Dysregulation of EZH2/miR-138 axis contributes to drug resistance in multiple myeloma by downregulating RBPMS

EZH2 is highly expressed in multiple myeloma (MM). However, the molecular mechanisms underlying EZH2 overexpression and its role in drug resistance of MM remain undefined. Here we show that EZH2 is upregulated in drug-resistant MM cells and its aberrant overexpression is associated with poor prognos...

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Veröffentlicht in:	Leukemia 2018-11, Vol.32 (11), p.2471-2482
Hauptverfasser:	Rastgoo, Nasrin, Pourabdollah, Maryam, Abdi, Jahangir, Reece, Donna, Chang, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/109 13/31 13/51 13/89 38/22 38/43 38/47 38/77 631/208/68/2486 692/420/755 Algorithms Bortezomib Cancer Research Critical Care Medicine Displays (Marketing) Dosage and administration Drug delivery systems Drug development Drug resistance Drug therapy Gene expression Genetic aspects Health aspects Hematology Inhibitors Intensive Internal Medicine Medicine Medicine & Public Health Methylation MicroRNA miRNA Molecular modelling Multiple myeloma Oncology Pharmacology Proteasome inhibitors Regression analysis Restoration Target recognition Therapeutic applications Tumor cell lines Tumor cells Tumors Xenografts Xenotransplantation
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