Synthesis and characterization of PEG-PCL-PEG thermosensitive hydrogel

In this work, a series of biodegradable triblock poly(ethylene glycol)-poly(ɛ-caprolactone)-poly(ethylene glycol) (PEG-PCL-PEG, PECE) copolymers were successfully synthesized by ring-opening copolymerization, and were characterized by 1H NMR, FT-IR, GPC, and DSC. Aqueous solutions of PECE copolymers...

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Veröffentlicht in:	International journal of pharmaceutics 2009-01, Vol.365 (1), p.89-99
Hauptverfasser:	Gong, ChangYang, Shi, Shuai, Dong, PengWei, Kan, Bing, Gou, MaLing, Wang, XianHuo, Li, XingYi, Luo, Feng, Zhao, Xia, Wei, YuQuan, Qian, ZhiYong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biodegradable Biological and medical sciences Cell Line Degradation Delayed-Action Preparations Drug Delivery Systems General pharmacology Humans Hydrogels Hydrophobic and Hydrophilic Interactions In vitro drug release Injections, Subcutaneous Medical sciences Mice Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Phase Transition Polyesters - chemical synthesis Polyesters - chemistry Polyesters - toxicity Polyethylene Glycols - chemical synthesis Polyethylene Glycols - chemistry Polyethylene Glycols - toxicity Sol–gel–sol transition Temperature Thermosensitive hydrogel Toxicity Tests
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