The novel cutoff points for the FIB4 index categorized by age increase the diagnostic accuracy in NAFLD: a multi-center study
Background The FIB4 index is clinically useful, but because its formula includes age, the appropriate cutoff point may differ by age group. Here, new FIB4 index cutoff points were validated using cohort data from 14 hepatology centers in Japan. Methods The FIB4 index was determined in biopsy-confirm...
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| Veröffentlicht in: | Journal of gastroenterology 2018-11, Vol.53 (11), p.1216-1224 |
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| creator | Ishiba, Hiroshi Sumida, Yoshio Tanaka, Saiyu Yoneda, Masato Hyogo, Hideyuki Ono, Masafumi Fujii, Hideki Eguchi, Yuichiro Suzuki, Yasuaki Yoneda, Masashi Takahashi, Hirokazu Nakahara, Takashi Seko, Yuya Mori, Kojiro Kanemasa, Kazuyuki Shimada, Keiji Imai, Sunsuke Imajo, Kento Kawaguchi, Takumi Nakajima, Atsushi Chayama, Kazuaki Saibara, Toshiji Shima, Toshihide Fujimoto, Kazuma Okanoue, Takeshi Itoh, Yoshito |
| description | Background
The FIB4 index is clinically useful, but because its formula includes age, the appropriate cutoff point may differ by age group. Here, new FIB4 index cutoff points were validated using cohort data from 14 hepatology centers in Japan.
Methods
The FIB4 index was determined in biopsy-confirmed NAFLD patients (
n
= 1050) who were divided into four groups: ≤ 49, 50–59, 60–69, and ≥ 70 years. ROC analysis predicted advanced fibrosis in each age group; low and high cutoff points were defined by a sensitivity and specificity of 90%. The new and conventional cutoffs were compared for detecting advanced fibrosis.
Results
The modified low and high cutoff points were 1.05 and 1.21 in ≤ 49 years, 1.24 and 1.96 in 50–59 years, 1.88 and 3.24 in 60–69 years, and 1.95 and 4.56 in ≥ 70 years. In ≥ 60 years, the false-negative rate was increased using the modified high cutoff point, and the high cutoff point was better with the conventional cutoff point. The new proposed low and high cutoff points are 1.05 and 1.21 in ≤ 49 years, 1.24 and 1.96 in 50–59 years, 1.88 and 2.67 in 60–69 years, and 1.95 and 2.67 in ≥ 70 years; these cutoff points improved the accuracy of advanced fibrosis diagnosis.
Conclusions
FIB4 index cutoff points for predicting advanced fibrosis in NAFLD increased with age. Cutoff points modified by age improved the diagnostic accuracy of estimations of advanced liver fibrosis using the FIB4 index. |
| doi_str_mv | 10.1007/s00535-018-1474-y |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2037055793</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A714583125</galeid><sourcerecordid>A714583125</sourcerecordid><originalsourceid>FETCH-LOGICAL-c613t-44698b7f4f5712154e845a586e463783ad6fad4041e63f1bcbc252dfef64453c3</originalsourceid><addsrcrecordid>eNp1kUtv1DAUhSMEokPhB7BBltiwSfEzTthNWwYqjWBT1pbjXAdXGXuwHUSQ-t_xMIUKBPLC0j3fuQ-dqnpO8BnBWL5OGAsmakzamnDJ6-VBtSK8VERH6cNqhTvOa0IkP6mepHSDMWFYtI-rE9pJzkUnV9Xt9WdAPnyFCZk5B2vRPjifE7Iholy0zdU5R84P8A0ZnWEM0X2HAfUL0iMUwUTQCX6ig9OjDyk7g7Qxc9RmKQD6sN5sL98gjXbzlF1twGeIKOV5WJ5Wj6yeEjy7-0-rT5u31xfv6-3Hd1cX621tGsJyzXnTtb203ApJKBEcWi60aBvgDZMt00Nj9cAxJ9AwS3rTGyroYME25Uxm2Gn16th3H8OXGVJWO5cMTJP2EOakKGYSCyE7VtCXf6E3YY6-bHegmjKUtu09NeoJlPM25HLuoalaS8JFywgVhTr7B1XeADtnggfrSv0PAzkaTAwpRbBqH91Ox0URrA6Rq2PkqkSuDpGrpXhe3C089zsYfjt-ZVwAegRSkfwI8f6i_3f9ARNPtHY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2036586288</pqid></control><display><type>article</type><title>The novel cutoff points for the FIB4 index categorized by age increase the diagnostic accuracy in NAFLD: a multi-center study</title><source>Springer Nature - Complete Springer Journals</source><creator>Ishiba, Hiroshi ; Sumida, Yoshio ; Tanaka, Saiyu ; Yoneda, Masato ; Hyogo, Hideyuki ; Ono, Masafumi ; Fujii, Hideki ; Eguchi, Yuichiro ; Suzuki, Yasuaki ; Yoneda, Masashi ; Takahashi, Hirokazu ; Nakahara, Takashi ; Seko, Yuya ; Mori, Kojiro ; Kanemasa, Kazuyuki ; Shimada, Keiji ; Imai, Sunsuke ; Imajo, Kento ; Kawaguchi, Takumi ; Nakajima, Atsushi ; Chayama, Kazuaki ; Saibara, Toshiji ; Shima, Toshihide ; Fujimoto, Kazuma ; Okanoue, Takeshi ; Itoh, Yoshito</creator><creatorcontrib>Ishiba, Hiroshi ; Sumida, Yoshio ; Tanaka, Saiyu ; Yoneda, Masato ; Hyogo, Hideyuki ; Ono, Masafumi ; Fujii, Hideki ; Eguchi, Yuichiro ; Suzuki, Yasuaki ; Yoneda, Masashi ; Takahashi, Hirokazu ; Nakahara, Takashi ; Seko, Yuya ; Mori, Kojiro ; Kanemasa, Kazuyuki ; Shimada, Keiji ; Imai, Sunsuke ; Imajo, Kento ; Kawaguchi, Takumi ; Nakajima, Atsushi ; Chayama, Kazuaki ; Saibara, Toshiji ; Shima, Toshihide ; Fujimoto, Kazuma ; Okanoue, Takeshi ; Itoh, Yoshito ; Japan Study Group of Non-Alcoholic Fatty Liver Disease (JSG-NAFLD) ; for the Japan Study Group of Non-Alcoholic Fatty Liver Disease (JSG-NAFLD)</creatorcontrib><description>Background
The FIB4 index is clinically useful, but because its formula includes age, the appropriate cutoff point may differ by age group. Here, new FIB4 index cutoff points were validated using cohort data from 14 hepatology centers in Japan.
Methods
The FIB4 index was determined in biopsy-confirmed NAFLD patients (
n
= 1050) who were divided into four groups: ≤ 49, 50–59, 60–69, and ≥ 70 years. ROC analysis predicted advanced fibrosis in each age group; low and high cutoff points were defined by a sensitivity and specificity of 90%. The new and conventional cutoffs were compared for detecting advanced fibrosis.
Results
The modified low and high cutoff points were 1.05 and 1.21 in ≤ 49 years, 1.24 and 1.96 in 50–59 years, 1.88 and 3.24 in 60–69 years, and 1.95 and 4.56 in ≥ 70 years. In ≥ 60 years, the false-negative rate was increased using the modified high cutoff point, and the high cutoff point was better with the conventional cutoff point. The new proposed low and high cutoff points are 1.05 and 1.21 in ≤ 49 years, 1.24 and 1.96 in 50–59 years, 1.88 and 2.67 in 60–69 years, and 1.95 and 2.67 in ≥ 70 years; these cutoff points improved the accuracy of advanced fibrosis diagnosis.
