Walnut phenolic extract inhibits nuclear factor kappaB signaling in intestinal epithelial cells, and ameliorates experimental colitis and colitis-associated colon cancer in mice

Purpose Walnuts (Juglans regia) are known to have anti-cancer and immunomodulatory effects. However, little information is available on the effects of walnut phenolic extract (WPE) on intestinal inflammation and colitis-associated colon cancer. Methods COLO205 cells were pretreated with WPE and then...

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Veröffentlicht in:	European journal of nutrition 2019-06, Vol.58 (4), p.1603-1613
Hauptverfasser:	Koh, Seong-Joon, Choi, Youn-I, Kim, Yuri, Kim, Yoo-Sun, Choi, Sang Woon, Kim, Ji Won, Kim, Byeong Gwan, Lee, Kook Lae
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Azoxymethane Chemistry Chemistry and Materials Science Colitis Colitis - drug therapy Colitis - metabolism Colon cancer Colonic Diseases - drug therapy Colonic Diseases - metabolism Colonic Neoplasms - drug therapy Colonic Neoplasms - metabolism Colorectal cancer Deoxyribonucleic acid Dextran Dextran sulfate Disease Models, Animal DNA Epithelial cells Epithelial Cells - drug effects Epithelial Cells - metabolism Immunomodulation Inflammatory bowel diseases Interleukin 10 Interleukin 8 Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestine Juglans Juglans regia Mice Mice, Inbred C57BL NF-kappa B - drug effects NF-kappa B - metabolism NF-κB protein Nutrition Original Contribution Phenolic compounds Phosphorylation Plant Extracts - administration & dosage Plant Extracts - pharmacology Signal Transduction - drug effects Sodium Sulfates Tumor necrosis factor-α
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