f7581b93a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Amomum</topic><topic>Amomum - chemistry</topic><topic>Amomum xanthiodes</topic><topic>Animals</topic><topic>Anti-Allergic Agents - chemistry</topic><topic>Anti-Allergic Agents - therapeutic use</topic><topic>anti-inflammatory activity</topic><topic>aqueous solutions</topic><topic>Biological and medical sciences</topic><topic>Calcimycin</topic><topic>Calcium</topic><topic>cell-mediated immunity</topic><topic>Cells, Cultured</topic><topic>cytokines</topic><topic>Dose-Response Relationship, Drug</topic><topic>Histamine</topic><topic>humans</topic><topic>Hypersensitivity - drug therapy</topic><topic>immunoglobulin E</topic><topic>immunostimulants</topic><topic>Male</topic><topic>Mast cell</topic><topic>mast cells</topic><topic>Mast Cells - drug effects</topic><topic>Mast Cells - metabolism</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>mitogen-activated protein kinase</topic><topic>p-Methoxy-N-methylphenethylamine - adverse effects</topic><topic>p38 MAPK</topic><topic>p38 Mitogen-Activated Protein Kinases - genetics</topic><topic>p38 Mitogen-Activated Protein Kinases - metabolism</topic><topic>Phorbol Esters</topic><topic>Phytotherapy</topic><topic>plant extracts</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - therapeutic use</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>supercritical fluid extraction</topic><topic>TNF-α</topic><topic>Toxicology</topic><topic>tumor necrosis factor-alpha</topic><topic>Tumor Necrosis Factor-alpha - genetics</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Zingiberaceae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Sang-Hyun</creatorcontrib><creatorcontrib>Lee, Soyoung</creatorcontrib><creatorcontrib>Kim, In Kyeom</creatorcontrib><creatorcontrib>Kwon, Taeg Kyu</creatorcontrib><creatorcontrib>Moon, Jin-Young</creatorcontrib><creatorcontrib>Park, Won-Hwan</creatorcontrib><creatorcontrib>Shin, Tae-Yong</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Sang-Hyun</au><au>Lee, Soyoung</au><au>Kim, In Kyeom</au><au>Kwon, Taeg Kyu</au><au>Moon, Jin-Young</au><au>Park, Won-Hwan</au><au>Shin, Tae-Yong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suppression of mast cell-mediated allergic reaction by Amomum xanthiodes</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2007-11-01</date><risdate>2007</risdate><volume>45</volume><issue>11</issue><spage>2138</spage><epage>2144</epage><pages>2138-2144</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>The mast cell-mediated immediate-type allergic reaction is involved in many allergic diseases such as asthma, allergic rhinitis and sinusitis. Stimulation of mast cells starts the process of degranulation resulting in release of mediators such as histamine and an array of inflammatory cytokines. In this report, we investigated the effect of aqueous extract of
Amomum xanthiodes (Zingiberaceae) (AXE) on the mast cell-mediated allergy model and studied its possible mechanisms of action. AXE inhibited compound 48/80-induced systemic reactions and serum histamine release in mice. AXE decreased immunoglobulin E (IgE)-mediated passive cutaneous anaphylaxis reaction. AXE reduced histamine release and intracellular calcium from rat peritoneal mast cells activated by compound 48/80. Furthermore, AXE decreased the activation of p38 mitogen-activated protein kinase (MAPK) but not extracellular signal-regulated kinase and
c-jun N-terminal kinase, and downstream tumor necrosis factor (TNF)-α production in phorbol 12-myristate 13-acetate and calcium ionophore A23187-stimulated human mast cells. Our findings provide evidence that AXE inhibits mast cell-derived allergic reactions, and that intracellular calcium, TNF-α, and p38 MAPK are involved in these effects.</abstract><cop>Oxford</cop><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>17602813</pmid><doi>10.1016/j.fct.2007.05.011</doi><tpages>7</tpages></addata></record> |
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| subjects | Amomum Amomum - chemistry Amomum xanthiodes Animals Anti-Allergic Agents - chemistry Anti-Allergic Agents - therapeutic use anti-inflammatory activity aqueous solutions Biological and medical sciences Calcimycin Calcium cell-mediated immunity Cells, Cultured cytokines Dose-Response Relationship, Drug Histamine humans Hypersensitivity - drug therapy immunoglobulin E immunostimulants Male Mast cell mast cells Mast Cells - drug effects Mast Cells - metabolism Medical sciences medicinal plants Mice Mice, Inbred ICR mitogen-activated protein kinase p-Methoxy-N-methylphenethylamine - adverse effects p38 MAPK p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - metabolism Phorbol Esters Phytotherapy plant extracts Plant Extracts - chemistry Plant Extracts - therapeutic use Rats Rats, Sprague-Dawley supercritical fluid extraction TNF-α Toxicology tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Zingiberaceae |
| title | Suppression of mast cell-mediated allergic reaction by Amomum xanthiodes |
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