Conclusions
FIB4 index cutoff points for predicting advanced fibrosis in NAFLD increased with age. Cutoff points modified by age improved the diagnostic accuracy of estimations of advanced liver fibrosis using the FIB4 index.</description><identifier>ISSN: 0944-1174</identifier><identifier>EISSN: 1435-5922</identifier><identifier>DOI: 10.1007/s00535-018-1474-y</identifier><identifier>PMID: 29744597</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Abdominal Surgery ; Academic grading ; Accuracy ; Achievement tests ; Age ; Analysis ; Biliary Tract ; Biopsy ; Colorectal Surgery ; Fibrosis ; Gastroenterology ; Hepatology ; Intelligence tests ; Liver ; Liver diseases ; Medical diagnosis ; Medicine ; Medicine & Public Health ; Middle school students ; Original Article—Liver ; Pancreas ; Surgical Oncology</subject><ispartof>Journal of gastroenterology, 2018-11, Vol.53 (11), p.1216-1224</ispartof><rights>Japanese Society of Gastroenterology 2018</rights><rights>COPYRIGHT 2018 Springer</rights><rights>Journal of Gastroenterology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c613t-44698b7f4f5712154e845a586e463783ad6fad4041e63f1bcbc252dfef64453c3</citedby><cites>FETCH-LOGICAL-c613t-44698b7f4f5712154e845a586e463783ad6fad4041e63f1bcbc252dfef64453c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00535-018-1474-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00535-018-1474-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29744597$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishiba, Hiroshi</creatorcontrib><creatorcontrib>Sumida, Yoshio</creatorcontrib><creatorcontrib>Tanaka, Saiyu</creatorcontrib><creatorcontrib>Yoneda, Masato</creatorcontrib><creatorcontrib>Hyogo, Hideyuki</creatorcontrib><creatorcontrib>Ono, Masafumi</creatorcontrib><creatorcontrib>Fujii, Hideki</creatorcontrib><creatorcontrib>Eguchi, Yuichiro</creatorcontrib><creatorcontrib>Suzuki, Yasuaki</creatorcontrib><creatorcontrib>Yoneda, Masashi</creatorcontrib><creatorcontrib>Takahashi, Hirokazu</creatorcontrib><creatorcontrib>Nakahara, Takashi</creatorcontrib><creatorcontrib>Seko, Yuya</creatorcontrib><creatorcontrib>Mori, Kojiro</creatorcontrib><creatorcontrib>Kanemasa, Kazuyuki</creatorcontrib><creatorcontrib>Shimada, Keiji</creatorcontrib><creatorcontrib>Imai, Sunsuke</creatorcontrib><creatorcontrib>Imajo, Kento</creatorcontrib><creatorcontrib>Kawaguchi, Takumi</creatorcontrib><creatorcontrib>Nakajima, Atsushi</creatorcontrib><creatorcontrib>Chayama, Kazuaki</creatorcontrib><creatorcontrib>Saibara, Toshiji</creatorcontrib><creatorcontrib>Shima, Toshihide</creatorcontrib><creatorcontrib>Fujimoto, Kazuma</creatorcontrib><creatorcontrib>Okanoue, Takeshi</creatorcontrib><creatorcontrib>Itoh, Yoshito</creatorcontrib><creatorcontrib>Japan Study Group of Non-Alcoholic Fatty Liver Disease (JSG-NAFLD)</creatorcontrib><creatorcontrib>for the Japan Study Group of Non-Alcoholic Fatty Liver Disease (JSG-NAFLD)</creatorcontrib><title>The novel cutoff points for the FIB4 index categorized by age increase the diagnostic accuracy in NAFLD: a multi-center study</title><title>Journal of gastroenterology</title><addtitle>J Gastroenterol</addtitle><addtitle>J Gastroenterol</addtitle><description>Background
The FIB4 index is clinically useful, but because its formula includes age, the appropriate cutoff point may differ by age group. Here, new FIB4 index cutoff points were validated using cohort data from 14 hepatology centers in Japan.
Methods
The FIB4 index was determined in biopsy-confirmed NAFLD patients (
n
= 1050) who were divided into four groups: ≤ 49, 50–59, 60–69, and ≥ 70 years. ROC analysis predicted advanced fibrosis in each age group; low and high cutoff points were defined by a sensitivity and specificity of 90%. The new and conventional cutoffs were compared for detecting advanced fibrosis.
