In Vitro and in Vivo Antitrypanosomal Activitiy of Two Microbial Metabolites, KS-505a and Alazopeptin
Our on-going screening program to discover new antitrypanosomal antibiotics has been evaluating compounds isolated from soil microorganisms as well as investigating the antibiotic libraries of the Kitasato Institute for Life Sciences and BioFrontier Laboratories of Kyowa Hakko Kogyo Co., Ltd. We hav...
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| Veröffentlicht in: | Journal of antibiotics 2008-10, Vol.61 (10), p.627-632 |
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| container_title | Journal of antibiotics |
| container_volume | 61 |
| creator | Ishiyama, Aki Otoguro, Kazuhiko Namatame, Miyuki Nishihara, Aki Furusawa, Toshiaki Masuma, Rokuro Shiomi, Kazuro Takahashi, Yoko Ichimura, Michio Yamada, Haruki Ōmura, Satoshi |
| description | Our on-going screening program to discover new antitrypanosomal antibiotics has been evaluating compounds isolated from soil microorganisms as well as investigating the antibiotic libraries of the Kitasato Institute for Life Sciences and BioFrontier Laboratories of Kyowa Hakko Kogyo Co., Ltd. We have now discovered two compounds, KS-505a and alazopeptin, which exhibit moderate antitrypanosomal characteristics. We report here the
in vitro
and
in vivo
antitrypanosomal activities and cytotoxicities of KS-505a and alazopeptin, compared with some commonly-used antitrypanosomal drugs. This is the first report of
in vitro
and
in vivo
antitrypanosomal activities of either KS-505a or alazopeptin. |
| doi_str_mv | 10.1038/ja.2008.83 |
| format | Article |
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in vitro
and
in vivo
antitrypanosomal activities and cytotoxicities of KS-505a and alazopeptin, compared with some commonly-used antitrypanosomal drugs. This is the first report of
in vitro
and
in vivo
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in vitro
and
in vivo
antitrypanosomal activities and cytotoxicities of KS-505a and alazopeptin, compared with some commonly-used antitrypanosomal drugs. This is the first report of
in vitro
and
in vivo
antitrypanosomal activities of either KS-505a or alazopeptin.</description><subject>Animals</subject><subject>Antibiotics</subject><subject>Bacteriology</subject><subject>Biomedical and Life Sciences</subject><subject>Bioorganic Chemistry</subject><subject>Cell Line</subject><subject>Dipeptides - chemistry</subject><subject>Dipeptides - pharmacology</subject><subject>Dipeptides - toxicity</subject><subject>Drug Discovery</subject><subject>Female</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Life Sciences</subject><subject>Medicinal Chemistry</subject><subject>Metabolites</subject><subject>Methylglucosides - chemistry</subject><subject>Methylglucosides - pharmacology</subject><subject>Methylglucosides - toxicity</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Microbiology</subject><subject>Microorganisms</subject><subject>Molecular Structure</subject><subject>Organic Chemistry</subject><subject>original-article</subject><subject>Parasitic Sensitivity Tests</subject><subject>Soil Microbiology</subject><subject>Soil microorganisms</subject><subject>Terpenes - 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We have now discovered two compounds, KS-505a and alazopeptin, which exhibit moderate antitrypanosomal characteristics. We report here the
in vitro
and
in vivo
antitrypanosomal activities and cytotoxicities of KS-505a and alazopeptin, compared with some commonly-used antitrypanosomal drugs. This is the first report of
in vitro
and
in vivo
antitrypanosomal activities of either KS-505a or alazopeptin.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>19168977</pmid><doi>10.1038/ja.2008.83</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of antibiotics, 2008-10, Vol.61 (10), p.627-632 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Antibiotics Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Cell Line Dipeptides - chemistry Dipeptides - pharmacology Dipeptides - toxicity Drug Discovery Female Humans In Vitro Techniques Life Sciences Medicinal Chemistry Metabolites Methylglucosides - chemistry Methylglucosides - pharmacology Methylglucosides - toxicity Mice Mice, Inbred ICR Microbiology Microorganisms Molecular Structure Organic Chemistry original-article Parasitic Sensitivity Tests Soil Microbiology Soil microorganisms Terpenes - chemistry Terpenes - pharmacology Terpenes - toxicity Trypanocidal Agents - chemistry Trypanocidal Agents - pharmacology Trypanocidal Agents - toxicity Trypanosoma brucei brucei - drug effects Trypanosoma brucei rhodesiense - drug effects Trypanosomiasis, African - drug therapy |
| title | In Vitro and in Vivo Antitrypanosomal Activitiy of Two Microbial Metabolites, KS-505a and Alazopeptin |
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