Dose-rate effect on induction and repair rate of radiation-induced DNA double-strand breaks in a normal and an ataxia telangiectasia human fibroblast cell line

Using pulsed-field gel electrophoresis (PGFE) we measured DNA double-strand breaks (DSB) in a normal human fibroblast and in a cell derived from a patient suffering from ataxia telangiectasia (AT), a syndrome associated with a hypersensitivity to ionizing radiation. Initial DSB levels assessed after...

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Veröffentlicht in:	Biochimie 1995, Vol.77 (11), p.900-905
Hauptverfasser:	Foray, N., Arlett, C.F., Malaise, E.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	ataxia telangiectasia Ataxia Telangiectasia - genetics Ataxia Telangiectasia - pathology Cell Line Cell Survival DNA - radiation effects DNA double-strand breaks DNA Repair dose-rate effect Fibroblasts - cytology Fibroblasts - radiation effects Humans Radiation Dosage Temperature Time Factors
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