Results
The modified low and high cutoff points were 1.05 and 1.21 in ≤ 49 years, 1.24 and 1.96 in 50–59 years, 1.88 and 3.24 in 60–69 years, and 1.95 and 4.56 in ≥ 70 years. In ≥ 60 years, the false-negative rate was increased using the modified high cutoff point, and the high cutoff point was better with the conventional cutoff point. The new proposed low and high cutoff points are 1.05 and 1.21 in ≤ 49 years, 1.24 and 1.96 in 50–59 years, 1.88 and 2.67 in 60–69 years, and 1.95 and 2.67 in ≥ 70 years; these cutoff points improved the accuracy of advanced fibrosis diagnosis.
Conclusions
FIB4 index cutoff points for predicting advanced fibrosis in NAFLD increased with age. Cutoff points modified by age improved the diagnostic accuracy of estimations of advanced liver fibrosis using the FIB4 index.</description><subject>Abdominal Surgery</subject><subject>Academic grading</subject><subject>Accuracy</subject><subject>Achievement tests</subject><subject>Age</subject><subject>Analysis</subject><subject>Biliary Tract</subject><subject>Biopsy</subject><subject>Colorectal Surgery</subject><subject>Fibrosis</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Intelligence tests</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>Medical diagnosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle school students</subject><subject>Original Article—Liver</subject><subject>Pancreas</subject><subject>Surgical Oncology</subject><issn>0944-1174</issn><issn>1435-5922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kUtv1DAUhSMEokPhB7BBltiwSfEzTthNWwYqjWBT1pbjXAdXGXuwHUSQ-t_xMIUKBPLC0j3fuQ-dqnpO8BnBWL5OGAsmakzamnDJ6-VBtSK8VERH6cNqhTvOa0IkP6mepHSDMWFYtI-rE9pJzkUnV9Xt9WdAPnyFCZk5B2vRPjifE7Iholy0zdU5R84P8A0ZnWEM0X2HAfUL0iMUwUTQCX6ig9OjDyk7g7Qxc9RmKQD6sN5sL98gjXbzlF1twGeIKOV5WJ5Wj6yeEjy7-0-rT5u31xfv6-3Hd1cX621tGsJyzXnTtb203ApJKBEcWi60aBvgDZMt00Nj9cAxJ9AwS3rTGyroYME25Uxm2Gn16th3H8OXGVJWO5cMTJP2EOakKGYSCyE7VtCXf6E3YY6-bHegmjKUtu09NeoJlPM25HLuoalaS8JFywgVhTr7B1XeADtnggfrSv0PAzkaTAwpRbBqH91Ox0URrA6Rq2PkqkSuDpGrpXhe3C089zsYfjt-ZVwAegRSkfwI8f6i_3f9ARNPtHY</recordid><startdate>20181101</startdate><enddate>20181101</enddate><creator>Ishiba, Hiroshi</creator><creator>Sumida, Yoshio</creator><creator>Tanaka, Saiyu</creator><creator>Yoneda, Masato</creator><creator>Hyogo, Hideyuki</creator><creator>Ono, Masafumi</creator><creator>Fujii, Hideki</creator><creator>Eguchi, Yuichiro</creator><creator>Suzuki, Yasuaki</creator><creator>Yoneda, Masashi</creator><creator>Takahashi, Hirokazu</creator><creator>Nakahara, Takashi</creator><creator>Seko, Yuya</creator><creator>Mori, Kojiro</creator><creator>Kanemasa, Kazuyuki</creator><creator>Shimada, Keiji</creator><creator>Imai, Sunsuke</creator><creator>Imajo, Kento</creator><creator>Kawaguchi, Takumi</creator><creator>Nakajima, Atsushi</creator><creator>Chayama, Kazuaki</creator><creator>Saibara, Toshiji</creator><creator>Shima, Toshihide</creator><creator>Fujimoto, Kazuma</creator><creator>Okanoue, Takeshi</creator><creator>Itoh, Yoshito</creator><general>Springer Japan</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20181101</creationdate><title>The novel cutoff points for the FIB4 index categorized by age increase the diagnostic accuracy in NAFLD: a multi-center study</title><author>Ishiba, Hiroshi ; Sumida, Yoshio ; Tanaka, Saiyu ; Yoneda, Masato ; Hyogo, Hideyuki ; Ono, Masafumi ; Fujii, Hideki ; Eguchi, Yuichiro ; Suzuki, Yasuaki ; Yoneda, Masashi ; Takahashi, Hirokazu ; Nakahara, Takashi ; Seko, Yuya ; Mori, Kojiro ; Kanemasa, Kazuyuki ; Shimada, Keiji ; Imai, Sunsuke ; Imajo, Kento ; Kawaguchi, Takumi ; Nakajima, Atsushi ; Chayama, Kazuaki ; Saibara, Toshiji ; Shima, Toshihide ; Fujimoto, Kazuma ; Okanoue, Takeshi ; Itoh, Yoshito</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c613t-44698b7f4f5712154e845a586e463783ad6fad4041e63f1bcbc252dfef64453c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Abdominal Surgery</topic><topic>Academic grading</topic><topic>Accuracy</topic><topic>Achievement tests</topic><topic>Age</topic><topic>Analysis</topic><topic>Biliary Tract</topic><topic>Biopsy</topic><topic>Colorectal Surgery</topic><topic>Fibrosis</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Intelligence tests</topic><topic>Liver</topic><topic>Liver diseases</topic><topic>Medical diagnosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle school students</topic><topic>Original Article—Liver</topic><topic>Pancreas</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishiba, Hiroshi</creatorcontrib><creatorcontrib>Sumida, Yoshio</creatorcontrib><creatorcontrib>Tanaka, Saiyu</creatorcontrib><creatorcontrib>Yoneda, Masato</creatorcontrib><creatorcontrib>Hyogo, Hideyuki</creatorcontrib><creatorcontrib>Ono, Masafumi</creatorcontrib><creatorcontrib>Fujii, Hideki</creatorcontrib><creatorcontrib>Eguchi, Yuichiro</creatorcontrib><creatorcontrib>Suzuki, Yasuaki</creatorcontrib><creatorcontrib>Yoneda, Masashi</creatorcontrib><creatorcontrib>Takahashi, Hirokazu</creatorcontrib><creatorcontrib>Nakahara, Takashi</creatorcontrib><creatorcontrib>Seko, Yuya</creatorcontrib><creatorcontrib>Mori, Kojiro</creatorcontrib><creatorcontrib>Kanemasa, Kazuyuki</creatorcontrib><creatorcontrib>Shimada, Keiji</creatorcontrib><creatorcontrib>Imai, Sunsuke</creatorcontrib><creatorcontrib>Imajo, Kento</creatorcontrib><creatorcontrib>Kawaguchi, Takumi</creatorcontrib><creatorcontrib>Nakajima, Atsushi</creatorcontrib><creatorcontrib>Chayama, Kazuaki</creatorcontrib><creatorcontrib>Saibara, Toshiji</creatorcontrib><creatorcontrib>Shima, Toshihide</creatorcontrib><creatorcontrib>Fujimoto, Kazuma</creatorcontrib><creatorcontrib>Okanoue, Takeshi</creatorcontrib><creatorcontrib>Itoh, Yoshito</creatorcontrib><creatorcontrib>Japan Study Group of Non-Alcoholic Fatty Liver Disease (JSG-NAFLD)</creatorcontrib><creatorcontrib>for the Japan Study Group of Non-Alcoholic Fatty Liver Disease (JSG-NAFLD)</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishiba, Hiroshi</au><au>Sumida, Yoshio</au><au>Tanaka, Saiyu</au><au>Yoneda, Masato</au><au>Hyogo, Hideyuki</au><au>Ono, Masafumi</au><au>Fujii, Hideki</au><au>Eguchi, Yuichiro</au><au>Suzuki, Yasuaki</au><au>Yoneda, Masashi</au><au>Takahashi, Hirokazu</au><au>Nakahara, Takashi</au><au>Seko, Yuya</au><au>Mori, Kojiro</au><au>Kanemasa, Kazuyuki</au><au>Shimada, Keiji</au><au>Imai, Sunsuke</au><au>Imajo, Kento</au><au>Kawaguchi, Takumi</au><au>Nakajima, Atsushi</au><au>Chayama, Kazuaki</au><au>Saibara, Toshiji</au><au>Shima, Toshihide</au><au>Fujimoto, Kazuma</au><au>Okanoue, Takeshi</au><au>Itoh, Yoshito</au><aucorp>Japan Study Group of Non-Alcoholic Fatty Liver Disease (JSG-NAFLD)</aucorp><aucorp>for the Japan Study Group of Non-Alcoholic Fatty Liver Disease (JSG-NAFLD)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The novel cutoff points for the FIB4 index categorized by age increase the diagnostic accuracy in NAFLD: a multi-center study</atitle><jtitle>Journal of gastroenterology</jtitle><stitle>J Gastroenterol</stitle><addtitle>J Gastroenterol</addtitle><date>2018-11-01</date><risdate>2018</risdate><volume>53</volume><issue>11</issue><spage>1216</spage><epage>1224</epage><pages>1216-1224</pages><issn>0944-1174</issn><eissn>1435-5922</eissn><abstract>Background
The FIB4 index is clinically useful, but because its formula includes age, the appropriate cutoff point may differ by age group. Here, new FIB4 index cutoff points were validated using cohort data from 14 hepatology centers in Japan.
Methods
The FIB4 index was determined in biopsy-confirmed NAFLD patients (
n
= 1050) who were divided into four groups: ≤ 49, 50–59, 60–69, and ≥ 70 years. ROC analysis predicted advanced fibrosis in each age group; low and high cutoff points were defined by a sensitivity and specificity of 90%. The new and conventional cutoffs were compared for detecting advanced fibrosis.
Results
The modified low and high cutoff points were 1.05 and 1.21 in ≤ 49 years, 1.24 and 1.96 in 50–59 years, 1.88 and 3.24 in 60–69 years, and 1.95 and 4.56 in ≥ 70 years. In ≥ 60 years, the false-negative rate was increased using the modified high cutoff point, and the high cutoff point was better with the conventional cutoff point. The new proposed low and high cutoff points are 1.05 and 1.21 in ≤ 49 years, 1.24 and 1.96 in 50–59 years, 1.88 and 2.67 in 60–69 years, and 1.95 and 2.67 in ≥ 70 years; these cutoff points improved the accuracy of advanced fibrosis diagnosis.
Conclusions
FIB4 index cutoff points for predicting advanced fibrosis in NAFLD increased with age. Cutoff points modified by age improved the diagnostic accuracy of estimations of advanced liver fibrosis using the FIB4 index.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>29744597</pmid><doi>10.1007/s00535-018-1474-y</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-1174 |
| ispartof | Journal of gastroenterology, 2018-11, Vol.53 (11), p.1216-1224 |
| issn | 0944-1174 1435-5922 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2037055793 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Abdominal Surgery Academic grading Accuracy Achievement tests Age Analysis Biliary Tract Biopsy Colorectal Surgery Fibrosis Gastroenterology Hepatology Intelligence tests Liver Liver diseases Medical diagnosis Medicine Medicine & Public Health Middle school students Original Article—Liver Pancreas Surgical Oncology |
| title | The novel cutoff points for the FIB4 index categorized by age increase the diagnostic accuracy in NAFLD: a multi-center study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T10%3A38%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20novel%20cutoff%20points%20for%20the%20FIB4%20index%20categorized%20by%20age%20increase%20the%20diagnostic%20accuracy%20in%20NAFLD:%20a%20multi-center%20study&rft.jtitle=Journal%20of%20gastroenterology&rft.au=Ishiba,%20Hiroshi&rft.aucorp=Japan%20Study%20Group%20of%20Non-Alcoholic%20Fatty%20Liver%20Disease%20(JSG-NAFLD)&rft.date=2018-11-01&rft.volume=53&rft.issue=11&rft.spage=1216&rft.epage=1224&rft.pages=1216-1224&rft.issn=0944-1174&rft.eissn=1435-5922&rft_id=info:doi/10.1007/s00535-018-1474-y&rft_dat=%3Cgale_proqu%3EA714583125%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2036586288&rft_id=info:pmid/29744597&rft_galeid=A714583125&rfr_iscdi=true |